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Pharm test 3

chap 29

Anticonvulsants topiramate (Topamax), divalproex (Depakote) ,
Antidepressants fluoxetine (Prozac), amitriptyline (Elavil)
NSAIDs aspirin, naproxen (Aleve), ibuprofen (Advil, Motrin)
Serotonin (5-HT) agonists - Adverse effects: Category X Peripheral vasoconstriction GI, muscle cramps
"Triptan” agents (5-HT agonists) treat/stop migraine
"Triptan” agents (5-HT agonists) adverse Chest tightness & drowsiness
Fluoxetine selective serotonin reuptake inhibitor (SSRIs): antidepressants
Fluxetine adverse effects anxiety, insomnia, tremor, anorexia, sexual dysfunction
amitriptyline tricyclic antidepressant (TCA)
anticonvulsant adverse effects: sedation, tremor, weight gain
amitriptyline adverse effects drowsiness, tremor, anticholinergic effects (dry mouth blurred vision, urinary retention
naproxen - NSAIDs block thromboxane synthesis and platelet aggregation, reduce the release of serotonin
Timolol - B antagonist, propanolol propanolol widely used for migraine prophylaxis but can cause more CNS side effects than timolol
Calcium channel blockers: used for mygraine prophylaxis, by preventing the vasoconstrictive phase of migraine headaches
Ergotamine and dihydroergotamine treatment of migraine headaches and cluster headaches
Classes for migraines prevention anticonvulsants
Classes for migraines prevention antidepressants
Classes for migraines prevention NSAIDs
Classes for migraines prevention B antagonists
Classes for migraines prevention Calcium channel blockers
Classes for migraines prevention 5-HT 2 receptor antagonist
"Triptan" for treating migrains sumatriptan
"Triptan" for treating migrains rizatriptan : oral
"Triptan" for treating migrains zolmitriptan : oral
"triptan" adverse effects chest tightness
"triptan" adverse effects weakness
"triptan" adverse effects somnolence
"triptan" adverse effects dizziness
"triptan" adverse effects abnormal tingling or burning sensation (paresthesias) in the skin or various parts of the body
"triptan" adverse effects cause coronary vasospasm
"triptan" contraindicated should not be used in pt with angina pectoris, MI, or coronary artery disease, uncontrolled hypertension
Other drugs prevent migrains Vitamins.supplement.herbals
Naproxen either to prevent or to abort a migraine ATTACK
Combination formulations of acetaminophen, butalbital, caffeine aborting migraine headaches
Isometheptene terminate migrain headaches
Tramadol one of the most widely used opioid drugs for the treatment of migraines
Butorphanol nasal spray formulation for rapid onset of action
prochlorperazine IV, aborting UNremitting migraine headache
Tension HA's treatment NSAID and muscle relaxants, amitriptyline
Tension ha bilateral, nonpulsatile, band-like pressure
TRiptan drugs and ergot alkaloids moa cause vasoconstriction, used with restricted dose to avoid rebound headache and adverse effects
ergots adverse effects nausea, vomiting, muscle cramps
triptan and ergots (ergotamine, dihydroergotamine) not for coronary artery disease pt
Created by: prinluu