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Chapter 24: NSAIDS

Definition: Triptans Antimigraine agents
NSAIDS: Therapeutic Action Fever reduction, inflammation reduction, and mild-moderate pain.
Fever is the cause of fever-inducing substances called: Pyrogens
_______________ help the hypothalamus regulate temperatures and tolerate a higher temperature. Cytokines.
List the classic signs of inflammation: Tumor, calor, rubor, dolor, & functio laesa. (swelling, heat, redness, pain, & loss of function)
List the cellular response of inflammation: 1. Margination of WBCs 2. Emigration of WBCs 3. Chemotaxis 4. Phagocytosis
Salicylates & NSAIDS: Method of Action Inhibits COX and decreasing prostaglandins and thromboxane.
What is the major difference between NSAIDS and salicylates? NSAIDS actions on the body are reversible, where as the actions of salicylates is irreversible.
Aspirin: Normal Dosage Max: 4 grams / day Half life: 15 min Peak time: 2 hours Absorption rate: 30 min
Aspirin: Therapeutic Usage Mild-moderate pain, especially pain resulting from inflammation.
Aspirin: Contraindications Peptic ulcer disease, bleeding disorders, gout, renal or liver impairment, Reye syndrome, pregnancy, lactating women, smoking, alcohol, elderly patients, and patients with respiratory function issues.
Aspirin: Adverse Effects Salicylism (mild aspirin toxicity) occurs with long-term usage or continuous high dosage. Salicylate poisoning (life-threatening) Lethal dosage for children: 5-8 grams. Adults: 10-30 grams. There is no antidote. GI issues may occur as well.
Aspirin: Drug Interactions anticoagulants, oral hypoglycemics, insulin, methotrexate, and alcohol may be enhanced. Ibuprofen may hinder effects. May also cause false numbers on glucose tests.
Ibuprofen: Route and dosage, 1/2 life, & How long does this drug last in the body? PO: 200-800mg, does not exceed 3200mg/day Rapid onset lasts 24 hours 1/2 life: 1.8-2.0 hours
Ibuprofen: Therapeutic Effects Arthritis, mild - moderate pain, primary dysmenorrhia, migraine, headache, and fever.
Ibuprofen: Contraindications Before or after coronary artery bypass graft procedures, cardiovascular or cerebrovascular conditions, hepatic, renal or hemopoietic disorders, or elderly.
Ibuprofen: Precautions Can cause GI bleeding, liver dysfunction, platelet irregularities, and stomach ulcers.
Created by: happygolucky9822