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Ch. 78 Peptic Ulcer
Pharmacology for Nurses
| Question | Answer |
|---|---|
| Peptic Ulcer Disease (PUD) occurs when ____ of the ___ wall occurs and can cause hemorrhage and perforation | erosion; gut |
| ____ and ____ are the most common sites of ulcers due to exposure to pepsin and acid. | Stomach; doudemun |
| ________ accompanies most PUD cases and eradication of the bacteria is essential in treating the disease | Helicobactor pylori (H. pylori) |
| PUD caused be an imbalance of normal and ____ factors | abnormal |
| PUD Treatment: treatment aims to alleviate ____, promote ____, prevent ____ such as hemorrhage, perforation or obstruction and prevent recurrence. | symptoms, healing, hemorrhage |
| PUD Treatment: antibiotics, antisecretory agents, mucosal pretectant, and ____ are used to treat PUD | antacids |
| PUD Treatment: nondrug therapy may include an ________ with bland foods with milk or cream or eating several small meals per day | ulcer diet |
| PUD Treatment: Reducing ____ use, _____ cessations, and stopping _____ use can decrease PUD | NSAIDS, alcohol, smoking |
| Antibacterial Drugs: used to ____ H. pylori | eradicate |
| Most common include amoxicillin, claritromycin, bismuth, metronidazole, and tetracycline | Antibacterial Drugs: |
| Antibacterial Drugs: do not use tetracycline in ____ women or ____ becuase it can ___ developing teeth | pregnant; children, stain |
| Antibacterial Drugs: avoid _____ with metronidazole and avoid in pregnancy | alcohol |
| Antibacterial Drugs: antibiotic ____ is ususally used | regimen |
| Histamine 2 Receptor Antagonists: Promote ulcer healing by ____ secretion of gastric acid | suppressing |
| Histamine 2 Receptor Antagonists: Climetidine (Tagamet): acts by blocking ______ and ____ gastric juices and acidity | H2 receptors and reduces |
| Histamine 2 Receptor Antagonists: Climetidine (Tagamet): can be given | PO, IM, IV |
| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): can cross ___ and has ____ CNS effects | BBB; minimal |
| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): used to treat PUD, ____, Zollinger-Ellsion syndrome, Aspiration _____ (rales heard) and heartburn/ acid indigestion/ sour stomach | GERD; pneumonitis |
| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): adverse effects include antandrogenic effects, ___ irritation, ____ libido, and pneumonia | CNS; decreases |
| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): interacts with ____, ____, theophylline, and lidocaine causing ____ levels of drug | warfarin; phenytoin; increase |
| Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): administered antacids ___ hour around cimeidine | one |
| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): acts by _____ H2 receptors | blocking |
| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Can be administered __, __, __ | PO, IM, IV |
| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Adverse effects are ____ | uncommon |
| Histamine 2 Receptor Antagonists: Ranitidine (Zantac): uses are same as ____ | cimetidine |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): acts on parietal cells of stomach to ____ gastric acid production up to 97% in 2 hours | stop |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): used for _________ therapy for PUD, erosive esophagitis, and GERD | Short-term |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): Treatment should be limited to ____ weeks | 4-6 |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): adverse effects include headaches, ____, _____, ____ | nausea, vomiting, dizziness |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): _______ use can increase risk for gastric cancer and hip fracture | long-term |
| Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): interacts with antiviral/ antifugals and _____ amount of drug absorbed | reduces |
| Sucralfate (Carafate): acts by creating a gel-like substance in the stomach to ____ an ulcer crater from stomach acid | protect |
| Sucralfate (Carafate): can be used to promote ____ of ulcers | healing |
| Sucralfate (Carafate): side effects are ____ and include constipation | rare |
| Sucralfate (Carafate): administer antacids and sucralfate at least ___ minutes apart | 30 |
| Sucralfate (Carafate): may ____ absorption of phenytoin, theophylline, digioxin, warfarin, and some antibiotics | alter |
| Misoprostol (Cytotec): ____ is a prostaglandin E analog | chemical |
| Sucralfate (Carafate): used to treat ulcers related to _____ use | NSAID |
| Sucralfate (Carafate): acts as a prostagladin to suppress _______ secretions and maintaining adequate stomach blood flow | gastric acid |
| Sucralfate (Carafate): adverse effects include ____ and abdominal ____; can cause dysmenorrhea and spotting | diarrhea; pain |
| Sucralfate (Carafate): contraindicated during ____ because it can stimulate uterine contractions | pregnancy |
| Sucralfate (Carafate): teach to be on ____ ____ if using this drug | birth control |
| Sucralfate (Carafate): take with ____ and at ____ | meal; bedtime |
| Antacids: reacts with gastric acid to ____ acidity | lower |
| Antacids: used for PUD and my be ____ prior to anesthesia to prevent aspirations ____ | administered; pneumonitis |
| Antacids: adverse effects include _____, _____, and _____ loading | diarrhea, constipation, sodium |
| Antacids: aluminum and calcium compounds can cause _______ | constipation |
| Antacids: sodium-containing compounds can cause ____ retention (avoid in ____ patients) | fluid; heart |
| Antacids: aluminum-containing compounds can cause low ____ levels (monitor _____) | phosphate; levels |
| Antacids: magnesium compounds can also cause toxicity in ____ patients (avoid) | renal (kidney) |
| Antacids: aluminum compounds can also cause change in absorption of ____ and ____ | warfarin; tetracyclin |
| Antacids: teach to ___ tablets and follow with glass of water | chew |
| Antacids: shake ___ preparartions | liquid |
| Antacids: Take ___ hour before and ____ hours after meals | one; three |
| Antacids: take other meds ___ hour before or after antacids are given | one |
Created by:
emv2435
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