Question | Answer |
GENERIC NAME | None |
BRAND NAME | Magnesium Sulfate |
CLASS | Electrolyte |
MECHANISM OF ACTION | Reduces striated muscle contractions and blocks peripheral neuromuscular transmission, manages seizures in toxemia of pregnancy, induces uterine relaxation, can cause bronchodilation after beta agonists and anticholinergics have been used. |
INDICATIONS | Seizures of eclampsia, torsade de pointes, hypomagnesemia, class IIa agent for V-fib/pulseless V-Tach that is refractory to lidocaine. |
CONTRAINDICATIONS | Heart blocks, myocardial damage. |
ADVERSE REACTIONS | CNS depression, facial flushing, diaphoresis, depressed reflexes, circulatory collapse, Hypotension. |
NOTES ON ADMINISTRATION | Pregnancy category B. Recommended that this drug not be given in the 2 hours before delivery, if possible. IV calcium chloride or calcium gluconate should be available as a magnesium antagonist if needed. Use with caution in patients with renal failure. |
INCOMPATABILITIES/DRUG INTERACTIONS | May enhance the effects of other CNS depressants, serious changes in overall cardiac function may occur with cardiac glycosides. |
DOSE/ROUTE | Adult, Seizure activity associated with pregnancy |
Adult, Cardiac arrest due to hypomagnesemia or torsade de pointes | 1-2g diluted in 10ml of D5W IV/IO over 5-20 minutes. |
Adult, Torsade de pointes with a pulse or AMI with Hypomagnesemia | Loading dose of 1-2g mixed in 50-100 ml in D5W over 5-60 minutes IVZ. |
Pediatric, IV/IO infusion | 25-50 mg/kg (max dose 2g) over 10-20 minutes. Faster for torsade de pointes. |
Pediatric, for asthma | 25-50mg/kg over 10-20 minutes. Max dose 2g |
ONSET OF ACTION | IV/IO immediate. IM 3-4 hours. |
PEAK EFFECTS | N/A |
DURATION OF ACTION | 30 minutes IV/IO, 3-4 hours IM |
AZ DRUG BOX SUPPLY RANGE | 5g. |