| Question | Answer |
| ACE mechanisms | prevents Angio I to Angio II |
| ARB mechanisms | block angio II |
| aldosterone does | sodium and water retention |
| Selective α-adrenoreceptor antagonists does? | block sympathetic stimulation which leads to vasodilatation & decreased vascular resistance |
| Reflex stimulation of SNS | increase HR, contractile force, & NE circulation |
| B Blockers do? | inhibit renin secretion. |
| Selective β1 –blockers cautions with? | asthma, COPD, diabetes |
| nonselective B blocker cautions with? | Contraindicated with asthma & COPD |
| dry mouth | clonidine (centrally acting drug) |
| sedation | clonidine (centrally acting drug) |
| Rebound hypertension | clonidine (centrally acting drug) |
| ACE does? | reduce PVR =>lower BP => for hypertension
end in "-pril" |
| cough | ACE, direct Renin inhibitor (alikiren) |
| alternation in taste | ACE |
| angioedema | ACE, direct renin inhi (aliskiren) |
| pregnacy catogaries C and D | ACE or ARB |
| renal protective, cerepro-protective | ACE |
| end in -sartan | ARB |
| hyperkalemia | ARB |
| neutropenia | ARB |
| liver enzymes | ARB |
| pregnancy categories C and D | ACE, ARB |
| GI | alikiren (direct renin inh) |
| what to monitor when administering Thiazides? | monitor potassium, glucose, uric acid, & lipids |
| what drug for hypertensive pt with CHD? | b-blocker |
| what drug for hypertensive pt with Diabetes? | BB cautiously selected |
| hypertension with asthma | dont use BB, use ACE and CCB |
| reflex tachycardia | hydralazine (vasodilator) |
| fluid retention | hydralazine (vasodilator), doxazosin, prazosin, terazosin (a-anta) |
| Orthostatic hypotension | selective B1 blockers, doxazosin, terazosin, prazosin (a-anta) |
| Hypokalemia | thiazide, loop |
| hyperuricemia (elevated uric acid) | thiazide |
| hyperlipidemia | thiazide |
| hypercalcimea | thiazide |
| cause aggravation of diabetes | thiazide |
| blood cell deficiencies | diuretics |
| tinnius | loop diuretics |
| hypertension with poor renal function | loop diuretic |
| dizziness | a-antagonists |
| first-dose syncope | a-antagonist |
| drugs with fluid retention that use in combination with diuretics | doxazosin, terazosin, prazosin (a-anta) |
| hyperkalemia | potassium-sparing (triamterene, spironolactone, eplerenone, amiloride) |
| what drug to avoid age over 65 years with hypertension? | centrally acting a2-agonist |
| what drug to avoid in African with HTN | b-blocker |
