Pharmacology NUR300
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| Agonists drugs? | activate receptors, mimic actions of molecules
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| Antagonists | block receptor activation
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| Cholinergic receptors | mediate response to acetycholine
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| Adrenergic receptors | mediate responses to epinephrine and norepinephrine
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| nicotinic N | ANS ganglia
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| Nicotinic M | NM junction
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| muscarinic | sweat glands, blood vessels, prostate, bladder, male sex organs
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| Alpha 1 | eye, skin arterioles, prostate, bladder, male sex organs
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| Alpha 2 | presynaptic nerve terminals
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| Beta 1 | heart, kidney
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| Beta 2 | arterioles of heart, lungs, skeletal muscles, liver, uterus
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| Dopaminergic | Kidney
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| Muscarinic Agonists | bradycardia, sweating, salivation, bronchial secretions, constriction of bronchi, constriction of the pupil (miosis), contraction of the ciliary muscle (near vision), increase tone of GI smooth muscle, diarrhea
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| Bethanecol uses? | Urinary retention not caused by blockage
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| Bethanecol side effects? | diarrhea, hypotension, decrease HR, salivation, exacerbate asthma
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| Pilocarpine uses? | glaucoma, dry mouth
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| Pilocarpine side effects? | retinal detachment, excessive sweating
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| Muscarinic antagonists | Increase HR, decrease secretion, relaxation of bronchi, constipation, pupil dilation (mydriasis)
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| Atropine uses? | bradycardia, eye surgery, severe diarrhea, pathanocol overdose
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| atropine side effects | dry mouth, blurred vision, increase IOP, urinary retention, constipation, anhidrosis, tachycardia, bronchial plugging in asthma
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| Oxybutynin (Ditropan)uses? | overactive bladder
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| Oxybutynin side effects? | puridisis, confusion
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| Cholinesterase Inhibitors | blockage of the enzyme responsible for breaking down ACh, increase nicotinic effects and muscarinic effects
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| Neostigmine uses? | myasthenia gravis, increase ACh in neuromuscular junctions, MUSCLE STIMULATION
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| Neostigmine side effects | RESPIRATORY FAILURE,
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| Edrophonium (Tensilon) uses? | diagnose MG, myasthenic crisis or cholinergic crisis
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| neuromuscular blockers | block nicotinic M receptors on skeletal muscles, relaxes skeletal muscle
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| Succinylcholine uses? | paralytic
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| Alpha 1 | mydriasis and vasoconstriction
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| Alpha 2 | CNS-reduction in sympathetic outflow to th eheart and blood vessels
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| Beta 1 | increase HR, frouce of myocardial contraction, enhance impulse conduction through the AV node
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| Beta 2 | promotes bronchodilation in asthma, relaxes smooth muscle in uterus
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| Dopamine receptor | renal perfusion
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| Epinephrine uses? | anaphylaxis, cardiac arrest, superficial bleeding, bronchodilation
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| Epinephrine side effects? | hypertension, dysrhythmias, chest pain, tissue neocrosis, increase blood glucose
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| Dopamine uses? | shock, heart failure, promotes cardiac and renal performance
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| Alpha 1 blocking | hypotension and reduced contration of bladder smoth muscle and prostate
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| Doxazosin (Cardura)/ Tamsulosin (Flomax)(-OSIN)uses? | Hypertension, BPH
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| Doxazosin (Cardura)/Tamsulosin (Flomax) (-OSIN)side effects | hypotension, impotence
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| Phenotolamine (Regitine) uses? | hypertension, prevention of tissue neocrosis
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| Phenotolamine (Regitine) side effects? | hypotension
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| Beta blockers | angina, HTN, dysrhythmias, HF, stage fright, glaucoma
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| Adverse side effects of beta1 blockers | bradycardia, reduced CO, HF, rebound cardiac excitation
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| Adverse side effects of beta2 blockers | bronchoconstriction, hypoglycemia
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| Propanolol (-OLOL, -ILOL)uses | HTN, angina, dysrhythmias
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| Propanolol side effects | bradycardia, reduced CO, HF, stage fright, glaucoma, bronchoconstriction, hypoglycemia, fatigue, impotence
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| Metoprolol (Lopressor/Toprol), Atenolol (Temormin)uses? | HTN, angina, dysrhythmias
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| Metoprolol (Lopressor/Toprol), Atenolol (Temormin) side effects? | bradycardia, HF, impotence, fatigue
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| Centrally acting alpha 2 agonists | HTN, decrease release of NE
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| Clonidine (Catapress)uses? | HTN, severe cancer pain
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| Clonidine (Catapress) side effects? | impotence, nightmares, anxiety, depression, drowsiness, rebound hypertension
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