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Pharm 13 Serotonin
LECOM Pharm Ch 13 Serotonin
| Question | Answer |
|---|---|
| What happened to 5-HT in depression and anxiety disorders to cause them | decreased levels |
| DOC family for Typical Depression | SSRI’s |
| DOC family for Atypical Depression | MAOIs, but dangerous SE |
| Inhibits DA, 5HT, NE storage; used as 2nd line in atypical depression and elderly depression; can cause psychosis (3) drugs? | modafinil; amphetamine; methylphenidate |
| * Heterocyclic antidepressants least likely to affect sexual performance, used for management of nicotine withdrawal, SE's include dizziness, dry mouth, aggravation of psychosis, and seizures | Buropion |
| *TCA used in chronic pain, enuresis, and ADD | Imipramine |
| *DOC for bipolar affective disorder | Lithium |
| *SE of lithium | Tremor, sedation, ataxia, aphasia, thyroid enlargement, and reversible diabetes insipidus |
| * Major route of elimination for Lithium | kidney |
| *Patients being treated with lithium, who are dehydrated, or taking diuretics concurrently, could develop | lithium toxicity |
| ***5HT-3 antagonist used in chemotherapeutic induced emesis | Ondansetron, granisetron, dolasetron and alosetron |
| ** DOC of chemo induced nausea and vomiting | ondansetron |
| * Ergot alkaloid used as an illicit drug | LSD |
| *Disease caused by excess ergot alkaloids | St. Anthony’s Fire |
| **5HT-1d agonist used for migraine headaches | Sumatriptan, naratriptan, and rizatriptan |
| MAO-B inhibitor, MAO-A inhibitor at higher doses | Selegiline |
| Pt has a hard time keeping with a Rx diet, which MAOI should be used? | Selegaline |
| 3 MAOI’s that are reversible | Moclobemide, Befloxatone, brofaromine |
| Irreversible MAOI’s | Iproniazid, , Isocarboxazid phenelzine |
| Problems with Rx an MAOI | liverand drug interactions; P450 inducer |
| TCA used for OCD | clomipramine |
| Elderly Pt’s taking TCA’s are especially susceptible to this | orthostatic hypotension |
| TCA used for nocturnal enuresis | imipramine |
| Drug Class: amitriptyline | TCA |
| Drug Class: clomipramine | TCA |
| Drug Class: Desipramine | TCA |
| Drug Class: Doxepine | TCA |
| Drug Class: Imipramine | TCA |
| Drug Class: Nortriptyline | TCA |
| Drug Class: Protriptyline | TCA |
| Drug Class: Trimipramine | TCA |
| Drug Class: Citalopram | SSRI |
| Drug Class: Fluoxetine | SSRI |
| Drug Class: Fluvoxamine | SSRI |
| Drug Class: Paroxetine | SSRI |
| Drug Class: Sertraline | SSRI |
| SSRI associated with diarrhea | sertraline |
| SSRI associated with constipation | paroxetine |
| SSRI’s are used as | 1st line for depression, anxiety, and OCD |
| Difference in SSRI from TCA | SSRIs are more selective for 5HT transporters and larger therapeutic index |
| SNRIs inhibit what? | 5HT and NE uptake |
| Venlafaxine acts as what at what doses? | SSRI at low concentration; increases 5HT and NE at high concentration |
| Used to treat neuropathic pain and depression, but can cause neuroleptic malignant syndrome | duloxetine |
| Used to treat depression and smoking cessation | bupropion |
| Drug used to treat depression with the least sexual side effects and induces less mania | bupropion |
| Used to treat elderly with depression, helping with appetite and sleep, but can cause agranulocytosis | mirtazapine |
| Used to treat insomnia but causes priapism | trazadone |
| 2 drugs that block post-synaptic 5HT2 receptors | trazadone, nefazodone |
| Non-TCA that can cause orthostatic hypotension and liver failure | nefazodone |
| Treats anxiety with little sedating effects and is non-addictive. Drug and serious side effects | Buspirone; MI, CVA |
| Class of drugs taken at onset of migraine aura and their side effects | triptans; coronary artery spasm, MI/CVA/seizure/hypertensive crisis |
| 5HT 2A/2C receptor antagonist; treats glaucoma(topically) Drug name and SE | Ketanserin; orthostatic hypotension, V-tach |
| 5HT 3 Receptor antagonist. Name and what it treats | Ondansetron; anti-emetic, useless in nausea |
| Ondansetron’s adverse side effects | arrhythmia, bronchospasm |
| 2 drugs used to treat IBS with constipation and the receptor they act on | Tegaserod, Prucalopride; 5HT 4 Receptor antagonist |
| Drug used to treat IBS with diarrhea and the receptor it acts on | Alosetron; 5HT 3 Receptor antagonist |
| 4 “mood stabalizers” | carbamazepine, Valproic Acid, Lamotrigine, Lithium |
| Treatment of Bipolar affective disorder that has extensive toxicities | Lithium |
Created by:
csheck
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