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pharm test 1-1
mudcarinic
| Question | Answer |
|---|---|
| Muscarinic agonist action | Direct-acting, binds reversibly to muscarinic cholergenic receptors, little or no effect on nicotinic receptors |
| Bethanechol effects | Elicits all of the responses typical of muscarinic receptors activation |
| Bethanechol administration | SQ or PO. Positive charge so absorption decreased in GI (need larger dose PO). SQ absorbed well |
| Bethanechol uses | Limited, usually urinary retention where it relaxes the urinary sphinters and increases voiding pressure. Investigational use in GI disorders. |
| Bethanechol adverse effects | Rare with PO, more common in SQ. Hypotension and bradycardia (contraindicated if pregnant) |
| Bethanechol contraindicated: | Gastric ulcers, intestinal obstruction, recent bowel surgery, latent ot active asthma, hyperthytoidism (riding of dysrhythmias), caution with GU, obstruction or weakness of the bladder |
| Types of muscarinic agonists: | Bethanechol, pilocarpine, acetylcholine, muscarine |
| Muscarinic agonist drugs do what? | They bind to muscarinic receptors and cause activation. They mimic the PSNS do AKA parsdympsthomimetics |
| Muscatinic agonist toxicology | Muscarinic poisoning from certain mushrooms and OD of directing-acting muscarinic agonists or cholinesterase inhibitors. Antidote is atropine |
| What do muscarinic antagonists do? | They competitively block the actions of ACh st muscarinic receptors. AKA: parasympatholytics, antimuscarinics, muscarinic blockers, and antichlinergics |
Created by:
Keller_KI
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