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pharm test 1-1

mudcarinic

QuestionAnswer
Muscarinic agonist action Direct-acting, binds reversibly to muscarinic cholergenic receptors, little or no effect on nicotinic receptors
Bethanechol effects Elicits all of the responses typical of muscarinic receptors activation
Bethanechol administration SQ or PO. Positive charge so absorption decreased in GI (need larger dose PO). SQ absorbed well
Bethanechol uses Limited, usually urinary retention where it relaxes the urinary sphinters and increases voiding pressure. Investigational use in GI disorders.
Bethanechol adverse effects Rare with PO, more common in SQ. Hypotension and bradycardia (contraindicated if pregnant)
Bethanechol contraindicated: Gastric ulcers, intestinal obstruction, recent bowel surgery, latent ot active asthma, hyperthytoidism (riding of dysrhythmias), caution with GU, obstruction or weakness of the bladder
Types of muscarinic agonists: Bethanechol, pilocarpine, acetylcholine, muscarine
Muscarinic agonist drugs do what? They bind to muscarinic receptors and cause activation. They mimic the PSNS do AKA parsdympsthomimetics
Muscatinic agonist toxicology Muscarinic poisoning from certain mushrooms and OD of directing-acting muscarinic agonists or cholinesterase inhibitors. Antidote is atropine
What do muscarinic antagonists do? They competitively block the actions of ACh st muscarinic receptors. AKA: parasympatholytics, antimuscarinics, muscarinic blockers, and antichlinergics
Created by: Keller_KI