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Last minute Endo
| Question | Answer |
|---|---|
| pseudohypoparathyroidism | renal unresponsiveness to PTH; AD; hypocalcemia, shortened 4-5th digit, short stature |
| mutation in Gs-a protein of adenyl cyclase | cause of pseudohypoparathyroidism |
| primary hypoparathyroidism causes | surgical removal, digeorge, autoimmune |
| PTH and Ca levels in primary hypoparathyroidism | decreased PTH -> decreased Ca |
| trousseau sign | carpal contraction provoked by inflating blood pressure cuff above systolic blood pressure for more than 3 minutes |
| where is PTH synthesized? | chief cells of the parathyroid gland |
| hypocalcemia signs | prolonged QT, muscle cramping, paresthesia, convulsions |
| insulin receptor | heterodimer of alpha and beta subunits. beta subunit is a tyrosine kinase. When insulin binds, subunit autophosphorylates itself -> activation of downstream signaling cascades. |
| rapid acting insulin | lispro, aspart, regular |
| use of insulin | life threatening HYPERkalemia, stress indduced hyperglycemia, type 1 and 2 DM, gestastional diabetes |
| MOA of sulfonylureas | close K+ channel in beta cell -> depolarization -> trigger insulin release via increased Ca influx |
| toxicity of glitazones | weight gain, edema, hepatotoxicity, CV toxicity |
| mechanism of glitazone | increase insulin sensitivity in peripheral tissue; binds to PPAR gama nuclear transcription regulator |
| acarbose, miglitol | inhibit intestinal brush border alpha glucosidases |
| pramlintide | decreases glucagon |
| exenatide | increase insulin, decrease glucagon release; GLP1 analog |
| exenatide toxicity | pancreatitis; N/V |
| LATERAL neck mass in a patient with webbed neck | neck mass is a cystic hygroma |
| thyroid is derived from endoderm at the foramen cecum, junction between the developing anterior and posterior tongue | tyhroid gland development |
| most common site of ectopic thyroid tissue | lingual thyroid - in tongue |
| diffusely enlarged painless goiter | Graves disease |
| multinodular goiter | Plummer disease |
| enlarged painful goiter, neck pain, fever, after a viral illness, increased ESR | subacute thyroiditis |
| pemberton sign | engorgement of the face and neck veins when simultaneously lifting the arms overhead, secondary to superior vein compressing on the thoracic outlet |
| nodules containing thyroid cancer are hot or cold? | cold nodules |