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Heme/Onc 8 (Neoplsm)

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What is the classic presentation of polycythemia vera? Average age of onset 50-60 yrs, visual distubances, thrombosis(15%), Erythromelegia(burning pain in the hands and feet with erythema, pallor, or cyanosis), pruritis, facial plethora, hepatosplenomegaly.
What lab findings are seen in polycythemia vera? elevated H&H and red cell mass, basophilia, leukocytosis (40%), thrombocytosis(60%)
What is tx for polycythemia vera? phlebotomy to keep Hct <45% in men and 42% in women, add hydroxyurea (if at high-risk for thrombosis), ASA qd prevent thrombosis, IFN-a(if refractory pruritis or erythrocytosis), allopurinol(if hyperuricemia)
A 66 y/o woman fractures her hip after falling from standing. XRAYS show "punched out" lesions in vertebrae, hips & femurs. She has increasing back pain, weakness, fatigue. Labs show anemia, hypercalcemia, & increase BUN & Cr. What tests should you do? She has MM. Get SPEP and UPEP and bone marrow biopsy(to make a definitive diagnosis).
A 21 y/o male pt. presents with recent weight loss, pruritis, and night sweats. PE reveals hepatosplenomegaly and a nontender cervical lymphadenopathy. What do you immediately suspect? Hodgkins lymphoma
Which blood cell pathology matches the following high yield description: associated with EBV (in Africa) Burkitt Lymphoma
Which blood cell pathology matches the following high yield description: reed-sternberg cell, cervial lymphadenopathy, night sweats Hodgkin lymphoma
Which blood cell pathology matches the following high yield description: bence-jones proteins, osteolytic lesions, high calcium Multiple myeloma (MM)
Which blood cell pathology matches the following high yield description: Translocatin 14;18 follicular lymphoma
Which blood cell pathology matches the following high yield description: most common lymphoma in the US diffuse large B cell
Which blood cell pathology matches the following high yield description: translocation 8;14 burkitt lymphoma
Which blood cell pathology matches the following high yield description: translocation 9;22 CML (some ALL and AML)
Which blood cell pathology matches the following high yield description: mc form of hodgkin lymphoma nodular sclerosis
Which blood cell pathology matches the following high yield description: "stary-sky pattern" due to phagocytosis of apoptotic tumor cells Burkitt lymphoma
Which blood cell pathology matches the following high yield description: high hematocrit/hgb, pruritis(esp. after hot bath or shower), burning pain in hands or feet polycythemia vera
Which blood cell pathology matches the following high yield description: white cells have hair-like projections, splenomegaly hairy cell leukemia
Which blood cell pathology matches the following high yield description: macrocytosis; hypogranular granulocytes with bilobed nuclei MDS
Name the EPO producing tumors. RCC, pheochromocytoma, HCC, Hemangioblastoma
______is the most common cancer in children. ALL
Down syndrome is associated with _______ (AML/ALL). ALL. Remember "We ALL go DOWN together"-->ALL is associated with down sydrome and Alz dz.
__________is the drug of choice for treatment of any philadelphia chromosome + tumor Imatinib
Which age group does CML and AML affect? ML="Mid Life". So 60-65 yrs
In which leukemia will you find smudge cells? CLL
In which leukemia will you find notched nuclei and Auer rods? AML
___________(Non-HL/HL) has a bimodal distribution of occuring in 20-40 yrs old or >60 years old. HL (Hodgkins lymphoma
___________(Non-HL/HL)has a poor prognosis. Non-HL
Created by: shelybel
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