Pharmacology for Nurses
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Peptic Ulcer Disease (PUD) occurs when ____ of the ___ wall occurs and can cause hemorrhage and perforation | erosion; gut
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| ____ and ____ are the most common sites of ulcers due to exposure to pepsin and acid. | Stomach; doudemun
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| ________ accompanies most PUD cases and eradication of the bacteria is essential in treating the disease | Helicobactor pylori (H. pylori)
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| PUD caused be an imbalance of normal and ____ factors | abnormal
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| PUD Treatment: treatment aims to alleviate ____, promote ____, prevent ____ such as hemorrhage, perforation or obstruction and prevent recurrence. | symptoms, healing, hemorrhage
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| PUD Treatment: antibiotics, antisecretory agents, mucosal pretectant, and ____ are used to treat PUD | antacids
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| PUD Treatment: nondrug therapy may include an ________ with bland foods with milk or cream or eating several small meals per day | ulcer diet
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| PUD Treatment: Reducing ____ use, _____ cessations, and stopping _____ use can decrease PUD | NSAIDS, alcohol, smoking
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| Antibacterial Drugs: used to ____ H. pylori | eradicate
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| Most common include amoxicillin, claritromycin, bismuth, metronidazole, and tetracycline | Antibacterial Drugs:
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| Antibacterial Drugs: do not use tetracycline in ____ women or ____ becuase it can ___ developing teeth | pregnant; children, stain
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| Antibacterial Drugs: avoid _____ with metronidazole and avoid in pregnancy | alcohol
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| Antibacterial Drugs: antibiotic ____ is ususally used | regimen
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| Histamine 2 Receptor Antagonists: Promote ulcer healing by ____ secretion of gastric acid | suppressing
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| Histamine 2 Receptor Antagonists: Climetidine (Tagamet): acts by blocking ______ and ____ gastric juices and acidity | H2 receptors and reduces
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| Histamine 2 Receptor Antagonists: Climetidine (Tagamet): can be given | PO, IM, IV
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| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): can cross ___ and has ____ CNS effects | BBB; minimal
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| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): used to treat PUD, ____, Zollinger-Ellsion syndrome, Aspiration _____ (rales heard) and heartburn/ acid indigestion/ sour stomach | GERD; pneumonitis
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| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): adverse effects include antandrogenic effects, ___ irritation, ____ libido, and pneumonia | CNS; decreases
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| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): interacts with ____, ____, theophylline, and lidocaine causing ____ levels of drug | warfarin; phenytoin; increase
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| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): administered antacids ___ hour around cimeidine | one
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| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): acts by _____ H2 receptors | blocking
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| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Can be administered __, __, __ | PO, IM, IV
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| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Adverse effects are ____ | uncommon
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| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): uses are same as ____ | cimetidine
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): acts on parietal cells of stomach to ____ gastric acid production up to 97% in 2 hours | stop
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): used for _________ therapy for PUD, erosive esophagitis, and GERD | Short-term
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): Treatment should be limited to ____ weeks | 4-6
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): adverse effects include headaches, ____, _____, ____ | nausea, vomiting, dizziness
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): _______ use can increase risk for gastric cancer and hip fracture | long-term
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| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): interacts with antiviral/ antifugals and _____ amount of drug absorbed | reduces
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| Sucralfate (Carafate): acts by creating a gel-like substance in the stomach to ____ an ulcer crater from stomach acid | protect
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| Sucralfate (Carafate): can be used to promote ____ of ulcers | healing
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| Sucralfate (Carafate): side effects are ____ and include constipation | rare
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| Sucralfate (Carafate): administer antacids and sucralfate at least ___ minutes apart | 30
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| Sucralfate (Carafate): may ____ absorption of phenytoin, theophylline, digioxin, warfarin, and some antibiotics | alter
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| Misoprostol (Cytotec): ____ is a prostaglandin E analog | chemical
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| Sucralfate (Carafate): used to treat ulcers related to _____ use | NSAID
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| Sucralfate (Carafate): acts as a prostagladin to suppress _______ secretions and maintaining adequate stomach blood flow | gastric acid
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| Sucralfate (Carafate): adverse effects include ____ and abdominal ____; can cause dysmenorrhea and spotting | diarrhea; pain
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| Sucralfate (Carafate): contraindicated during ____ because it can stimulate uterine contractions | pregnancy
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| Sucralfate (Carafate): teach to be on ____ ____ if using this drug | birth control
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| Sucralfate (Carafate): take with ____ and at ____ | meal; bedtime
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| Antacids: reacts with gastric acid to ____ acidity | lower
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| Antacids: used for PUD and my be ____ prior to anesthesia to prevent aspirations ____ | administered; pneumonitis
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| Antacids: adverse effects include _____, _____, and _____ loading | diarrhea, constipation, sodium
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| Antacids: aluminum and calcium compounds can cause _______ | constipation
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| Antacids: sodium-containing compounds can cause ____ retention (avoid in ____ patients) | fluid; heart
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| Antacids: aluminum-containing compounds can cause low ____ levels (monitor _____) | phosphate; levels
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| Antacids: magnesium compounds can also cause toxicity in ____ patients (avoid) | renal (kidney)
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| Antacids: aluminum compounds can also cause change in absorption of ____ and ____ | warfarin; tetracyclin
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| Antacids: teach to ___ tablets and follow with glass of water | chew
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| Antacids: shake ___ preparartions | liquid
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| Antacids: Take ___ hour before and ____ hours after meals | one; three
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| Antacids: take other meds ___ hour before or after antacids are given | one
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