Question | Answer |
Anticonvulsants | topiramate (Topamax),
divalproex (Depakote) , |
Antidepressants | fluoxetine (Prozac),
amitriptyline (Elavil) |
NSAIDs | aspirin, naproxen (Aleve),
ibuprofen (Advil, Motrin) |
Serotonin (5-HT) agonists - Adverse effects: | Category X
Peripheral vasoconstriction
GI, muscle cramps |
"Triptan” agents (5-HT agonists) | treat/stop migraine |
"Triptan” agents (5-HT agonists) adverse | Chest tightness & drowsiness |
Fluoxetine | selective serotonin reuptake inhibitor (SSRIs): antidepressants |
Fluxetine adverse effects | anxiety, insomnia, tremor, anorexia, sexual dysfunction |
amitriptyline | tricyclic antidepressant (TCA) |
anticonvulsant adverse effects: | sedation, tremor, weight gain |
amitriptyline adverse effects | drowsiness, tremor, anticholinergic effects (dry mouth blurred vision, urinary retention |
naproxen - NSAIDs | block thromboxane synthesis and platelet aggregation, reduce the release of serotonin |
Timolol - B antagonist, propanolol | propanolol widely used for migraine prophylaxis but can cause more CNS side effects than timolol |
Calcium channel blockers: | used for mygraine prophylaxis, by preventing the vasoconstrictive phase of migraine headaches |
Ergotamine and dihydroergotamine | treatment of migraine headaches and cluster headaches |
Classes for migraines prevention | anticonvulsants |
Classes for migraines prevention | antidepressants |
Classes for migraines prevention | NSAIDs |
Classes for migraines prevention | B antagonists |
Classes for migraines prevention | Calcium channel blockers |
Classes for migraines prevention | 5-HT 2 receptor antagonist |
"Triptan" for treating migrains | sumatriptan |
"Triptan" for treating migrains | rizatriptan : oral |
"Triptan" for treating migrains | zolmitriptan : oral |
"triptan" adverse effects | chest tightness |
"triptan" adverse effects | weakness |
"triptan" adverse effects | somnolence |
"triptan" adverse effects | dizziness |
"triptan" adverse effects | abnormal tingling or burning sensation (paresthesias) in the skin or various parts of the body |
"triptan" adverse effects | cause coronary vasospasm |
"triptan" contraindicated | should not be used in pt with angina pectoris, MI, or coronary artery disease, uncontrolled hypertension |
Other drugs prevent migrains | Vitamins.supplement.herbals |
Naproxen | either to prevent or to abort a migraine ATTACK |
Combination formulations of acetaminophen, butalbital, caffeine | aborting migraine headaches |
Isometheptene | terminate migrain headaches |
Tramadol | one of the most widely used opioid drugs for the treatment of migraines |
Butorphanol | nasal spray formulation for rapid onset of action |
prochlorperazine | IV, aborting UNremitting migraine headache |
Tension HA's treatment | NSAID and muscle relaxants, amitriptyline |
Tension ha | bilateral, nonpulsatile, band-like pressure |
TRiptan drugs and ergot alkaloids moa | cause vasoconstriction, used with restricted dose to avoid rebound headache and adverse effects |
ergots adverse effects | nausea, vomiting, muscle cramps |
triptan and ergots (ergotamine, dihydroergotamine) | not for coronary artery disease pt |