PHARM3test2
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| Streptomycin | Aminoglycoside
For gentamicin resistant enteroccal.
Vertigo
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| Gentamicin | Aminoglycoside
UTIs, combined with beta lactams
Hospital pneumonia
+penicillin for enterocccal endocarditis
Nephrotox/vertigo
tough >[2ug]
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| Tobramycin | Aminoglycoside
Best activity agains P. Aeruginosa
for bacteremia, osteomyelitis, peneumonia
Inhalation doasage form for P. aeruginosa in CF patients
verigo/nehprotox
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| Amikacin | Aminoglycoside
Most effective against resistant gram negative hospital acquired infections.
Less active against enterococcus
Auditory/nephrotox
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| Sulfamethoxazole | Used in combination with trimethoprim
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| Sulfasalazine | 90% broken into sulfapyridine by flora in the colon
this treats ulcerative colitis.
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| Silver sulfadiazine | Topical cream
Appears to work on cell wall
Adjunct therapy for burn infections
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| Trimethoprim | Anti-folate, inhibits dihydrofolate reductase
Treats UTIs caused by common gram negatives
Completely orally absorbed
Rash in extended treatment
hematological effects-esp alcoholics
teratogen, hyper K
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| TMP-SMX | Best for acute, uncomplicated UTIs. Also Chronic treatment.
AIDS patients experience high rate of side effects
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| Pneumocystitis jiroveci | Life threatening pneumonia in AIDS patients. Drug of choice is TMP-SMX. Second line is Pentamidine isethionate. Prednisone also used in treatment
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| Pentamidine | Used for Pneumocystitis jiroveci. Second line.
Injectable for treatment, inhalant for prophylaxis.
ADRs include hypotension, hypoglycemia (then diabetes after therapy), and bronchospasm when inhaled.
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| Vancomycin | IV. Adjust dose in renal failure.
Used for staph and serious gram+ infections
Given oral to treat C difficile diarrhea
Give with 3rd generation ceph for menigitis
Oto/nephrotox (with aminoglycoside)
RED MAN
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| Clindamycin | Treats abcesses, MRSA. Does not penetrate CNS. Prevents endocarditis in dental procedures. Pseudomembranous colitis from difficle
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| Nitrofurantoin | All gets peed out, treats chronic UTIs.
Gi upset
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| Polymyxin B | Topical for infections of the eye, skin, ear, wounds, and burns by aeruginosa.
Nephro/NEUROtox
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| Metronidazole | Enters brain and abscesses. MOA: reduced particles binds to intracellular macromolecules, bacteriocidal.
Treats anaerobic, B. Fragilis, H. pylori, and Difficle
Carcinogenic, disulfram with alcohol
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| Bacitracin | Eye and skin ointments.
Topical for open wounds with mixed microorganisms and conjunctivitis
Serious nephrotoxicity from injection
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| Quinupristin/Dalfopristin | IV treatment for life threatening, vancomycin-resistant, enterococcus faecium and staph
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| Linezolid | Vancomycin resistant faecium, hospital acquired pneumonia, MRSA
Reversible inhibitor of monoamine oxidase, tyramine rich foods are contraindicated
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| Amphotericin B | Binds to sterols in fungal membranes.
Nephrotoxic, reversible anemia.
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| Ketoconazole | Fungistatic at low concentrations, cidal at high.
Oral, 99% protein bound.
Causes endocrine abnormalities, ihibit steroid synthesis
6 month treatment
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| Miconazole | Monistat. Intravaginal candiasis.
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| Flucanazole | 25-30hr half life.
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| Itraconazole | 30hr half life. P450 interactions with cyclosporine. Low toxicity.
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| Griseofulvin | Disrupts fungal mitotic spindle. Static. used for ring worms (tineas) dermatophytoses.
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| Caspofungin | Echinocandin class. Inhibits synthesis of Dglucan component of cell wall. interacts with cyclosporine. Powder for injection to trai invasive aspergillosis and esophageal candidiasis.
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| Palivizumab | Monoclonal antibody to F protein of respiratory synctial virus.
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| Amantadine | blocks viral penetration and uncoating, buffers the ph of endosomes, and blocks the M2 viral protein channel.
Used for influenza A virus. Antiparkinsonian.
ADRs: CNS related.
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| Zanamivir | Orally inhaled, decreases realease of influenza A AND B from infected cells.
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| Oseltamivir. | Same as zanamavir, but can be taken orally.
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| Ribavirin | Purine nucleoside. Aerosol Only used for infants. inhibits viral rna polymerase. Can stop respiratory function, testicular lesions, teratogenic, not to be administered by pregnant doctors.
Used for RSV and Chronic Hep C
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| Trifluridine | activated by phosphorylation and inhibits viral dna/rna synthesis.
topical solution for herpes eye problems, keratitis...
ADR visual haze, teratogenic
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| Acyclovir | rapidly Phosphorylated in herpes infected cells, prevents their DNA polymerase. Antimetabolite with selective antiviral activity. NO ADRS
possible emergence of resistan herpes
Topical oral and IV.
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| Gancicyclovir | Inhibits CMV like acyclovir. teratogenic and carcinogenic,
granulocytopenia, thrombocytopenia.
Sever myelosuppression. Use latex gloves and safety glasses when administering.
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| Valacyclovir. | Converted to acyclovir after first pass metabolism. treats shingles and genital herpes.
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| Foscarnet | Inhibits DNA polymerase. Cytomegalovirus (CMV) in AIDs patients. Slow IV infusion
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| Interferons | Produce enzymes that inhibt the translation of messenger RNA
Produces: oligo adenylate synthetases, protein kinase, phosphodiesterases.
ADRs: Flu like, musculo skeletal, gi, nervous system, hematologic, cardiovascular, hepatic
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| Interferon alpha | Significant effect against: Cutaneous warts, Chronic hep B, and Chronic hep C when used with ribavarin
ALSO treats these cancers: Bladder tumors, AIDs related kaposi sarcoma, and hairy cell leukemia
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| YOU GONNA FAIL | Alex
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