Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Daniel's drugs
| Question | Answer |
|---|---|
| tacrolimus tox | pleural effusion,hyperglycemia, HTN, peripheral neuropathy, nephrotoxicity |
| cyclosporine | nephrotoxic (prevent with mannitol diuresis), gout, predispose to viral infection and lymphoma |
| muromanab CD3 (OKT3) | cytokine release syndrome,HSR |
| sirolimus | hyperlipidemia, decreased platelets, leukopenia |
| azathioprine | Bone marrow suppresion, 6MP met by XO |
| signs of sulfa allergy | fever, UTI, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, urticaria, pruritic rash |
| sulfa drugs | Probenecid, Furosemide, acetazolamide, celecoxib, thiazides, sulfonamide antibiotics, sulfasalazine, sulfonylureas |
| vanco tox | nephrotox, ototox, thrombophlebitis, flushing |
| chloroquine | retinopathy, G6PD hemolysis |
| topiramate | kidney stones, mental dulling, weight loss, sedation |
| ketamine | hallucination, bad dreams, disorientation, increases cerebral blood flow |
| ampho B | fever/chills, hypotension, nephro, arrhythmia, anemia, IV phlebitis; reduce with hydration and liposomal amphotericin |
| cimetidine tox | crosses BBB, confusion, dizziness, HA, crosses placenta |
| azoles | inhibit hormone synthesis-> gynecomastia, liver dysfunction via decreased p450, fever/chills |
| leuprolide | antiandrogen, N/V |
| sildenafil | HA, flushing, dypepsia, impaired blue/green color vision, hypotension, esp in those taking nitrates |
| levothyroxine | increased thyroid symptoms |
| SE of propylthiouracil | hepatotoxicity |
| se of methimazole | teratogen? |
| GLP 1 analog - exenatide | pancreatitis |
| pramlintide | hypogluc, N, diarrhea |
| hyperglycemia | niacin, tacrolimus, protease inhibitors, thiazides |
| fat redistribution | protease inhibitors, corticosteroids |
| gingival hyperplasia | phenytoin, verapamil |
| which H2 blockers decrease renal excretion of creatinine? | cimetidine, ranitidine |
| aluminum hydroxide | constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures, hypokalemia |
| adenosin | flushing, chest pain |
| alpha glucosidase inhibitors - acarbose, miglitol | GI issues |
| bile acid resins | GI, malabsorption, cholesterol gallstones |
| statins | rhabdomyolysis, hepatotoxicity |
| digoxin | cholinergic, yellow vision, increased PR, decreased QT, T inversion, arryhtmias, N/V, diarrhea, hyperkalemia |
| nitroprusside | cyanide tox (releases cyanide) |
| diazoxide | hyperglyemia (reduce insulin release) |
| il2 | aldesleukin |
| glitazones/TZD | weight gain, edema |
| alpha 2 blocker | sedation, increased serum cholesterol, increased appetite |
| halothane | hepatotoxictiy |
| methoxyflurane | nephrotoxicity |
| enflurane | seizures |
| nitrous oxide | trapped gas expansionm |
| all anesthetics can cause? except NO | malignant hyperthermia |
| latonoprost | darkens color of iris (browning) |
| ethosuximide | GI distress, fatigue, HA, urticaria, hives, SJS |
| carbamazepine | diplopia, ataxia, blood dyscrasias, liver tox, teratogenesis, induction of P450, SiADH, SJS |
| brimonidine | alpha 2 agonist for glaucoma |
| cholinomimetics for glaucoma SE | miosis, cyclospasm |
| disulfiram like reaction | metronidazole, certain cephalosporins, first gen sulfonylureas, procarbazine |
| nephrotoxocity | aminoglycosides, cisplatin, vancomycin, loop diuretics |
| P450 inducers | quinidine, barbiturates, st. john's wart, phenytoin, rifampin, griseofulvin, carbamazepine, chronic ETOH |
| P450 inhibitors | macrolides, amiodarone, grapefruit juice, cimetidine, ritonavir, acute etoh, ciprofloxacin, ketoconazole, sulfonamides |
| misoprostol | abortifacient, diarrhea |
| octreotide | steatorrhea, nausea, cramps |
| infliximab | reactivate latent TB, infection, hypotension |
| sulfasalazine | reversible oligospermia, sulfonamide |
| odansetron | HA, constipation |
| propylthiouracil | agranulocytosis, anemia, skin rash, hepatotoxicity |
| glucocorticoid tox | cushing's, buffallo hump, moon facies, osteoporosis, adrenocortical atrophy, truncal obesity, muscle wasting, easy buising, peptic ulcers, diabetes (chronic), adrenal insufficiency when stopped after chronic use |
| rifampin | orange body fluids |
| fluoroquinolone tox | adults: tenodinitis, tendon rupture; kids -> leg gramps, myalgias; don't take with antacids, preg- damage to cartilage, GI upset, superinfections, skin rash, HA, dizziness |
| metronidazole | disulfiram like reaction, HA, metallic taste |
| INH tox | hepatotoxicity |
| how do you prevent red man syndrome? | pretreatment with antihistamine, slow infusion rate |
| produces mydriasis and cycloplegia | homotropine, tropicamide, atropine |
| cause seizures | buproprion, imipenem/cilastitin, INH |
| gabapentin | sedation, ataxia |
| lamotrigine | SJS |
| donepezil, galantamine, rivastigmine | nausea, dizziness, insomnia |
| parkinson like syndrome | antipsychotics, reserpine, metoclopromide |
| seizures | INH, imipenem/cilastin, buproprion |
| nucleosides NRTI | lactic acidosis |
| non-nucleosides - NNRTI | rash |
| ZDV | megaloblastic anemia |
| NRTI | bone marrow suppresion |
| rimantidine | Does not cross BBB |
| ribaviron | hemolytic anemia, severe teratogen |
| antimuscarinics | atropine, TCA, H1 blocker, neuroleptics, digoxin |
| ketoconazole | gynecomastia, amenorrhea |
| HRT | increased CV risk, increased endometrial cancer |
| mifeprostone | heavy bleeding, GI effects, abdominal pain |
| sumatriptan | coronary vasospasm, mild tingling |
| tramadol | decreases seizure threshold` |
| carbamazepine | aplastic anemia, diplopia, sedation, ataxia, agranulocytosis, liver, teratogen, incduce P450, SIADH, SJS |
| pyrazinamide | hyperuricemia, hepatic |
| ethambutol | optic neuropathy -> red green color blindness |
| cutaneous flushing | VANC - vancomycin, adenosine, niacin, CCB |
| agranulocytosis | clozapine, carbamazepine, colchicine, propylthiouracil, methimazole, dapsone |
| aplastic anemia | cholramephenicol, benzene, nsaids, propylthiouracil, methimazole |
| hemolysis in G6PD | inh, sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin, dapseone |
| megaloblastic anemia | phenytoin, methotrexate, sulfa drugs |
| TCA | sedation, alpha blocker, anticholinergic |
| desipramine | less sedating and lower seizure threshold |
| TCA tox | convulsions, coma, cardiotocitiy; resp depression, hyperpyrexia, anticholinergic in elderly |
| TCA tx | NaHCO3 |
| barb w/d | delirium, cardio collapse |
| depressant w/d | anxiety, tremor, seizures, insomnia |
| stimulant withdrawal | cras, depression, lethargy, weight gain, HA |
| mirtazepine | increased appeptite, weight gain, dry mouth, sedation |
| SSRI tox | GI distress, sexual (anorgasmia), serotonin syndrome (myoclonis, hyperthermia, cardio collapse, fushing, diarrhea, seizures) |
| tx for serotonin syndrome | cyproheptadine |
| SNRI | increased BP, stimulant effect, sedation, nausea |
| typical antipsychotic tox | increased lipid soluble -> slow body removal, galactorrhea, neuroleptic malignant syndrome |
| maprotiline | orthostatic hypotension, sedation |
| hydrochlorothiazide | hyponatremia, hypokalemia, hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia, metabolic acidosis, sulfa |
| spironolacton | K+ sparing; hyperkalemia, arrythmia, gynecomastia, antiandrogen effects |
| volume contraction leads to? | alkalosis |
| hot flashes | tamoxifen, clomiphene |
| flucytosine | bone marrow suppresion, N/V, diarrhea |
| caspofungin | GI upset, flushing |
| tetracycline tox | teeth, decreased bone growth children, photosensitivity, GI distress, C/I pregnancy |
| chloramphenicol | aplastic anemia, anemia, gray baby |
| terbinafine | abnormal LFT, visual disturbances |
| triamterene, amiloride | hyper K |
| INH | hepatitis, seizures, lupus |
| SIADH | cyclophosphamide, carbamazepine |
| amantadine | ataxia, dizziness, slurred speech |
| salmeterol | tremor, arryhtmia |
| butorphanol | artial agonist; withdrawal if on full agonist |
| nitroglycerin, isosorbide dinitritrate | flushing, HA< monday disease (loss of tolerance over weekend -> SE on MOnday) |
| danazol use | (for endometriosis, hereditary angioedema |
| danazol se | weight gain, edema, acne, hirsutism, masculinization, decreased HDL, pseudotumor cerebri, benign hepatic adenomas, menstrual irregularities |
| insulin | HSR, hypoglycemia |
| verapamil, diltiazem | flushing, edema |
| sotalol | torsades, beta blockade |
| bretylium | new arrythmia, decreased HTN |
| niacin | flushing, hyperglycemia, hyperuricemia |
| first gen H1 blockers | sedation, antimuscarinic, antialpha adrenergic |
| raltegravir | hypercholestorlemia |
| interferons | neutropenia |
| calcium carbonate | hypercalcemia, rebound acid increase, can chelate and decrease effect of other drugs (tetracycline) |
| class 1 C antiarryhytmic | proarrythmic, NO post MI, increase refractory period in AV node |
| AV nodal response to beta blockers | increased PR interval |
| class 2 beta blockers | impotence, increased asthma, CV depression, CNS effects, mask hypoglycemia |
| metoprolol | dyslipidemia |
| furosemide | ototoxicity, hypokalemia, deydration, allergy (sulfa), nephritis (interstitial), gout |
| busulfan | pulm fibrosis, hyperpigmentation |
| etoposide, teniposide | myelosuppresion, GI, alopecia |
| cylcophosphamide, ifosfamide | hemorrhagic cystitis, BMS |
| 6TG | BM, liver, can be given with allopurinol |
| cytarabine | leukopenia, decreased platelets, megaloblastic anemia |
| vincristine, vinblastine | neuro: arreflexia, peripheral neuritis, paralytic ileus |
| vinblastine | BmS |
| aspirin acute tox | resp alkalosis, ulcer, tinnitus |
| chronic aspirin tox | acute renal failure, interstitial nephritis, upper GI bleed |
| how does acetaminophen cause tox? | depletes glutathione; causes hepatic necrosis |
| succinylcholine | hypercalcemia, hyperkalemia |
| methicillin | interstitial nephritis |
| penicillin | HSR, hemolytic anemia |
| imipenem | seizures, skin rash, GI distress |
| opioid withdrawal | flu like, cold turkey, dilated pupils |
| ampicillin, amoxicillin | HSR, pseudo colitis, ampicillin rash |
| guaifensin | does not suppress cough reflex |
| how does adenosine affect bronchial tone | bronchoconstricts |
| buproprion | seizure esp in bulimia, stimulant effects, no sexual effects |
| trazadone | priapism, sedation, nausea, postural hypotension |
| memantin | dizziness, confusion, hallucination |
| memantin moa | NMDA rec antagonist; prevents excitotoxicity (mediated by Ca) |
| memantin use | alzheimers |
| foscarnet | nephrotoxicity |
| cidofovir | nephrotoxicity -> coadminister with probenecid |
| protease inhibitor tox | lipodystrophy, hyperglycemia, GI intolerance, ritonavir inhibits P45- |
| amantadine MOA | blocks viral penetration/uncoating (M2 protein); increase release of DA from terminals |
| methotrexate | myelosuppression, macrovesicular fatty liver, mucositis, teratogen |
| cinchonism | HA, tinnitus |
| class 1A antiarrythmic tox | thrombocytopenia, torasdes (increased QT) |
| class 1 effects | increased AP duration, ERP, and QT |
| disopyramide | class 1a |
| pracainamide | class1a |
| quinidine | class1a |
| diabetes insipidus | lithium, demecocycline |
| interstitial nephritis | methicillin, NSAIDS, furosemide |
| clomiphene tox | hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances |
| trastuzamab | herceptin; cardiotoxic |
| hydroxyurea | bmS, GI |
| cisplatin, carboplatin | nephrotoxicity (prevent with amifostine- free radical scavenger, CL- diuresis), acoustic nerve damage |
| paclitaxol | bmS, hypersensitivity |
| metoclopramide | parkinson like effects, interacts with digoxin and diabetic agents, C/i in small bowel obstruction or parkinson's |
| magnesium hydroxide | diarrhea, hyporeflexia, hypotension, cardiac arrest |
| epi for glaucoma | mydriasis, stinging, C/I in closed angle |
| ergot D agonists | bromocriptine |
| non-ergot D agonists for parkinsons's | pramipexole, ropinirole |
| propofol | less nausea than thiopental, potentiates GABA |
| olanzapine | weight gain |
| clozapine | agranulocytosis, seizures, weight gain |
| ziprasidone | long QT |
| gout | furosemide, thiazides, niacin, pyrazinamide, cyclosporine |
| fibrates | myositis, hepatotox, cholesterol gallstones |
| nesiritide | hypotension |
| nesiritide MOA | recombinant BNP -> increased cGMP -> vasodilation |
| nesiritide use | acute decompensated HF |
| ezetimibe | rare increase in LFT |
| demeclocycline | nephrogenic DI, bone and teeth abnormalities, photosensitivity |
| probenecid | inhibits reabsorption of uric acid in PCT, also inhibits secretion of penicillin |
| NSAIDS | renal damage, fluid retention, aplastic anemia, GI issues, ulcers |
| celecoxib | increases thrombosis risk, sulfa |
| celecoxib use | selectively blocks COX2, RA or OA use in patients with gastritis or ulcers |
| ticlopidine | neutropenia |
| ticlopidine moa | irreversible ADP receptor blockade |
| ticlopidine use | ACS, stenting, decreased thrombotic stroke |
| cilostazol SE | nausea, HA, flushing, hypotension, abdominal pain |
| dactinomycin | myelosuppression |
| nitrosureas | CNS -> dizziness, ataxia, can cross BBB |
| pilocarpine | resistant to AChE |
| which ACHEinh crosses Bbb | physostigmine |
| ACHE used to treat glaucoma | physostigmine, echothiopahate |
| does not penetrate CNS | pyridostigmine, neostigmine |
| hypothyroidism | lithium, amiodarone, sulfonamides |
| gancyclovir tox | leukopenia, neutropenia, decreased platelets, renal toxicity (more toxic than acyclovir) |
| mannitol | pulmonary edema, dehydration; C/I anuria, CHF |
| acetazolamide | hyperchloremic metabolic acidosis, neuropathy, NH3 tox, sulfa allergy, hypokalemia |
| ACE inhibitor toxicity | cough, angioedema, proteinuria, taste changes, hypotension, pregnancy, renin increases, rash, lower AT2, hyperkalemia |
| griseofulvin tox | teratogen, carcinogen, confusion, HA, increased P450 and warfarin metabolism |
| focal to massive hepatic necrosis | halothane, acetaminophen, valproic acid, aminita phalloides |
| acute cholestatic hepatitis | macrolides |
| mutagenesis | metronidazole |
| teratogenic AB | ribavirin, griseofulvan |
| embryotoxic | clarithromycine |
| bisphosphanates | corosive esophagitis (except zoledronate), jaw osteonecrosis, nausea, diarrhea |
| hydralazine | lupus like syndrome, reflex tachycardia (c/i in angina/CAD) |
| what not to give for gout? | salicylates |
| cephalosporins | vit K def, hypersenstivity, increased nephrotoxicity of aminoglycosides |
| macrolides | increased QT, GI, acute cholestatic hepatitis, eosinophilia, skin rashes, increased serum theophyllines, oral anticoag |
| inhaled anesthetics - halothane, enflurane | increased cerebral blood flow (decreased cerebral metabolic demand), respiratory depression, myocardial deprsesion, N/V |
| increases cerebral blood flow | inhaled anesthetics (halothane, enflurane), ketamine |
| decreased cerebral blood flow | barbiturates |
| bleomycin | pulm fibrosis, skin changes |
Created by:
ilovemusic007
Popular USMLE sets