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Pharm toxicities
| Question | Answer |
|---|---|
| Adenosine | flushing, hypotension, chest pain effects blocked by theophylline |
| verapamil, diltiazem | constipation, flushing, edema, CV (CHF, AV block, sinus node depression) |
| sotalol | torsades, excessive beta block |
| ibutilide | torsades |
| bretylium | new arryhtmias, hypotension |
| amiodarone | pulmonary fibrosis, hepatotoxicity, hypo/hyperthyroidism, corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neuro effects, constipation, CV effects (bradycardia, heart block, CHF). alters the lipid membrane has class 1,2,3,4 |
| propanolol, esmolol, metoprolol, atenolol, timolol | impotence, exacerbate asthma, mask hypoglycemia in diabetic, bradycardia, AV block, CHF, CNS (sedation, sleepy) |
| metoprolol | increased LDL and increased TGs decreased lipolysis |
| flecainide, propafenone | new arryhtmias, esp post MI prolongs refractory period in AV node hyperkalemia causes increased toxicity |
| lidocaine, mixeltine, tocainide | anesthetic, CNS stimualtion- seizures, depression, CV depression |
| quinidine | cinchonism, headache, tinnitus, occular dysfunction, CNS excitation, hypotension, increased QRS and increased QT Thrombocytopenia torsades |
| procainamide | SLE like syndrome torsades |
| nesiritide | hypotension |
| digoxin | cholinergic- N/V, diarrhea, blurry yellow vision ECG- increased PR, decreased QT, scooping, T wave inversion, arryhtmia, hyperkalemia worsened by renal failure quinidine decreases digoxin clearance |
| fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate) | myositis, hetaptoxicity, cholesterol gall stones |
| bile acid resins (cholestyramine, colestipol, colesevelam) | cholesteral gall stones GI discomfort, decreased absorption of fat soluble vitamins |
| cholesteral absorption blcokers (ezetimibe) | rare increased LFT, hypersensitivity, angioedema, rash |
| niacin | red flushed face hyperglycemia hyperuricemia (gout) |
| HMG-COa reductase inhibitors (lovastatin, pravastatin, simvastatin) | hepatotoxicity, rhabdomyolysis |
| nitroglycerin, isosorbide dinitrate | reflex tachycardia, hypotension, flushing, headache, "Monday disease" because build tolerance then lose tolerance -> tachycardia, dizziness, and headache |
| nitroprusside | Cyanide toxicity |
| diazoxide | hyperglycemia (reduces insulin release) |
| nifedipine, amolodipine, verapamil | cardiac depression, AV block, peripheral edema, flushing, dizziness, constipation |
| hydralazine | compensatory tachycardia (c/i in angina/CAD), fluid retention, nausea, HA, angina, SLE like |
| cocaine, sumatriptan | coronary vasospasm |
| Vancomycin, Adenosine, Niacin, CCB | flushing |
| doxorubicin, daunorubicin | dilated cardiomyopathy |
| class III (Sotalol), class 1A (quinidine) antiarryhtmics, cisapride, erythromycin, TCA's, haloperidol, respiridone, methloquine, macrolides, methadone, protease inhibitors | torsades |
| tx of torsades | Mg2+ |
Created by:
ilovemusic007
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