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Step 1: Immuno

Bradykinin Component of the kinin system, causes vasodiation, increases vascular permeability, stimulates smooth muscle contraction, mediates pain
Interferon-gamma Recruits leukocytes and activates phagocytosis; produced by activated T cells
C3a Component of the complement system, inflammatory anaphylotoxin that triggers histamine release from mast cells causing vasodilation and enhanced vascular permeability --- also recruits and activates neutrophils, monocytes, eosinophils and basophils
Thromboxane A2 Synthesized by platelets, causes platelet aggregation and vasoconstriction
Leukotriene B4 Stimulates neutrophil migration to sites of inflammation (others: 5-HETE, C5a)
Cytokines secreted by macrophages IL-1, IL-6, IL-8, IL-12, TNF-alpha
IL-1 An endogenous pyrogen. Causes FEVER, acute inflammation. Activates endothelium to express adhesion molecules; induces cytokine secretion to recruit leukocytes
IL-6 An endogenous pyrogen. Also is secreted by Th cells. Causes fever and stimulates production of acute phase reactant proteins.
IL-8 Major chemotactic factor for neutrophils.
IL-12 Induces differentiation of T cells into Th1 cells. Activates NK cells. Also secreted by B cells.
TNF-alpha Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak
IL-3 Secreted by T cells, supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF.
IL-2 Stimulates growth of helper and cytotoxic T cells.
Interferon-gamma Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and antitumor properties
IL-4 Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
IL-5 Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils.
IL-10 Secreted by regulatory T cells. Activates Th2.
Created by: 092309



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