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Cell Biology DS
Thatcher Directed Study Skin 609
| Question | Answer |
|---|---|
| Microfilaments | Actin & Myosin |
| Actin | structural microfilaments composed of F actin |
| F Actin | G actins polymerized into a double helix |
| G actin | monomeric actin subunits |
| Spectrin | actin crosslinking protein that forms networks in erthyrocytes |
| Dystrophin | actin crosslinking protein that forms networks in striated muscle |
| Myosin | a structural microfilament as well as a motor protein for actin |
| actomyosin | actin and myosin associated with each other |
| stress fibers | bundles of actomyosin anchored to the basal surface of fibroblasts which are themselves attached to substratum. produce tension across a cell layer |
| Microtubules | polymers of alpha and beta tubulin, Tau and MAPs |
| Tau and MAPs | microtubular crosslinking proteins that form networks |
| Intermediate filaments | structural component of cytoskeleton. complexes composed of proteins that have similar alpha helical cores. distinctive terminal domains |
| keratin | major intermediate filament of epithelial cells ex. hair and nails |
| nuclear lamins | intermediate filaments supporting the nuclear membrane |
| Extracellular Matrix | collagens, elastin, fibrillin, glycosaminoglycans, hyaluronans, proteoglycans, heparin, laminin, fibronectin |
| collagens | extracellular matrix fibers that resist stretching, composed of 3 helices coiled around each other in a triple helix |
| elastin | stretchable extracellular matrix fibers that provide tissues with pliability |
| fibrillin | glycoprotein microfibrils that provide a scaffold for assembly of elastic fibers |
| glycosaminoglycans | polysaccharides of the extracellular matrix composed of disaccharide repeats of modified sugars |
| hyaluronans | a particularly large glycosaminoglycan that exists free in the extracellular matrix |
| proteoglycans | extracellular matrix components, composed of core proteins attached to one or more glycosaminoglycans |
| heparin | a regulatory proteoglycan control inflammation |
| laminin | extracellular matrix crosslinking protein with multiple binding domains for different factors |
| Junctions | zona occludens, gap junctions, zonula adherens, circumferential belt, spot desmosomes, hemidesmosomes, focal adhesions, membrane-microfilament binding proteins |
| Zonula occludens | thin bands of membrane around the apical perimeters of epithelial cells, held closely together by proteins such as occludin and claudin. they seal cells to prevent diffusion of molecules across the epithelium |
| gap junctions | transmembrane complexes that allow diffusion of small molecules between cells to vesicles |
| zonula adherens | rows of structures anchoring actin microfilaments to the apical surface of epithelial cells, just beneath the tight junction |
| circumferential belt | microfilament bundles (actin and myosin) that encircle the apical perimeter of epithelial cells at the level of the belt desmosomes |
| hemidesmosomes | structures that anchor the intermediate filament cytoskeleton of an epithelial cell the basal lamina |
| focal adhesions | structures that anchor microfilament stress fibers to the basal surface of many cells, particularly epithelial cells |
| membrane-microfilament binding proteins | membrane associated proteins that anchor the microfilament cytoskeleton to the plasma membrane by binding actin crosslinking proteins |
| Crosslinking proteins | factors that bind filaments together |
| networks | filaments crosslinked into three dimensional, crisscrossed meshworks, can resist both stretching and compression |
| bundles | filaments crosslinked in parallel to form fibers that resist stretching |
Created by:
lhumm07
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