Question | Answer |
What happened to 5-HT in depression and anxiety disorders to cause them | decreased levels |
DOC family for Typical Depression | SSRI’s |
DOC family for Atypical Depression | MAOIs, but dangerous SE |
Inhibits DA, 5HT, NE storage; used as 2nd line in atypical depression and elderly depression; can cause psychosis (3) drugs? | modafinil; amphetamine; methylphenidate |
* Heterocyclic antidepressants least likely to affect sexual performance, used for management of nicotine withdrawal, SE's include dizziness, dry mouth, aggravation of psychosis, and seizures | Buropion |
*TCA used in chronic pain, enuresis, and ADD | Imipramine |
*DOC for bipolar affective disorder | Lithium |
*SE of lithium | Tremor, sedation, ataxia, aphasia, thyroid enlargement, and reversible diabetes insipidus |
* Major route of elimination for Lithium | kidney |
*Patients being treated with lithium, who are dehydrated, or taking diuretics concurrently, could develop | lithium toxicity |
***5HT-3 antagonist used in chemotherapeutic induced emesis | Ondansetron, granisetron,
dolasetron and alosetron |
** DOC of chemo induced nausea and vomiting | ondansetron |
* Ergot alkaloid used as an illicit drug | LSD |
*Disease caused by excess ergot alkaloids | St. Anthony’s Fire |
**5HT-1d agonist used for migraine headaches | Sumatriptan, naratriptan, and rizatriptan |
MAO-B inhibitor, MAO-A inhibitor at higher doses | Selegiline |
Pt has a hard time keeping with a Rx diet, which MAOI should be used? | Selegaline |
3 MAOI’s that are reversible | Moclobemide, Befloxatone, brofaromine |
Irreversible MAOI’s | Iproniazid, , Isocarboxazid phenelzine |
Problems with Rx an MAOI | liverand drug interactions; P450 inducer |
TCA used for OCD | clomipramine |
Elderly Pt’s taking TCA’s are especially susceptible to this | orthostatic hypotension |
TCA used for nocturnal enuresis | imipramine |
Drug Class: amitriptyline | TCA |
Drug Class: clomipramine | TCA |
Drug Class: Desipramine | TCA |
Drug Class: Doxepine | TCA |
Drug Class: Imipramine | TCA |
Drug Class: Nortriptyline | TCA |
Drug Class: Protriptyline | TCA |
Drug Class: Trimipramine | TCA |
Drug Class: Citalopram | SSRI |
Drug Class: Fluoxetine | SSRI |
Drug Class: Fluvoxamine | SSRI |
Drug Class: Paroxetine | SSRI |
Drug Class: Sertraline | SSRI |
SSRI associated with diarrhea | sertraline |
SSRI associated with constipation | paroxetine |
SSRI’s are used as | 1st line for depression, anxiety, and OCD |
Difference in SSRI from TCA | SSRIs are more selective for 5HT transporters and larger therapeutic index |
SNRIs inhibit what? | 5HT and NE uptake |
Venlafaxine acts as what at what doses? | SSRI at low concentration; increases 5HT and NE at high concentration |
Used to treat neuropathic pain and depression, but can cause neuroleptic malignant syndrome | duloxetine |
Used to treat depression and smoking cessation | bupropion |
Drug used to treat depression with the least sexual side effects and induces less mania | bupropion |
Used to treat elderly with depression, helping with appetite and sleep, but can cause agranulocytosis | mirtazapine |
Used to treat insomnia but causes priapism | trazadone |
2 drugs that block post-synaptic 5HT2 receptors | trazadone, nefazodone |
Non-TCA that can cause orthostatic hypotension and liver failure | nefazodone |
Treats anxiety with little sedating effects and is non-addictive. Drug and serious side effects | Buspirone; MI, CVA |
Class of drugs taken at onset of migraine aura and their side effects | triptans; coronary artery spasm, MI/CVA/seizure/hypertensive crisis |
5HT 2A/2C receptor antagonist; treats glaucoma(topically) Drug name and SE | Ketanserin; orthostatic hypotension, V-tach |
5HT 3 Receptor antagonist. Name and what it treats | Ondansetron; anti-emetic, useless in nausea |
Ondansetron’s adverse side effects | arrhythmia, bronchospasm |
2 drugs used to treat IBS with constipation and the receptor they act on | Tegaserod, Prucalopride; 5HT 4 Receptor antagonist |
Drug used to treat IBS with diarrhea and the receptor it acts on | Alosetron; 5HT 3 Receptor antagonist |
4 “mood stabalizers” | carbamazepine, Valproic Acid, Lamotrigine, Lithium |
Treatment of Bipolar affective disorder that has extensive toxicities | Lithium |