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A&PII

Chapter 17, 18, 19

QuestionAnswer
___ is the only fluid in the body. Blodd
Blood is composed of: Plasma & Formed of elements: Erythrocytes, Leukocytes, Platelets.
Erythro means: Red
Leuko means: White
Hematocrit means: Blood Fraction
Hematocrit: Percent of RBCs blood volume in males 47% +/- 5%
Hematocrit: Percent of RBCs blood volume in females 42 +/- 5%
Physical characteristics of blood. Sticky, opaque fluid
Color of Oxygen rich blood. Scarlet
Color of oxygen poor blood. Dark red
pH of blood 7.35-7.45
Temperature of blood 38 °C or 100.4 °F
Blood is ___ % of body weight 8%
Average volume of males blood in Liter. 5-6L
Average volume of females blood in Liter. 4-5L
Why males blood volume tend to be larger than female? Because males are larger in their body size than female.
Functions of Blood 1) Distribution of O2 and nutrients, metabolic wastes, hormones. 2) Regulation of body temperature, normal pH, adequate fluid volume. 3) Protection against Blood loss, and infection.
Characteristics of blood plasma. Straw-colored, sticky fluid, 90% water, contains over 100 different dissolved solutes.
____ are the most abundant plasma solutes and are mostly produces by the liver. Proteins
What kind and percent of proteins have the plasma solutes? 60% albumin, 36% globulins, and 4% fibrinogen
Only ___ are complete cells. WBCs
___ have no nuclei or organelles. RBCs
___ are cell fragments. Platelets
Most ___ survive in the bloodstream for only a few days. Formed elements
Most blood cells originate in ___ and do not divide. bone marrow
What are the Erythrocytes? red blood cells
Characteristics of Erythrocytes. biconcave discs, anucleate, essentially no organelles.
Erythrocytes filled with ____ for gas transport. Hemoglobin (Hb)
Erythrocytes contain the ____ protein, ___ and other proteins. plasma membrane, spectrin
____ are the major factor contributing to blood viscosity. Erythrocytes
Structural characteristics of erythrocytes that contribute to gas transport is an example of _____. Complementarity of structure and function
_____are dedicated to respiratory gar transport. RBCs
____ binds reversible with oxygen. Hemoglobin
____ means the blood cell formation. Hematopoiesis
What is the life span of erythrocytes 100-120 days
___ engulf dying RBCs in the spleen. macrophages
When the RBCs is dying, ___ and ___ are separated. Heme and globin
___ is salvaged for reuse. iron
____ is degraded to yellow the pigment bilirubin. Heme
___ secretes bilirubin (in bile) into the intestines. Liver
Degraded yellow pigment leaves the body in feces as ____. stercobilin
____ is metabolized into amino acids. Globin
____ means blood has abnormally low Oxygen carrying capacity. Anemia
Anemia is a ___ rather than a disease. Sign
What happened to the blood oxygen levels when you have anemia. blood oxygen levels cannot support normal metabolism.
What are the symptoms of anemia? fatigue, paleness, shortness of breath and chills.
What are the characteristics of Leukocytes? Make up less than 1% of total blood volume. Can leave capillaries via diapedesis. Move through tissue spaces by ameboid motion and postive chemotaxis.
_____: WBCs count over 11,000/mm3. Leukocytosis
Two types of leukocytes. Granulocytes and Agranulocytes
What are the granulocytes and their percentage population in WBCs. Neutrophils (50-70%), Eosinophils (2-4%), Basophils (0.5-1%)
What are the Agranulocytes and their percentage population in WBCs. Lymphocytes (25-45%), Monocytes (3-8%)
Characteristics of granulocytes. Cytoplasmic granules stain specifically with Wright's stain. Larger and shorter-lived than RBCs. Lobed nuclei, and phagocytic
Characteristics of Neutrophils. Most numerous WBCs. Polymorphonuclear leukocytes (PMNs). Fine granules take up both acidic and basic dyes. Give the cytoplasm a lilac color. Granules contain hydrolytic enzymes or defensins. very phagocytic a.k.a "bacteria slayers"
Characteristics of Eosinophils. Red-staining, bilobed nuclei. Red to crimson (acidophilic) coarse. Lysosome-like granules. Digest parasitic worms that are too large to phagocytized. Modulators of the immune response.
Characteristics of Basophils. Rarest WBCs. Large, purplish-black (basophilic) granules contain histamine. Are functionally similar to mast cells.
____ is a multilobed nucleus. Neutrophil
____ a bilobed nucleus, red cytoplasmic granules. Eosinophil
____ a bilobed nucleus, purplish-black cytoplasmic granules. Basophil
Characteristics of Agranulocytes. Lack visible cytoplasmic granules. Have spherical or kidney shaped nuclei
Characteristics of lymphocytes. Large, dark-purple, circular nuclei with a thin rim of blue cytoplasm. Mostly in lymphoid tissue; few circulate in the blood. Crucial to immunity.
Two types of Lymphocytes. T cells and B cells
___ act agains virus-infected cells and tumor cells. T cells
___ give rise to plasma cells, which produce antibodies. B cells
Characteristics of Monocytes. The largest leukocytes. Abundant pale-blue cytoplasm. Dark purple-staining, U or kidney-shaped nuclei.
____ leave circulation, enter tissue, and differentiate into macrophages. Monocytes
____ activate lymphocytes to mount an immune response. Monocytes
____ large spherical nucleus. Small lymphocytes
___ kidney-shaped nucleus monocytes
____ means productiion of WBCs Leukopoiesis
WBCs stimulated by ____ from ____ and mature WBCs. chemical messenger; bone marrow.
All leukocytes originate from ____ hemocytoblasts
Leukocytes disorders. Leukopenia, leukemias, acute leukemia, and chronic leukemia.
___ abnormall low WBC count-drug induced. leukopenia
___ cancerous conditions involving WBCs. Named according to the abnormal WBC clone involved. Leukemias
___ leukemia involves myeloblasts Myelocytic
___ leukemia involved lymphocytes Lymphocytic
____ involves blast-type cells and primarily affects children. Acute leukemia
___ is more prevalent in older people. Chronic leukemia.
Disorders of hemostasis. Thromboembolytic disorders, and bleeding disorders.
____ disorders means undesirable clot formation. thromoboembolytic disorders
___ disorders means abnormalities that prevent normal clot formation. Bleeding disorders
___ clot that develops and persists in an unbroken blood vessel thrombus
___ a thrombus freely floating in the blood stream. Embolus
Thromboembolytic conditions prevented by: Aspirin, Heparin, and Warfarin
____ deficient number of circulating platelets.Due to destruction of bone marrow. Platelet count less than 50, 000/mm3 is diagnostic. thrombocytopenia
___ appear due to spontaneous, widespread hemorrhage. Petechiae
Treatment for bleeding disorders (thrombocytopenia) transfusion of concentrated platelets
____ bleeding disorder prolonged bleeding especially into joint cavities. Hemophilia
Treatment of hemophilia. plasma transfusions and injection of missing factors.
___ tranfusion are used when blood loss is substantial. whole-blood
____ are used to restore oxygen-carrying capacity. packed red cells
Transfusion of incompatible blood can be ___. fatal
Blood may contain ____ or ____ antibodies (agglutinins) that act against transfused RBCs with ABO antigens not normally present. Anti-A or Anti-B
Anti-A or Anti-B form in the blood at about ___ of age. 2 months
Hemolytic disease of the newborn. erythroblastosis fetalis
In erythroblastosis fetalis, Rh- mother becomes sensitized when exposure to Rh+ blood causes her body to sythesize ____ antibodies. Anti-Rh
Anti-Rh antibodies cross the ____ and destroy the RBCs of an ____ baby. Placenta; Rh+
The baby with eythroblastosis fetalis can be treated with ____ and ____ after birth. pre-birth transfusions and exchange transfusions.
____ serum contain anti-Rh can prevent the Rh- mother from becoming sensitized. RhoGAM
Death from shock may result from ____. low blood volume
____ is the collapse of the cardiovascular system, including vasodilation and fluid shift accompanied by inefficient cardiac output. Shock
Diagnostic blood tests. Hematocrit, blood glucose tests, microscopic examination, Differential WBC count, prothrombin time and platelet counts, SMAC-a blood chemistry profile, and complete blood count (CBC).
Blood diseases of aging. chronic leukemias, anemias, clotting disorders.
Prof. Heckmann Dog (black & white color) Beauregard "Bo" Heckmann
Wet mount procedure: place specimen on slide. Add 1 drop of water or methylene blue (for contrast). Apply coverslip at ~45 angle. Remove excess fluid. Observe specimen.
Blood smear procedure: place a drop of blood on slide 1, ~1/2 inch. from end. Hold slide 2 & 45 degree angle to slide 1 and slowly advance to end. Left slide 2 & dispose in red box.
Heart is approximately the size of the ____. Located in the ____ between second rib and fifth ___ space. On the superior surface of ____. 2/3 to the left of the ___ line. ___ to the vertebral column, ___ to the sternum. Enclosed in ____a double-walled sac Fist; mediastinum; intercostal; diaphragm; midsternal; anterior; posterior; pericardium.
Functions of superficial fibrous pericardium. protects, anchors, and prevents overfilling
Layers of the heart wall Epicardium, Myocardium, Endocardium
Four chambers of the heart. right and left atria, and right and left ventricles.
___ separated internally by a septum. two atria
____ separated by a septum two ventricles
____ is the receiving chambers Atria
Walls of atria are ridged by ___. pactinate muscles
Vessels entering right atrium. Superior vena cava, inferior vena cava, coronary sinus.
Vessels entering left atrium. Right and left pulmonary veins.
___ is the discharging chambers. ventricles
In ventricles, walls are ridged by ____. trabeculae carneae
___ muscles project into the ventricular cavities. papillary
Vessel leaving the right ventricle. pulmonary trunk
vessel living the left ventricle. Aorta
___ a closed transport system. vascular system (blood vessels)
The vascular system composed of: Capillaries, Venules, Arterioles, Veins, Arteries
Function of vascular system. responsible for supplying blood tissues with blood containing oxygen and nutrients.
The heart is two side by side pumps: Right side is the pump for the ____: vessels that carry blood to and from the lungs. Left side is the pump for the _____: vessels that carry the blood to and from all body tissues. pulmonary circuit; systemic circuit
____ thoracic pain caused by a fleeting deficiency in blood delivery to the myocardium. Cells are weakened. Angina pectoris.
____ prolonged coronary blockage. Areas of cell death are repaired with non contractile scar tissue. Myocardial infarction - MCI (heart attack)
____ ensure unidirectional blood flow through the heart. Heart valves
____prevent backflow into the atria when ventricles contract. Atrioventricular valves
atrioventricular valves: ____ (right), _____ (left). Tricuspid valve; Mitral valve
____ anchor AV valve cusps to papillary muscles a.k.a heart strings. Chordae tendineae
Microscopic anatomy of cardiac muscle. ____: junctions between cells anchor cardiac cells. intercalated discs
Two types of cardiac muscle junctions. desmosomes and gap junctions
In cardiac muscle, ____ prevent cells from separating during contraction. desmosomes
In cardiac muscle, ____ allow ions to pass, electrically couple adjacent cells. gap junctions
____ of the heart is rhythmic and spontaneous. depolarization
About 1% of cardiac cells have ____ (are self-excitable) automaticity
____ensure the heart contracts as a unit. gap junctions
____ a network of noncontractile (autorhythmic) cells that initiate and distribute impulses to coordinate the depolarization and contraction of the heart. Intrinsic cardiac conduction system
In autorhythmic cells, have unstable resting potentials (pacemaker potential or prepotentials) due to open slow ___ channels. Sodium (Na+)
In autorhythmic cells, At ___ Calicium (Ca2+) channels open. threshold
Explosive ____influx produces the rising phase of the action potential in autorythmic cells. Calcium (Ca2+) influx
____ results from inactivation of Calcium channels and opening of voltage-gated K+ channels. Repolarization
This slow depolarization is due to both opening of Na+ channels and closing K+ channels. The membrane potential is not a flat line. Pacemaker potential
The action potential begins when the pacemaker potential reaches threshold. It is due to Calcium influx through Calcium channels. Depolarization
Repolarization is due to ____channels inactivating and ___ channels opening which allows efflux and brings the membrane potential back to its most negative voltage. Calcium channels; Potassium channels.
Sequence of excitation: ____ node (pacemaker) generates impulses about 75 times/minutes (sinus rhythm). Depolarizes faster than any other part of the myocardium. Sinoatrial (SA) node.
Sequence of excitation: ____ node, smaller diameter fibers; fewer gap junctions. Delays impulses aproximately 0.1 second. Depolarizes 50 times per minute in absence of SA node input. Atrioventricular (AV) node
Sequence of excitation:____ (bundle of his) Only electrical connection between the atria and ventricles. Atrioventricular (AV) bundle
Sequence of excitation:____ two pathways in the interventricular septum that carry the impulses toward the apex of the heart. Right and left bundle branches
Sequence of excitation: ____ complete the pathway into the apex and ventricular walls. Purkinje fibers
AV bundle and Purkinje fibers depolarize only ____ per minute in absence of AV node input. 30 times
Defects in the intrinsic conduction system may result in ___,___, ____. Arrhythmias, Uncoordinated atrial and ventricular contractions, and Fibrillation
____ irregular hear rhythms Arrhythmias
____ rapid, irregular contractions; useless for pumping blood fibrillation
___ is modified by the ANS Heartbeat
Cardiac centers are located in the ____ medulla oblongata
____ a composite of all the action potentials generated by nodal and contractile cells at a given time. Electrocardiogram (ECG or EKG)
Three waves of ECG. ___ wave: depolarization of SA node. ___ complex: ventricular depolarization. ___ wave ventricular repolarization. P wave; QRS complex; T wave.
Heart sounds: two sounds ____ associated with closing of heart valves lub dup
Heart sounds: first sound occurs as AV valves close and signifies ____. beginning of systole
Heart sounds: Second sound occurs when SL valves close at the ____. Beginning of ventricular diastole
____ abnormal (abnl) heart sounds most often indicative of valve problems. Heart murmurs
____: all events associated with blood flow through the heart during one complete heartbeat. cardiac cycle
In cardiac cycle, systole means heart ____. contraction
In cardiac cycle, diastole means heart ___. relaxation
____ volume of blood pumped by each ventricle in one minute. Cardiac output (CO)
CO = _____ x _____ Heart rate (HR) x Stroke volume (SV)
HR = _____. number of beats per minute
SV = ____. volume of blood pumped out by a ventricle with each beat.
EDV means End diastolic volume
ESV means end systolic volume
SV means stroke volume
Three main factors affect SV pre-load, contractility, and after-load
Factors that influence heart rate Age, Gender, Exercise, Body temperature
____: abnormally fast heart rate (>100bpm). If persistent may lead to fibrillation. Tachycardia
____: heart rate slower than 60 bpm. may result in grossly inadequate blood circulation. May be desirable result of endurance training. Bradycardia
CHF means congestive heart failure
____ is a progressive condition where the CO is so low that blood circulation is inadequate to meet tissue needs. congestive heart failure (CHF)
CHF caused by: coronary atherosclerosis, persistent high blood pressure, multiple myocardial infarcts, dilated cardiomyopathy (DCM)
Fetal heart structures that bypass pulmonary circulation. Foramen ovale (fo) and Ductus arteriosus
In fetal heart, ___ connects the two atria. foramen ovale
In fetal heart, ___ connects the pulmonary trunk and the aorta. ductus arteriosus
____ defects can lead to mixing of systemic and pulmonary blood, or involve narrowed valves or vessels that increase the workload on the heart. congenital heart
Age-related changes affecting the heart. sclerosis and thickening of valve flaps. decline in cardiac reserve. fibrosis of cardiac muscle. atherosclerosis
Cardiovascular (CV) diseases. Tachycardia, Bradycardia, pericarditis, myocarditis, endocarditis, vascular diagnosis (Dx's)
Cardiovascular disorders. Angina pectoris, Myocardial infarction (MCI or MI), Congestive heart failure (CHF), Cardiac arrest, shock
Donkey name Fiona
____ delivery system of dynamic structures that begins and ends at the heart. Blood vessels
____ carry blood away from the heart; oxygenated except for ____circulation and ____ vessels of a fetus. Arteries; pulmonary; umbilical
____ contact tissue cells and directly serve cellular needs. capillaries
____ carry blood toward the heart. Veins
Structure of blood vessel walls: Arteries and Veins contains: Tunica intima, tunica media, and tunica externa
Structure of blood vessel walls:___ central blood containing space Lumen
Structure of blood vessel walls: ____ endothilium with sparse basal lamina. capillaries
Characteristics and functions of Elastic (conducting) arteries. large thich-walled arteries with elastin in all three tunics. Aorta and its major branches. Large lumen offers low-resistance. Act as pressure reservoirs-expand and recoil as blood is ejected from the heart.
Characteristics of muscular distributing arteries and arterioles. Distal to elastic arteries; deliver blood to body organs. Have thick tunica media with more smooth muscle. Active in vasocontraction
Characteristics of arterioles. Smallest arteries. Lead to capillary beds.
Arterioles control flow into capillary beds via _____ and ____. vasodilation; vasoconstriction.
Characteristics of capillaries Microscopic blood vessels. Walls of thin tunica intima, one cell thick. Pericytes help stabilize their walls and control permeability. Size allows only a single RBC to pass at a time.
Location of capillaries. In all tissues except for cartilage, epithelia, cornea and lens of eye.
Functions of capillaries. exchange of gases, nutrients, wastes, hormones, etc.
Three structural types of capillaries. continuous capillaries, fenestrated capillaries, sinusoidal capillaries (sinusoids)
Interwoven networks of capillaries from the microcirculation between arterioles and venules. Capillary beds
Capillary beds consist of two types of vessels. Vascular shunt (metarteriole-thoroughfare channel), True capillaries
___ Formed when capillary beds unite. Very porous; allow fluids and WBCs into tissues. Venules
___ venules have one or two layers of smooth muscle cells. Larger venules
___ formed when venules converge. Have thinner walls, larger lumens compared with corresponding arteries. Blood pressure is lower than in arteries. Veins
Thin tunica media and thin tunica externa of veins consisting of ____ fibers and ____ networks. Collagen; Elastic
Veins is called _____ vessels (blood reservoirs) and contain up to ____% of blood supply. capacitance; 65%
Adaptations that ensure return of blood to the heart. Large-diameter lumens offer little resistance. Valves prevent backflow of blood.
Flattened veins with extremely thin walls (e.g. coronary sinus of the heart and dural sinuses of the brain.) Venous sinuses
Interconnections of blood vessels vascular anastomoses
____anastomoses provide alternate pathways (collateral channels) to a given body region - DETOURS Arterial
____anastomoses are common. Venous
Volume of blood flowing through a vessel, an organ, or the entire circulation in a given period. Blood flow
Blood flow measured as ___. mL/min
Blood flow is equivalent to _____ for entire vascular system. cardiac output (CO)
Blood flow is ____ when at rest. relatively constant
Blood flow circulation varies widely through individual ____ based on needs. organs
Force per unit area exerted on the wall of a blood vessel by the blood. Blood pressure (BP)
Unit of blood pressure mmHg
BP measured as ____ BP in large arteries near the heart. systemic arterial
The pressure gradient provides the driving force that keeps blood moving from ____ to ___ pressure areas. Higher to lower
Opposition to flow. measure of the amount of friction of blood encounters. Generally encountered in the peripheral systemic circulation. Resistance (peripheral resistance)
Three important source of resistance Blood viscosity, total blood vessel length, blood vessel diameter
Resistance: factors that remains relatively constant: Blood viscosity, Blood vessel length
___ alter peripheral resistance. frequent changes
Resistance varies inversely with the ____ power of vessel radius. fourth
____ arterioles are the major deterrminants of peripheral resistance. small-diameter
___ chanes in diameter of fatty plaques from atherosclerosis dramatically increase resistance. abrupt changes
Areterial blood pressure near the heart is ____. pulsatile
___ pressure exerted during ventricular contraction systolic pressure
lowest level of arterial pressure. diastolic pressure
____ = difference between systolic and diastolic pressure. pulse pressure
MAP means Mean arterial pressure
pressure that propels the blood to the tissues MAP (means arterial pressure)
MAP = diastolic pressure + 1/3 pulse pressure
capillary blood pressure ranges from ___. 15-35 mmHg
___ capillary pressure is desirable. low
___ pressure changes little during the cardiac cycle. venous blood pressure
venous blood pressure gradient is about ___. 15 mmHg
Low venous blood pressure due to cumulative effects of ____. peripheral resistance
Maintaining blood pressure requires cooperation of the: heart, blood vessels, and kidneys and supervision by the brain.
The main factor influencing blood pressure: cardiac output (CO), peripheral resistance (PR), blood volume.
pulse and blood pressure, along with respiratory rate and body temperature vital signs
pressure wave caused by the expansion and recoil of arteries pulse
(taken at the wrist) routinely used radial pulse
BP peaks in the morning due to ___. levels of hormones
blood pressure cycles over a ___ period. 24-hr
___, ____, ____, ____, ___, ____, may vary BP Age, sex, weight, race, mood, posture
____ low blood pressure: systolic pressure below 100mmHg. Often associated with long life and lack of cardiovascular illness. hypotension
Three types of hypotension orthostatic hypotension, chronic hypotension, acute hypotension
____ high blood pressure. sustained elevation arterial pressure of 140/90 mmHg or higher. Hypertension
Three types of hypertension Prolonged hypertension, primary hypertension, secondary hypertension
____ hypotension: temporary low BP and dizziness when suddenly rising from a sitting or reclining position orthostatic
___ hypotension: hint of poor nutrition and warming sign for Addison's disease or hypothyroidism chronic
___ hypotensiion: important sight of circulatory shock acute
____ is a major cause of heart failure, vascular disease, renal failure and stroke. prolonged hypertension
90% of hypertensive conditions. Due to several risk factors including heredity. diet, obesity, age, stress, diabetes, mellitus, and smoking. primary or essential hypertension
___ is less common. Due to identifiable disorders, including kidney disease, arteriosclerosis, and endocrine disorders such as hyperthyroidism and Cushing's syndrome secondary hypertension
The automatic adjustment of blood flow to each tissue in proportion to the tissue's requirements at any instant. autoregulation
Two types of autoregulation metabolic, myogenic
Temperature regulation: Heat radiates from the ___. skin
As temperature ____, hypothalamic signals reduce vasomotor stimulation of the skin vessels. temperature rises
____ also causes vasodilation via bradykinin in perspiration sweat
___stimulates the release of NO Bradykinin
As temperature ____, blood is shunted to deeper, more vital organs decreases
Any condition in which blood vessel are inadequately filled. Blood cannot circulate normally. circulatory shock
circulatory shock results in inadequate blood flow to meet ___ needs tissue
___ shock results from large-scale blood loss Hypovolemic shock
____ sock results from extreme vasodilation and decreased peripheral resistance. vascular shock
___ shock results when an inefficient heart cannot sustain adequate ciculation cardiogenic shock
Two main circulations pulmonary circulation, systemic circulation
___ circulation: short loop that run from the heart to the lungs and back to the heart pulmonary circulation
____ circulation: long loop to all parts of the body and back to the heart. systemic
The heart pumps blood by the ____ of development 4th week
Fetal shunts (foramen ovale and ductus arteriosus) bypass _____. nonfunctional lungs
A weakening and resulting local dilation of the artery wall. aneurysms
An inflammation of a vein occurs most often in the lower legs, but any vein, including cranial veins can be affected. Phlebitis
What is a mythelene blue use for? contrast
Equipment used for blood smear: Microscope slide, glass stirring rod, Wright's stain, Wash bottle, Lancets, Cotton balls, Alcohol swabs
Equipment used for dissection: Blunt probe, Needle probe, Scissors, Forceps, dissection pins, scalpels.
Use to clean the microscope Kim wipes, hand sanitizer
Equipment used for BP Sphygmomanometer, stethoscope, EKG
Created by: lhen
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