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Pharm exam
mchs, A.G.
Question | Answer |
---|---|
Bethanechol (Urecholine) Mechanism of Action | |
4 Bethanechol Adverse Effects | Hypotension due to vasodilation and bradycardia Bethanechol Uses |
Bethanechol Mechanism of Action | Activates muscarinic receptors |
Class of medication = muscarinic antagonist MUSCARINIC POISONING MUSCARINIC POISONING: Manifestation of Muscarinic Poisoning | Stimulation of muscarinic receptors causes profuse salivation |
MUSCARINIC ANTAGONISTS: Atropine Adverse Effects | Uses |
Mechanism of Action | Blocks muscarinic receptors |
Adverse Effects | Blurry vision, |
BUDCAT | B- blurry vision, photophobia, and increased intraocular pressure U- urinary retention D- dry mouth (xerostomia), decreased secretions C- constipation A- anhidrosis (absence of sweat) T- tachycardia |
ANTICHOLINERGIC DRUGS FOR OVERACTIVE BLADDER (OAB) | Oxybutynin (Ditropan, Ditropan XL, Oxytrol) |
Oxybutynin (Ditropan, Ditropan XL, Oxytrol) Uses | Overactive bladder (urge incontinence) |
Oxybutynin (Ditropan, Ditropan XL, Oxytrol) :Mechanism of Action | Blocks muscarinic (M3) receptors in the bladder |
Oxybutynin (Ditropan, Ditropan XL, Oxytrol)Adverse Effects | Blurry vision |
CHOLINESTERASE INHIBITORS | Neostigmine (Prostigmin) Neostigmine (Prostigmin) Uses |
Neostigmine (Prostigmin) Mechanism of Action | Prevents degradation of acetylcholine (ACh) |
Neostigmine (Prostigmin) Adverse Effects | Excessive glandular secretions, increased GI motility |
NEUROMUSCULAR BLOCKERS | Prototype: Succinylcholine (Anectine, Quelicin |
Succinylcholine (Anectine, Quelicin )Uses | Muscle relaxation during endotracheal intubation |
Succinylcholine (Anectine, Quelicin Mechanism of Action | Causes paralysis of muscle by preventing repolarization (fasciculations) |
Succinylcholine (Anectine, Quelicin Adverse Effects | Prolonged paralysis in genetically determined individuals |
ADRENERGIC AGONISTS | Prototype: Epinephrine |
Epinephrine Uses | Cardiac arrest, heart failure, anaphylactic shock |
Epinephrine Mechanism of Action | Activates all four adrenergic receptors (alpha1, alpha2, beta1, and beta2) |
Epinephrine Adverse Effects | HTN crisis |
Phenylephrine Uses | treatment of nasal congestion |
Mechanism of Action | Actives alpha1 receptors |
ALPHA-ADRENERGIC ANTAGONISTS | Prototype: Prazosin (Minipress) |
Adverse Effects | HTN |
Prazosin (Minipress Uses | Essential hypertension |
Prazosin (Minipress Mechanism of Action | Blocks alpha1 Receptor |
Prazosin (Minipress Adverse Effects | Orthostatic hypotension, reflex tachycardia |
BETA-ADRENERGIC ANTAGONISTS First-Generation Nonselective Beta Blockers | Prototype: Propranolol (Inderal, InnoPran) |
Propranolol (Inderal, InnoPran Uses | Hypertension, angina pectoris, cardiac dysrhythmias Propranolol (Inderal, InnoPran Mechanism of Action |
Metoprolo (Lopressor, Toprol XL) Uses | HTN |
Metoprolo (Lopressor, Toprol XL) Mechanism of Action | blocks cardiac beta 1 receptors |
Metoprolo (Lopressor, Toprol XL) Adverse Effects | Bradycardia |
Clonidine (catapres) Class of medication | Alpha2 Agonists |
Clonidine (catapres) Uses | HTN |
Clonidine (catapres) Mechanism of Action | Activates alpha2 receptors in the CNS |
Clonidine (catapres) Adverse Effects | Drowsiness and sedation |
Levodopa/Carbidopa (Sinemet) Uses | reduce symptoms of Parkinson’s disease |
Levodopa/Carbidopa (Sinemet Mechanism of Action | Levodopa increases synthesis of dopamine in the triatum |
Levodopa/Carbidopa (Sinemet Adverse Effects | several months to develop |
Levodopa/Carbidopa Class of medication = | |
Donepezil(Aricept) : Mechanism of Action | Prevents the breakdown of acetylcholine (ACh) |
Donepezil(Aricept: Uses | Alzheimer’s disease |
Donepezil(Aricept: Adverse Effects | Cholinergic effects |
Donepezil(Aricept) Class of medication | CHOLINESTRASE INHIBITORS |
Phenytoin (Dilantin): Mechanism of Action | Inhibits entry of sodium into neurons |
Phenytoin (Dilantin): Uses | Epilepsy |
Phenytoin (Dilantin): Adverse Effects | Nystagmus, nvoluntary eye movement |
Phenytoin (Dilantin) Class of medication | ANTIEPILEPTIC DRUGS (AEDs) ANTIEPILEPTIC DRUGS (AEDs) |
: Valproic Acid (Depakote): Mechanism of Action | Blocks sodium channels to suppress neurons |
: Valproic Acid (Depakote): Uses | Epilepsy, bipolar disorder, migraine headaches |
Valproic Acid (Depakote): Adverse Effects | Nausea, vomiting, |
: Valproic Acid Class of medication | ANTIEPILEPTIC DRUGS (AEDs) |
Metaxalone (Skelaxin): Mechanism of Action | Unclear; sedative properties may cause relaxation |
Metaxalone (Skelaxin): Uses | Relief of spasm resulting from muscle injury |
Metaxalone (Skelaxin): Adverse Effects | CNS depression |
Metaxalone (Skelaxin) Class of medication | MUSCLE RELAXANTS |
: Pentazocine (Talwin): Uses | Relief of mild to moderate pain |
: Pentazocine (Talwin): Adverse Effects | Physical dependence |
: Pentazocine (Talwin) Class of medication | |
: Naloxone (Narcan): Mechanism of Action | |
Reverses the effects of opioids : Naloxone (Narcan): Uses | Reversal of opioid overdose |
: Naloxone (Narcan) Adverse Effects | Minimal |
: Naloxone (Narcan) Class of medication | OPIOID ANTAGONISTS |
Ergotamine (Ergomar): Mechanism of Action | Alters transmission at serotonergic, dopaminergic |
Ergotamine (Ergomar): USE | Migraine and cluster headaches |
Ergotamine (Ergomar): A/E | N/V |
Ergotamine (Ergomar) Class of medication | ERGOT ALKALOIDS |
Sumatriptan (Imitrex): Mechanism of Action | Binds to 5-HT1B/1D (serotonin) receptors to cause vasoconstriction |
Sumatriptan (Imitrex): USE | Migraine headache |
Sumatriptan (Imitrex): A/E | Chest symptoms (heavy arms and chest pressure) |
Sumatriptan (Imitrex) Class of medication | SEROTONIN1B/1D–RECEPTOR AGONISTS (TRIPTANS) |
Chlorpromazine (Thorazine) Mechanism of Action | Extrapyramidal symptoms (EPS) (acute dystonia, parkinsonism, akathisia, tardive d : Chlorpromazine (Thorazine): USE |