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CorticoSteriods 1


What are corticosteroids? Hormones produced in the adrenal cortex. They're important to maintaining homeostasis. Too much or little secretions causes diseases.
What activates the release of the corticosteroids? Variety of stimulus's such as Pain, anxiety, trauma, illness, anesthesia
What Brain area controls the release of the corticosteroid secretions? Hypothalamus, anterior pituitary, and adrenal cortex
What is secreted after a traumatized event in the hypothalamus? Corticotropin-releasing hormone or factor (CHR or CRF), which stimulates the anterior pituitary to secrete corticotropin.
What does corticotropin stimulate? corticosteriods which is stimulated by the adrenal cortex
What is the Negative Feedback system? Mechanism where hypothalamus and anterior pituitary learn that no more corticosteriods are needed. It doesn't work during stress.
Why are glucocorticoids important? Important in metabolic, inflammatory, and immune processes. (Remember MII)The largest amt is secreted in the morning.
What are adverse effects of systemic corticosteriods? Infection, hypertension, glucose intolerance, obesity, cosmetic change, bone loss, growth retardation in children, cataracts, pancreatitis, peptic ulcerations, and psychiatric disturbances
What happens when you take a corticosteriod for long-term use? Major adverse effect is suppression of the HPA axis and loss of adrenocorticol function.
What is the HPA axis? Hypothalamic Pituitary Adrenal (HPA) Axis suppression. It controls the body's cortisol level (stress hormone) Its responsible for controlling all the hormones.
What happens with the HPA axis is suppressed? The body will not function properly such as stress and low energy levels, which can manifest in fatigue, suppressed immune system, depression, and anxiety
What is the function of the corticotropin-releaing hormone? Stimulate pituitary synthesis of ACTH during a stress response
Created by: leep1022