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Daniel's drugs

tacrolimus tox pleural effusion,hyperglycemia, HTN, peripheral neuropathy, nephrotoxicity
cyclosporine nephrotoxic (prevent with mannitol diuresis), gout, predispose to viral infection and lymphoma
muromanab CD3 (OKT3) cytokine release syndrome,HSR
sirolimus hyperlipidemia, decreased platelets, leukopenia
azathioprine Bone marrow suppresion, 6MP met by XO
signs of sulfa allergy fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria, pruritic rash
sulfa drugs Probenecid, Furosemide, acetazolamide, celecoxib, thiazides, sulfonamide antibiotics, sulfasalazine, sulfonylureas
vanco tox nephrotox, ototox, thrombophlebitis, flushing
chloroquine retinopathy, G6PD hemolysis
topiramate kidney stones, mental dulling, weight loss, sedation
ketamine hallucination, bad dreams, disorientation, increases cerebral blood flow
ampho B fever/chills, hypotension, nephro, arrhythmia, anemia, IV phlebitis; reduce with hydration and liposomal amphotericin
cimetidine tox crosses BBB, confusion, dizziness, HA, crosses placenta
azoles inhibit hormone synthesis-> gynecomastia, liver dysfunction via decreased p450, fever/chills
leuprolide antiandrogen, N/V
sildenafil HA, flushing, dypepsia, impaired blue/green color vision, hypotension, esp in those taking nitrates
levothyroxine increased thyroid symptoms
SE of propylthiouracil hepatotoxicity
se of methimazole teratogen?
GLP 1 analog - exenatide pancreatitis
pramlintide hypogluc, N, diarrhea
hyperglycemia niacin, tacrolimus, protease inhibitors, thiazides
fat redistribution protease inhibitors, corticosteroids
gingival hyperplasia phenytoin, verapamil
which H2 blockers decrease renal excretion of creatinine? cimetidine, ranitidine
aluminum hydroxide constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures, hypokalemia
adenosin flushing, chest pain
alpha glucosidase inhibitors - acarbose, miglitol GI issues
bile acid resins GI, malabsorption, cholesterol gallstones
statins rhabdomyolysis, hepatotoxicity
digoxin cholinergic, yellow vision, increased PR, decreased QT, T inversion, arryhtmias, N/V, diarrhea, hyperkalemia
nitroprusside cyanide tox (releases cyanide)
diazoxide hyperglyemia (reduce insulin release)
il2 aldesleukin
glitazones/TZD weight gain, edema
alpha 2 blocker sedation, increased serum cholesterol, increased appetite
halothane hepatotoxictiy
methoxyflurane nephrotoxicity
enflurane seizures
nitrous oxide trapped gas expansionm
all anesthetics can cause? except NO malignant hyperthermia
latonoprost darkens color of iris (browning)
ethosuximide GI distress, fatigue, HA, urticaria, hives, SJS
carbamazepine diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of P450, SiADH, SJS
brimonidine alpha 2 agonist for glaucoma
cholinomimetics for glaucoma SE miosis, cyclospasm
disulfiram like reaction metronidazole, certain cephalosporins, first gen sulfonylureas, procarbazine
nephrotoxocity aminoglycosides, cisplatin, vancomycin, loop diuretics
P450 inducers quinidine, barbiturates, st. john's wart, phenytoin, rifampin, griseofulvin, carbamazepine, chronic ETOH
P450 inhibitors macrolides, amiodarone, grapefruit juice, cimetidine, ritonavir, acute etoh, ciprofloxacin, ketoconazole, sulfonamides
misoprostol abortifacient, diarrhea
octreotide steatorrhea, nausea, cramps
infliximab reactivate latent TB, infection, hypotension
sulfasalazine reversible oligospermia, sulfonamide
odansetron HA, constipation
propylthiouracil agranulocytosis, anemia, skin rash, hepatotoxicity
glucocorticoid tox cushing's, buffallo hump, moon facies, osteoporosis, adrenocortical atrophy, truncal obesity, muscle wasting, easy buising, peptic ulcers, diabetes (chronic), adrenal insufficiency when stopped after chronic use
rifampin orange body fluids
fluoroquinolone tox adults: tenodinitis, tendon rupture; kids -> leg gramps, myalgias; don't take with antacids, preg- damage to cartilage, GI upset, superinfections, skin rash, HA, dizziness
metronidazole disulfiram like reaction, HA, metallic taste
INH tox hepatotoxicity
how do you prevent red man syndrome? pretreatment with antihistamine, slow infusion rate
produces mydriasis and cycloplegia homotropine, tropicamide, atropine
cause seizures buproprion, imipenem/cilastitin, INH
gabapentin sedation, ataxia
lamotrigine SJS
donepezil, galantamine, rivastigmine nausea, dizziness, insomnia
parkinson like syndrome antipsychotics, reserpine, metoclopromide
seizures INH, imipenem/cilastin, buproprion
nucleosides NRTI lactic acidosis
non-nucleosides - NNRTI rash
ZDV megaloblastic anemia
NRTI bone marrow suppresion
rimantidine Does not cross BBB
ribaviron hemolytic anemia, severe teratogen
antimuscarinics atropine, TCA, H1 blocker, neuroleptics, digoxin
ketoconazole gynecomastia, amenorrhea
HRT increased CV risk, increased endometrial cancer
mifeprostone heavy bleeding, GI effects, abdominal pain
sumatriptan coronary vasospasm, mild tingling
tramadol decreases seizure threshold`
carbamazepine aplastic anemia, diplopia, sedation, ataxia, agranulocytosis, liver, teratogen, incduce P450, SIADH, SJS
pyrazinamide hyperuricemia, hepatic
ethambutol optic neuropathy -> red green color blindness
cutaneous flushing VANC - vancomycin, adenosine, niacin, CCB
agranulocytosis clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone
aplastic anemia cholramephenicol, benzene, nsaids, propylthiouracil, methimazole
hemolysis in G6PD inh, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin, dapseone
megaloblastic anemia phenytoin, methotrexate, sulfa drugs
TCA sedation, alpha blocker, anticholinergic
desipramine less sedating and lower seizure threshold
TCA tox convulsions, coma, cardiotocitiy; resp depression, hyperpyrexia, anticholinergic in elderly
barb w/d delirium, cardio collapse
depressant w/d anxiety, tremor, seizures, insomnia
stimulant withdrawal cras, depression, lethargy, weight gain, HA
mirtazepine increased appeptite, weight gain, dry mouth, sedation
SSRI tox GI distress, sexual (anorgasmia), serotonin syndrome (myoclonis, hyperthermia, cardio collapse, fushing, diarrhea, seizures)
tx for serotonin syndrome cyproheptadine
SNRI increased BP, stimulant effect, sedation, nausea
typical antipsychotic tox increased lipid soluble -> slow body removal, galactorrhea, neuroleptic malignant syndrome
maprotiline orthostatic hypotension, sedation
hydrochlorothiazide hyponatremia, hypokalemia, hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia, metabolic acidosis, sulfa
spironolacton K+ sparing; hyperkalemia, arrythmia, gynecomastia, antiandrogen effects
volume contraction leads to? alkalosis
hot flashes tamoxifen, clomiphene
flucytosine bone marrow suppresion, N/V, diarrhea
caspofungin GI upset, flushing
tetracycline tox teeth, decreased bone growth children, photosensitivity, GI distress, C/I pregnancy
chloramphenicol aplastic anemia, anemia, gray baby
terbinafine abnormal LFT, visual disturbances
triamterene, amiloride hyper K
INH hepatitis, seizures, lupus
SIADH cyclophosphamide, carbamazepine
amantadine ataxia, dizziness, slurred speech
salmeterol tremor, arryhtmia
butorphanol artial agonist; withdrawal if on full agonist
nitroglycerin, isosorbide dinitritrate flushing, HA< monday disease (loss of tolerance over weekend -> SE on MOnday)
danazol use (for endometriosis, hereditary angioedema
danazol se weight gain, edema, acne, hirsutism, masculinization, decreased HDL, pseudotumor cerebri, benign hepatic adenomas, menstrual irregularities
insulin HSR, hypoglycemia
verapamil, diltiazem flushing, edema
sotalol torsades, beta blockade
bretylium new arrythmia, decreased HTN
niacin flushing, hyperglycemia, hyperuricemia
first gen H1 blockers sedation, antimuscarinic, antialpha adrenergic
raltegravir hypercholestorlemia
interferons neutropenia
calcium carbonate hypercalcemia, rebound acid increase, can chelate and decrease effect of other drugs (tetracycline)
class 1 C antiarryhytmic proarrythmic, NO post MI, increase refractory period in AV node
AV nodal response to beta blockers increased PR interval
class 2 beta blockers impotence, increased asthma, CV depression, CNS effects, mask hypoglycemia
metoprolol dyslipidemia
furosemide ototoxicity, hypokalemia, deydration, allergy (sulfa), nephritis (interstitial), gout
busulfan pulm fibrosis, hyperpigmentation
etoposide, teniposide myelosuppresion, GI, alopecia
cylcophosphamide, ifosfamide hemorrhagic cystitis, BMS
6TG BM, liver, can be given with allopurinol
cytarabine leukopenia, decreased platelets, megaloblastic anemia
vincristine, vinblastine neuro: arreflexia, peripheral neuritis, paralytic ileus
vinblastine BmS
aspirin acute tox resp alkalosis, ulcer, tinnitus
chronic aspirin tox acute renal failure, interstitial nephritis, upper GI bleed
how does acetaminophen cause tox? depletes glutathione; causes hepatic necrosis
succinylcholine hypercalcemia, hyperkalemia
methicillin interstitial nephritis
penicillin HSR, hemolytic anemia
imipenem seizures, skin rash, GI distress
opioid withdrawal flu like, cold turkey, dilated pupils
ampicillin, amoxicillin HSR, pseudo colitis, ampicillin rash
guaifensin does not suppress cough reflex
how does adenosine affect bronchial tone bronchoconstricts
buproprion seizure esp in bulimia, stimulant effects, no sexual effects
trazadone priapism, sedation, nausea, postural hypotension
memantin dizziness, confusion, hallucination
memantin moa NMDA rec antagonist; prevents excitotoxicity (mediated by Ca)
memantin use alzheimers
foscarnet nephrotoxicity
cidofovir nephrotoxicity -> coadminister with probenecid
protease inhibitor tox lipodystrophy, hyperglycemia, GI intolerance, ritonavir inhibits P45-
amantadine MOA blocks viral penetration/uncoating (M2 protein); increase release of DA from terminals
methotrexate myelosuppression, macrovesicular fatty liver, mucositis, teratogen
cinchonism HA, tinnitus
class 1A antiarrythmic tox thrombocytopenia, torasdes (increased QT)
class 1 effects increased AP duration, ERP, and QT
disopyramide class 1a
pracainamide class1a
quinidine class1a
diabetes insipidus lithium, demecocycline
interstitial nephritis methicillin, NSAIDS, furosemide
clomiphene tox hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances
trastuzamab herceptin; cardiotoxic
hydroxyurea bmS, GI
cisplatin, carboplatin nephrotoxicity (prevent with amifostine- free radical scavenger, CL- diuresis), acoustic nerve damage
paclitaxol bmS, hypersensitivity
metoclopramide parkinson like effects, interacts with digoxin and diabetic agents, C/i in small bowel obstruction or parkinson's
magnesium hydroxide diarrhea, hyporeflexia, hypotension, cardiac arrest
epi for glaucoma mydriasis, stinging, C/I in closed angle
ergot D agonists bromocriptine
non-ergot D agonists for parkinsons's pramipexole, ropinirole
propofol less nausea than thiopental, potentiates GABA
olanzapine weight gain
clozapine agranulocytosis, seizures, weight gain
ziprasidone long QT
gout furosemide, thiazides, niacin, pyrazinamide, cyclosporine
fibrates myositis, hepatotox, cholesterol gallstones
nesiritide hypotension
nesiritide MOA recombinant BNP -> increased cGMP -> vasodilation
nesiritide use acute decompensated HF
ezetimibe rare increase in LFT
demeclocycline nephrogenic DI, bone and teeth abnormalities, photosensitivity
probenecid inhibits reabsorption of uric acid in PCT, also inhibits secretion of penicillin
NSAIDS renal damage, fluid retention, aplastic anemia, GI issues, ulcers
celecoxib increases thrombosis risk, sulfa
celecoxib use selectively blocks COX2, RA or OA use in patients with gastritis or ulcers
ticlopidine neutropenia
ticlopidine moa irreversible ADP receptor blockade
ticlopidine use ACS, stenting, decreased thrombotic stroke
cilostazol SE nausea, HA, flushing, hypotension, abdominal pain
dactinomycin myelosuppression
nitrosureas CNS -> dizziness, ataxia, can cross BBB
pilocarpine resistant to AChE
which ACHEinh crosses Bbb physostigmine
ACHE used to treat glaucoma physostigmine, echothiopahate
does not penetrate CNS pyridostigmine, neostigmine
hypothyroidism lithium, amiodarone, sulfonamides
gancyclovir tox leukopenia, neutropenia, decreased platelets, renal toxicity (more toxic than acyclovir)
mannitol pulmonary edema, dehydration; C/I anuria, CHF
acetazolamide hyperchloremic metabolic acidosis, neuropathy, NH3 tox, sulfa allergy, hypokalemia
ACE inhibitor toxicity cough, angioedema, proteinuria, taste changes, hypotension, pregnancy, renin increases, rash, lower AT2, hyperkalemia
griseofulvin tox teratogen, carcinogen, confusion, HA, increased P450 and warfarin metabolism
focal to massive hepatic necrosis halothane, acetaminophen, valproic acid, aminita phalloides
acute cholestatic hepatitis macrolides
mutagenesis metronidazole
teratogenic AB ribavirin, griseofulvan
embryotoxic clarithromycine
bisphosphanates corosive esophagitis (except zoledronate), jaw osteonecrosis, nausea, diarrhea
hydralazine lupus like syndrome, reflex tachycardia (c/i in angina/CAD)
what not to give for gout? salicylates
cephalosporins vit K def, hypersenstivity, increased nephrotoxicity of aminoglycosides
macrolides increased QT, GI, acute cholestatic hepatitis, eosinophilia, skin rashes, increased serum theophyllines, oral anticoag
inhaled anesthetics - halothane, enflurane increased cerebral blood flow (decreased cerebral metabolic demand), respiratory depression, myocardial deprsesion, N/V
increases cerebral blood flow inhaled anesthetics (halothane, enflurane), ketamine
decreased cerebral blood flow barbiturates
bleomycin pulm fibrosis, skin changes
Created by: ilovemusic007