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Pain
Chapter 24: NSAIDS
| Question | Answer |
|---|---|
| Definition: Triptans | Antimigraine agents |
| NSAIDS: Therapeutic Action | Fever reduction, inflammation reduction, and mild-moderate pain. |
| Fever is the cause of fever-inducing substances called: | Pyrogens |
| _______________ help the hypothalamus regulate temperatures and tolerate a higher temperature. | Cytokines. |
| List the classic signs of inflammation: | Tumor, calor, rubor, dolor, & functio laesa. (swelling, heat, redness, pain, & loss of function) |
| List the cellular response of inflammation: | 1. Margination of WBCs 2. Emigration of WBCs 3. Chemotaxis 4. Phagocytosis |
| Salicylates & NSAIDS: Method of Action | Inhibits COX and decreasing prostaglandins and thromboxane. |
| What is the major difference between NSAIDS and salicylates? | NSAIDS actions on the body are reversible, where as the actions of salicylates is irreversible. |
| Aspirin: Normal Dosage | Max: 4 grams / day Half life: 15 min Peak time: 2 hours Absorption rate: 30 min |
| Aspirin: Therapeutic Usage | Mild-moderate pain, especially pain resulting from inflammation. |
| Aspirin: Contraindications | Peptic ulcer disease, bleeding disorders, gout, renal or liver impairment, Reye syndrome, pregnancy, lactating women, smoking, alcohol, elderly patients, and patients with respiratory function issues. |
| Aspirin: Adverse Effects | Salicylism (mild aspirin toxicity) occurs with long-term usage or continuous high dosage. Salicylate poisoning (life-threatening) Lethal dosage for children: 5-8 grams. Adults: 10-30 grams. There is no antidote. GI issues may occur as well. |
| Aspirin: Drug Interactions | anticoagulants, oral hypoglycemics, insulin, methotrexate, and alcohol may be enhanced. Ibuprofen may hinder effects. May also cause false numbers on glucose tests. |
| Ibuprofen: Route and dosage, 1/2 life, & How long does this drug last in the body? | PO: 200-800mg, does not exceed 3200mg/day Rapid onset lasts 24 hours 1/2 life: 1.8-2.0 hours |
| Ibuprofen: Therapeutic Effects | Arthritis, mild - moderate pain, primary dysmenorrhia, migraine, headache, and fever. |
| Ibuprofen: Contraindications | Before or after coronary artery bypass graft procedures, cardiovascular or cerebrovascular conditions, hepatic, renal or hemopoietic disorders, or elderly. |
| Ibuprofen: Precautions | Can cause GI bleeding, liver dysfunction, platelet irregularities, and stomach ulcers. |
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