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MS 5 RA and Lupus

RA and Lupus

QuestionAnswer
Which glomerular dz would you suspect most in a pt with the following findings?: MC nephrotic syndrome in children minimal change dz
Which glomerular dz would you suspect most in a pt with the following findings?: MC nephrotic syndrome in adults FSGS
Which glomerular dz would you suspect most in a pt with the following findings?: Kimmelstiel-Wilson lesions (nodular glomerulosclerosis) Diabetic nephropathy
Which glomerular dz would you suspect most in a pt with the following findings?: LM: crescent formation in the glomeruli Crescenteric/RPGN
Which glomerular dz would you suspect most in a pt with the following findings?: LM: segmental sclerosis and hyalinosis FSGS
Which glomerular dz would you suspect most in a pt with the following findings?: anti-GBM Ab, hematuria, hemoptysis Goodpastures
Which glomerular dz would you suspect most in a pt with the following findings?: positive ANCA crescenteric/RPGN
Which glomerular dz would you suspect most in a pt with the following findings?: nephrotic syndrome a/w hep B membranoproliferative GN
Which glomerular dz would you suspect most in a pt with the following findings?: nephrotic syndrome a/w HIV FSGS
Positive p-ANCA is a/w what conditions? Pauci-immune GN, microscopic polyangitis, Churg-Strauss, UC, and PSC
A husband asks that his wife (your pt) not be told about her recently-discovered lung cancer. What should you do? Have an open-ended conversation about why he doesn't want you to tell her. Ultimatley, though, your responsibility is to the pt who has a right to know her dx.
How long must you have sx of RA to be dx? 6 weeks
What is the mainstay of tx for RA? NSAIDs (high dose) + steroids. Can also add DMARDs.
Name 3 major DMARDs (disease-modifying anti-rheumatic drugs) sulfasalazine, hydroxychloroquine, and MTX. Can also use anti-TNF drugs, cyclosporines, or leflunomide.
What disease should you include in your differential with arthropathy of the following joints?: DIP and PIP OA
What disease should you include in your differential with arthropathy of the following joints?: PIP and MCP (but not DIP) Rhematoid Arthritis (remember R.A.D.S.= in Rheumatoid Arthritis, Dip is Spared)
What disease should you include in your differential with arthropathy of the following joints?: isolated MCP joints (squred off bone ends and hook-like osteophytes of the MCPs) Hemochromatosis
What are the deformities of the hand a/w RA? Swan neck: DIP flexed with hyperextended PIP. Boutoniere's: PIP flexed, DIP extended. Also ulnar deviation and MCP hypertrophy
What factors tend to elicit joint pain and stiffness in RA? What factors tend to relieve pain/stiffness? How does this differ from the pattern seen in OA? RA: morning stiffness, improves with use. OA: stiffness/pain that worsens throughout day and is improved with rest.
What disease is a/w each of the following serologic markers?: anti-histone Ab drug-induced lupus
What disease is a/w each of the following serologic markers?: rheumatoid factor RA
What disease is a/w each of the following serologic markers?: anti-dsDNA Ab SLE
What disease is a/w each of the following serologic markers?: anti-Sm Ab SLE
What disease is a/w each of the following serologic markers?: HLA-DR4 RA
What disease is a/w each of the following serologic markers?: anti-mitochondrial Ab PBC
What are the 4 skin findings that are diagnostic criteria for SLE? Discoid rash, malar rash, photosens, and painless oral ulcers
What disease is a/w each of the following serologic markers?: Name 7 non-skin diagnostic criteria for SLE Non-erosive arthritis in at least 2 joints, serositis (pleuritis or pericarditis), + ANA, renal dz, neuro (seizures, psychosis), hemat d/o (anemia, leukopenia), and immune d/o (dsDNA, anti-smith, anti-phospholipid, false + VDRL)
Which drugs cause a lupus-like syndrome? SHIPP: Sulfasalazine, Hydralazine, INH, Phenytoin, and Procainamide
Created by: sarah3148