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Ch. 78 Peptic Ulcer

Pharmacology for Nurses

Peptic Ulcer Disease (PUD) occurs when ____ of the ___ wall occurs and can cause hemorrhage and perforation erosion; gut
____ and ____ are the most common sites of ulcers due to exposure to pepsin and acid. Stomach; doudemun
________ accompanies most PUD cases and eradication of the bacteria is essential in treating the disease Helicobactor pylori (H. pylori)
PUD caused be an imbalance of normal and ____ factors abnormal
PUD Treatment: treatment aims to alleviate ____, promote ____, prevent ____ such as hemorrhage, perforation or obstruction and prevent recurrence. symptoms, healing, hemorrhage
PUD Treatment: antibiotics, antisecretory agents, mucosal pretectant, and ____ are used to treat PUD antacids
PUD Treatment: nondrug therapy may include an ________ with bland foods with milk or cream or eating several small meals per day ulcer diet
PUD Treatment: Reducing ____ use, _____ cessations, and stopping _____ use can decrease PUD NSAIDS, alcohol, smoking
Antibacterial Drugs: used to ____ H. pylori eradicate
Most common include amoxicillin, claritromycin, bismuth, metronidazole, and tetracycline Antibacterial Drugs:
Antibacterial Drugs: do not use tetracycline in ____ women or ____ becuase it can ___ developing teeth pregnant; children, stain
Antibacterial Drugs: avoid _____ with metronidazole and avoid in pregnancy alcohol
Antibacterial Drugs: antibiotic ____ is ususally used regimen
Histamine 2 Receptor Antagonists: Promote ulcer healing by ____ secretion of gastric acid suppressing
Histamine 2 Receptor Antagonists: Climetidine (Tagamet): acts by blocking ______ and ____ gastric juices and acidity H2 receptors and reduces
Histamine 2 Receptor Antagonists: Climetidine (Tagamet): can be given PO, IM, IV
Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): can cross ___ and has ____ CNS effects BBB; minimal
Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): used to treat PUD, ____, Zollinger-Ellsion syndrome, Aspiration _____ (rales heard) and heartburn/ acid indigestion/ sour stomach GERD; pneumonitis
Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): adverse effects include antandrogenic effects, ___ irritation, ____ libido, and pneumonia CNS; decreases
Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): interacts with ____, ____, theophylline, and lidocaine causing ____ levels of drug warfarin; phenytoin; increase
Histamine 2 Receptor Antagonists: Cimetidine (Tagamet): administered antacids ___ hour around cimeidine one
Histamine 2 Receptor Antagonists: Ranitidine (Zantac): acts by _____ H2 receptors blocking
Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Can be administered __, __, __ PO, IM, IV
Histamine 2 Receptor Antagonists: Ranitidine (Zantac): Adverse effects are ____ uncommon
Histamine 2 Receptor Antagonists: Ranitidine (Zantac): uses are same as ____ cimetidine
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): acts on parietal cells of stomach to ____ gastric acid production up to 97% in 2 hours stop
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): used for _________ therapy for PUD, erosive esophagitis, and GERD Short-term
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): Treatment should be limited to ____ weeks 4-6
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): adverse effects include headaches, ____, _____, ____ nausea, vomiting, dizziness
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): _______ use can increase risk for gastric cancer and hip fracture long-term
Proton Pump Inhibitors (PPIs) Omeprazole (Prilosec): interacts with antiviral/ antifugals and _____ amount of drug absorbed reduces
Sucralfate (Carafate): acts by creating a gel-like substance in the stomach to ____ an ulcer crater from stomach acid protect
Sucralfate (Carafate): can be used to promote ____ of ulcers healing
Sucralfate (Carafate): side effects are ____ and include constipation rare
Sucralfate (Carafate): administer antacids and sucralfate at least ___ minutes apart 30
Sucralfate (Carafate): may ____ absorption of phenytoin, theophylline, digioxin, warfarin, and some antibiotics alter
Misoprostol (Cytotec): ____ is a prostaglandin E analog chemical
Sucralfate (Carafate): used to treat ulcers related to _____ use NSAID
Sucralfate (Carafate): acts as a prostagladin to suppress _______ secretions and maintaining adequate stomach blood flow gastric acid
Sucralfate (Carafate): adverse effects include ____ and abdominal ____; can cause dysmenorrhea and spotting diarrhea; pain
Sucralfate (Carafate): contraindicated during ____ because it can stimulate uterine contractions pregnancy
Sucralfate (Carafate): teach to be on ____ ____ if using this drug birth control
Sucralfate (Carafate): take with ____ and at ____ meal; bedtime
Antacids: reacts with gastric acid to ____ acidity lower
Antacids: used for PUD and my be ____ prior to anesthesia to prevent aspirations ____ administered; pneumonitis
Antacids: adverse effects include _____, _____, and _____ loading diarrhea, constipation, sodium
Antacids: aluminum and calcium compounds can cause _______ constipation
Antacids: sodium-containing compounds can cause ____ retention (avoid in ____ patients) fluid; heart
Antacids: aluminum-containing compounds can cause low ____ levels (monitor _____) phosphate; levels
Antacids: magnesium compounds can also cause toxicity in ____ patients (avoid) renal (kidney)
Antacids: aluminum compounds can also cause change in absorption of ____ and ____ warfarin; tetracyclin
Antacids: teach to ___ tablets and follow with glass of water chew
Antacids: shake ___ preparartions liquid
Antacids: Take ___ hour before and ____ hours after meals one; three
Antacids: take other meds ___ hour before or after antacids are given one
Created by: emv2435