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Some Gene Facts

Facts about Genes

QuestionAnswer
Size of Human genome 3.2 X 109 bp
Total SNPs > 11 Million
Human vs Chimp 99% similar for SNPs 96% similar overall
Human vs Human 99.9% similar for SNPs
Large INDELS / translocations/ inversions Rare but serious
Tandem repeat polymorphisms Microsatellites (1-6 bp) Minisatellites (11-100 bp) Many cause genetic diseases Used in fingerprinting predicted to be > 100,000
SNPs ~ 1 per 300 bp (one snp per 0.1 to 1 kb length)
Transitions Purines (A,G) interconversions Pyrimidine (C,T) interconversions
Transversions Purine (A,G) <-> Pyramidine (C,T)
most frequent SNP C->T (2/3 ofa all SNPs)
SNP if frequency in population > 1% (Point mutation fixed in the population)
Mutation if < 1%
SNPs ideal genomic markers Dense Easy to assay
Created by: sridharacharya
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