Question | Answer |
Definition: Triptans | Antimigraine agents |
NSAIDS: Therapeutic Action | Fever reduction, inflammation reduction, and mild-moderate pain. |
Fever is the cause of fever-inducing substances called: | Pyrogens |
_______________ help the hypothalamus regulate temperatures and tolerate a higher temperature. | Cytokines. |
List the classic signs of inflammation: | Tumor, calor, rubor, dolor, & functio laesa. (swelling, heat, redness, pain, & loss of function) |
List the cellular response of inflammation: | 1. Margination of WBCs
2. Emigration of WBCs
3. Chemotaxis
4. Phagocytosis |
Salicylates & NSAIDS: Method of Action | Inhibits COX and decreasing prostaglandins and thromboxane. |
What is the major difference between NSAIDS and salicylates? | NSAIDS actions on the body are reversible, where as the actions of salicylates is irreversible. |
Aspirin: Normal Dosage | Max: 4 grams / day
Half life: 15 min
Peak time: 2 hours
Absorption rate: 30 min |
Aspirin: Therapeutic Usage | Mild-moderate pain, especially pain resulting from inflammation. |
Aspirin: Contraindications | Peptic ulcer disease, bleeding disorders, gout, renal or liver impairment, Reye syndrome, pregnancy, lactating women, smoking, alcohol, elderly patients, and patients with respiratory function issues. |
Aspirin: Adverse Effects | Salicylism (mild aspirin toxicity) occurs with long-term usage or continuous high dosage.
Salicylate poisoning (life-threatening) Lethal dosage for children: 5-8 grams. Adults: 10-30 grams. There is no antidote.
GI issues may occur as well. |
Aspirin: Drug Interactions | anticoagulants, oral hypoglycemics, insulin, methotrexate, and alcohol may be enhanced. Ibuprofen may hinder effects. May also cause false numbers on glucose tests. |
Ibuprofen: Route and dosage, 1/2 life, & How long does this drug last in the body? | PO: 200-800mg, does not exceed 3200mg/day
Rapid onset
lasts 24 hours
1/2 life: 1.8-2.0 hours |
Ibuprofen: Therapeutic Effects | Arthritis, mild - moderate pain, primary dysmenorrhia, migraine, headache, and fever. |
Ibuprofen: Contraindications | Before or after coronary artery bypass graft procedures, cardiovascular or cerebrovascular conditions, hepatic, renal or hemopoietic disorders, or elderly. |
Ibuprofen: Precautions | Can cause GI bleeding, liver dysfunction, platelet irregularities, and stomach ulcers. |