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Repro pharm

toxicities

QuestionAnswer
Danazol weight gain, edema, acne, hirsutism, masculinization, decreased HDL levels
sildenafil, vardenafil HA, flushing, dyspepsia, impaired blue green color vision.
heavy bleeding, GI effects, abdominal pain mifepristone
increased risk of endometrial cancer HRT
danazol mech synthetic androgen that acts as partial agonist at androgen receptors
danazol use endometriosis and hereditary angioedema
tamsulosin m alpha antagonist used for BPH by inhibiting smooth muscle contraction
ritodrine beta 2 agonists that relax the uterus; reduce premature uterine contractions
terbutaline beta 2 agonists that relax the uterus; reduce premature uterine contractions
mifepristone m competitive inhibitor of progestins at progestone receptor
mifepristone u terminate pregnancy. Administered with misoprostol (PGE1)
progestins m bind progesterone receptors, reduce growth, and increase vascularization of endometrium
progestins u OCP, tx endometrial cancer and abnormal uterine bleeding
anastrozole/exemestane aromatase inhibitor used in postmenopausal women with breast cancer
leuprolide GnRH analog with agonist properties when used in pulsatile fashion; atagonist properties when used in continuous fashion (downregulates GnRH receptor in pituitary -> decreased FSH/LH)
leuprolide use infertility (pulsatile), prostate cancer (continuous - use with flutamide), uterine fibroids
Created by: ilovemusic007