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Heme Onc 4 Leuk D/O
Leukocyte Disorders and Hypersensitivity
Question | Answer |
---|---|
What drugs are known for causing elevated prolactin levels? | Antipsychotics (phenothiazine, risperidone, haliperidol), methyldopa, verapamil |
What substances are known to cause hemolysis in pts with G6PD deficiency? | Sulfonamides, anti-malarials (primoquine, INH), ASA, nitrofurantoin, dapsone, fava beans |
What would you expect with eosinophilic casts found in the urine? | AIN |
What is the next step in the mgmt of a pt with febrile neutropenia due to chemo? | Admit, culture, broad-spectrum abx (cefepime or ceftazidine) |
Which type of infection will cause an eosinophilia? | Parasitic |
Which immunoglobulin class is a/w eosinophilia? | IgE |
What is the tx for anaphylaxis? | ABCs, stop inciting agent, epinephrine IM or IV, H1/H2 blockers, bronchodilators, steroids, and IVF |
WHich type of hypersensitivity?: IgE Ab attach to mast cells causing mast cell degranulation and histamine release | Type I |
WHich type of hypersensitivity?: IgM and IgG anti-cell Ab which activate the complement cascade inducing cell death | Type II |
WHich type of hypersensitivity?: IgM and IgG immune complexes which get deposited in the tissues thereby activating the complement cascade | Type III |
WHich type of hypersensitivity?: T cell and macrophage-mediated | Type IV |
Why is type IV hypersensitivity called delayed type? | delayed type because it requires secretion of lymphokines to induce macrophages to destroy surrounding tissue |
Which type of hypersensitivity?: allergic rhinitis | 1 |
Which type of hypersensitivity?: transplant rejection | 4 |
Which type of hypersensitivity?: Arthus rxn | 3 |
Which type of hypersensitivity?: drug induced or immune hemolytic anemia | 2 |
Which type of hypersensitivity?: anaphylaxis | 1 |
Which type of hypersensitivity?: asthma | 1 |
Which type of hypersensitivity?: hemolytic disease of the newborn | 2 |
Which type of hypersensitivity?: glomerulonephritis | 3 |
Which type of hypersensitivity?: allergic contact dermatitis | 4 |
Which type of hypersensitivity?: PPD testing | 4 |
Which type of hypersensitivity?: serum sickness | 3 |
Tx for type 1 hypersensitivity? | Antihistamines, bronchodilators, steroids, and leukotriene inhibitors |
Tx for type 2 hypersensitivity? | Anti-inflammatories, immunosuppressants, plasmapheresis |
Tx for type 3 hypersensitivity? | anti-inflammatories |
Tx for type 4 hypersensitivity? | corticosteroids or immunosuppressants |
Goodpasture glomerulonephritis results from auto-Ab targeting the glomerular basement membrane. Which hypersensitivity rxn is this, and how can it be treated? | Type 2. Tx with anti-inflammatories, immunosuppressants/steroids, and plasmapheresis if necessary |
A pt presents with red marks on her ear lobes and her left wrist, and is ultimately dx with nickel allergy. What type of hypersensitivity is this? | type 4 delayed |
WHat is the most important medication in the tx of anaphylaxis? | Epinephrine |
What is the ddx for eosinophilia? | DNAAACP: Drugs, Neoplasms, Allergy/Asthma, Adrenal insufficiency (Addison's), AIN, Collagen vasc dz, Parasites |