CorticoSteriods
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| What are corticosteroids? | Hormones produced in the adrenal cortex. They're important to maintaining homeostasis. Too much or little secretions causes diseases.
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| What activates the release of the corticosteroids? | Variety of stimulus's such as Pain, anxiety, trauma, illness, anesthesia
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| What Brain area controls the release of the corticosteroid secretions? | Hypothalamus, anterior pituitary, and adrenal cortex
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| What is secreted after a traumatized event in the hypothalamus? | Corticotropin-releasing hormone or factor (CHR or CRF), which stimulates the anterior pituitary to secrete corticotropin.
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| What does corticotropin stimulate? | corticosteriods which is stimulated by the adrenal cortex
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| What is the Negative Feedback system? | Mechanism where hypothalamus and anterior pituitary learn that no more corticosteriods are needed. It doesn't work during stress.
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| Why are glucocorticoids important? | Important in metabolic, inflammatory, and immune processes. (Remember MII)The largest amt is secreted in the morning.
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| What are adverse effects of systemic corticosteriods? | Infection, hypertension, glucose intolerance, obesity, cosmetic change, bone loss, growth retardation in children, cataracts, pancreatitis, peptic ulcerations, and psychiatric disturbances
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| What happens when you take a corticosteriod for long-term use? | Major adverse effect is suppression of the HPA axis and loss of adrenocorticol function.
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| What is the HPA axis? | Hypothalamic Pituitary Adrenal (HPA) Axis suppression. It controls the body's cortisol level (stress hormone) Its responsible for controlling all the hormones.
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| What happens with the HPA axis is suppressed? | The body will not function properly such as stress and low energy levels, which can manifest in fatigue, suppressed immune system, depression, and anxiety
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| What is the function of the corticotropin-releaing hormone? | Stimulate pituitary synthesis of ACTH during a stress response
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