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ODSC 7A

QuestionAnswer
Neuron Cells
Inside the cell
Voltage inside is Neg 80
Resting potential Neg 60
High conc inside K+
High conc outside Na and Cl
I. Resting Membrane Potential
Membrane is very permeable to K+, it can leak out, protein channels are open at resst
Na channels are closed in a resting state
Cytoplasmic anions can not escape due to size or charge
Membrane is not very permeable to Na+
Na/K pumps out_ 3 for every_ pumped in 3 Na+ and K+
Resting membrane potential (RMP)
Most channels closed
Unequal electrolytes distribution between ECF/ICF
Na+ does NOT effect membrane potential
K+ does strongly effect membrane potential
Negative charge is mainly due to proteins
II. Concepts
Membrane potential is the voltage across the membrane
Nernst Equation defines the equilibrium potential
Two forces the drive ions across membrane chemical, and electrical
1. Chemical driving force that depends on the con gradient across membrane
2. Electrical driving force that depends on the potential difference across the membrane. Positive attached to Neg
III. Action Potential a quick event where the membrane potential rises and falls
Theshold 19mV and the cell will depolarize
When K channels closed
Refractory Period
Absolute refractory period cannot trigger another action potential
Relative refractory period very strong stimulus is required
Steps
1. Resting State high conc of K inside and Na outside
2. Threshold Reached 19mV reached
3. Depolarization Na channels opens, Na rushes in, K rushes out
4. Repolarization Na/K pumps K back in and Na Out
5. Hyperpolarization/undershoot caused by efflux of K going back into cell
6. Refractory period cannot trigger another action potential
Created by: mcap
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