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Thatcher Directed Study Skin 609

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Microfilaments   Actin & Myosin  
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Actin   structural microfilaments composed of F actin  
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F Actin   G actins polymerized into a double helix  
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G actin   monomeric actin subunits  
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Spectrin   actin crosslinking protein that forms networks in erthyrocytes  
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Dystrophin   actin crosslinking protein that forms networks in striated muscle  
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Myosin   a structural microfilament as well as a motor protein for actin  
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actomyosin   actin and myosin associated with each other  
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stress fibers   bundles of actomyosin anchored to the basal surface of fibroblasts which are themselves attached to substratum. produce tension across a cell layer  
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Microtubules   polymers of alpha and beta tubulin, Tau and MAPs  
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Tau and MAPs   microtubular crosslinking proteins that form networks  
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Intermediate filaments   structural component of cytoskeleton. complexes composed of proteins that have similar alpha helical cores. distinctive terminal domains  
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keratin   major intermediate filament of epithelial cells ex. hair and nails  
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nuclear lamins   intermediate filaments supporting the nuclear membrane  
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Extracellular Matrix   collagens, elastin, fibrillin, glycosaminoglycans, hyaluronans, proteoglycans, heparin, laminin, fibronectin  
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collagens   extracellular matrix fibers that resist stretching, composed of 3 helices coiled around each other in a triple helix  
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elastin   stretchable extracellular matrix fibers that provide tissues with pliability  
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fibrillin   glycoprotein microfibrils that provide a scaffold for assembly of elastic fibers  
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glycosaminoglycans   polysaccharides of the extracellular matrix composed of disaccharide repeats of modified sugars  
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hyaluronans   a particularly large glycosaminoglycan that exists free in the extracellular matrix  
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proteoglycans   extracellular matrix components, composed of core proteins attached to one or more glycosaminoglycans  
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heparin   a regulatory proteoglycan control inflammation  
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laminin   extracellular matrix crosslinking protein with multiple binding domains for different factors  
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Junctions   zona occludens, gap junctions, zonula adherens, circumferential belt, spot desmosomes, hemidesmosomes, focal adhesions, membrane-microfilament binding proteins  
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Zonula occludens   thin bands of membrane around the apical perimeters of epithelial cells, held closely together by proteins such as occludin and claudin. they seal cells to prevent diffusion of molecules across the epithelium  
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gap junctions   transmembrane complexes that allow diffusion of small molecules between cells to vesicles  
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zonula adherens   rows of structures anchoring actin microfilaments to the apical surface of epithelial cells, just beneath the tight junction  
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circumferential belt   microfilament bundles (actin and myosin) that encircle the apical perimeter of epithelial cells at the level of the belt desmosomes  
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hemidesmosomes   structures that anchor the intermediate filament cytoskeleton of an epithelial cell the basal lamina  
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focal adhesions   structures that anchor microfilament stress fibers to the basal surface of many cells, particularly epithelial cells  
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membrane-microfilament binding proteins   membrane associated proteins that anchor the microfilament cytoskeleton to the plasma membrane by binding actin crosslinking proteins  
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Crosslinking proteins   factors that bind filaments together  
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networks   filaments crosslinked into three dimensional, crisscrossed meshworks, can resist both stretching and compression  
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bundles   filaments crosslinked in parallel to form fibers that resist stretching  
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