Question | Answer |
What is the Pathophysiology of BPH | Enlargement of prostate that compresses urethra constriction and interfers with urination |
What do Alpha blocking agents do? | Promote relaxation in the prostate, and relax smooth muscle. BUT DO NOT reduce prostate size. |
Side effects of Alpha blocking agents | orthostatic hypotension, dizziness |
What do 5-a-reductase inhibitors do? | Reduce size of prostate
Blocks DHT (dihydrotestosterone) |
Side effects of 5-a-reductase inhibitors | Impotence, and decreased libido |
types of Alpha blocking agents | doxazosin (Cardura), Terazosin( Hytrin), Tamsulosin(FLomax), Alfuzosin (uroxatral) |
Clinical ManifestationsBPH: Obstructive | decreased caliber or force of stream, terminal dribbling, retention, difficulty initiating voiding |
CLinical Manifestations of BPH: Irritative | urgency, dysuria, frequency, incontinence, nocturia |
Etiology and Risk factors of BPH | Family history, environment, Diet: increased sat. fats (butter, beef), Obesity (increased waist circumference) |
Complications of BPH | Acute urinary retention, UTI, Septicemia secondary to UTI, bladder calculi, Pyelonephritis, hydronephrosis leading to renal failure. |
Surgical treatment for BPH | TURP |