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Pharm toxicities

QuestionAnswer
Adenosine flushing, hypotension, chest pain effects blocked by theophylline
verapamil, diltiazem constipation, flushing, edema, CV (CHF, AV block, sinus node depression)
sotalol torsades, excessive beta block
ibutilide torsades
bretylium new arryhtmias, hypotension
amiodarone pulmonary fibrosis, hepatotoxicity, hypo/hyperthyroidism, corneal deposits, skin deposits (blue/gray) resulting in photodermatitis, neuro effects, constipation, CV effects (bradycardia, heart block, CHF). alters the lipid membrane has class 1,2,3,4
propanolol, esmolol, metoprolol, atenolol, timolol impotence, exacerbate asthma, mask hypoglycemia in diabetic, bradycardia, AV block, CHF, CNS (sedation, sleepy)
metoprolol increased LDL and increased TGs decreased lipolysis
flecainide, propafenone new arryhtmias, esp post MI prolongs refractory period in AV node hyperkalemia causes increased toxicity
lidocaine, mixeltine, tocainide anesthetic, CNS stimualtion- seizures, depression, CV depression
quinidine cinchonism, headache, tinnitus, occular dysfunction, CNS excitation, hypotension, increased QRS and increased QT Thrombocytopenia torsades
procainamide SLE like syndrome torsades
nesiritide hypotension
digoxin cholinergic- N/V, diarrhea, blurry yellow vision ECG- increased PR, decreased QT, scooping, T wave inversion, arryhtmia, hyperkalemia worsened by renal failure quinidine decreases digoxin clearance
fibrates (gemfibrozil, clofibrate, bezafibrate, fenofibrate) myositis, hetaptoxicity, cholesterol gall stones
bile acid resins (cholestyramine, colestipol, colesevelam) cholesteral gall stones GI discomfort, decreased absorption of fat soluble vitamins
cholesteral absorption blcokers (ezetimibe) rare increased LFT, hypersensitivity, angioedema, rash
niacin red flushed face hyperglycemia hyperuricemia (gout)
HMG-COa reductase inhibitors (lovastatin, pravastatin, simvastatin) hepatotoxicity, rhabdomyolysis
nitroglycerin, isosorbide dinitrate reflex tachycardia, hypotension, flushing, headache, "Monday disease" because build tolerance then lose tolerance -> tachycardia, dizziness, and headache
nitroprusside Cyanide toxicity
diazoxide hyperglycemia (reduces insulin release)
nifedipine, amolodipine, verapamil cardiac depression, AV block, peripheral edema, flushing, dizziness, constipation
hydralazine compensatory tachycardia (c/i in angina/CAD), fluid retention, nausea, HA, angina, SLE like
cocaine, sumatriptan coronary vasospasm
Vancomycin, Adenosine, Niacin, CCB flushing
doxorubicin, daunorubicin dilated cardiomyopathy
class III (Sotalol), class 1A (quinidine) antiarryhtmics, cisapride, erythromycin, TCA's, haloperidol, respiridone, methloquine, macrolides, methadone, protease inhibitors torsades
tx of torsades Mg2+
Created by: ilovemusic007