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ODSC2A
ODSC2
| Question | Answer |
|---|---|
| General Components ECM | |
| Extracellular matrix ECM | is composed of hyrdated gel like ground substance with fibers |
| 1. Ground sub | is like jelly |
| Composed of | GAG, Proteoglycnas, Glycoproteins |
| 1) Glycosaminoglycans GAG | |
| 2) Proteoglycans | |
| 3) Glycoprotiens | |
| 2. Fibrous proteins | |
| Composed of | collegen, Retiular, elastic |
| 1) Collegen | |
| 2) Reticular | |
| 3) Elastic | |
| 3. Extracellular Fluid ECF | |
| Ground sub | is like jelly |
| 1) Glycosaminogylcans GAG | polysaccharides of disaccharides |
| 2) Proteoglycans | GAGS that are bound covalently to a protein core |
| Exception: | |
| 3) Glycoproteins | Structural proteins |
| Made of | fibronectin, chondronectin, and laminin |
| i. Fibronectin(FN) | |
| ii. Laminin | |
| iii. Chondronectin/osteonectin | |
| Types and function of GAGS and proteoglycans | |
| 1) Glycosaminoglycans GAG | very long unbranched chains of disaccharide amino sugars. All are sulfated amino sugar and covalentedly linked |
| Exception is | hyaluronic acid |
| 2) Proteoglycans | macromolecules, that have a core protein and many GAGS attached |
| § Protein cores are produced | on RER |
| § GAGS attached to protein in | Golgi |
| Function of proteoglycans | storage for nutrients, stop movement of microorganims, resist compression and help joints move |
| 3) Glycoproteins | fibronectin, chondronectin, laminin |
| i. Fibronectin | polypeptides linked by disulfide bonds and involved with migration of embryonic cells |
| Produced by | fibroblasts |
| ii. Chondronectin (cartilage)/osteonectin(bone) | both help collagen to bind |
| iii. Laminin | made of 3 proteins, 1 alpha and 2 Betas, form a cross pattern and help by Sulfide bond |
| Fibrous Proteins | |
| Fibrous proteins 2 | Strength and flexibility to ECM, collagen and reticular |
| 1) Collagen Fibers | made by fibroblasts, most abundant extracellular |
| i. Structure | made of 30 genes. Contains Gly and Proline about every third position because their structures stabilize the triple helical conformation of the chain. |
| ii. Basic unit | Tropocollagen, made of 3 polypeptides |
| Disease Scurvy | Without Vit C, proline cannot attach properly to form the helix, so the helix becomes unstable, defective hydroxylation |
| Synthesis, undergoes a lot of | posttranslational modification |
| Is eventually secreted as | procollogen |
| Once procollogen is secreted | modified and becomes triple standed mol |
| 2) Reticular Fibers | highly glycosylated and forms thin fibers |
| 3) Elastic Fiber | made of |
| i. Eslastin | hydrophobic, cross linked, random coil, rich is pro gly, one gene type |
| Found in | skin lungs, large vessels |
| As we age | Elastin and Collagen break down, make wrinkles |
| ii. Fibrillin | Elastic fiber covered by shealth of microfibrils. |
| Marfan Syndrom | cause by mutation in fibrillin gene, tall skinny with spidery fingers and toes, disproportional |
| Gives support to soft organs and help attach epithelial cells | |
| Ehlers | Danlos Syndrom |
Created by:
mcap
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