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HIV drugs 218

QuestionAnswer
HAART 2 NRTI + 1 nnrti or 1 protease inhibitor OR 1 integrase inhibitor
integrase inhibitor raltegravir
raltegravir inhibits HIV genome integration into host cell chromosome by reversibly inhibiting HIV integrase
Raltegravir SE hypecholesterolemia
NNRTI's tenofovir emtricitabine abacavir lamivudine zidovudine didanosine
stavudine NRTI hepativ steatosis
didanosine NRTI pancreatitis peripheral neuropahty
zidovudine bone marrow suppression peripheral neuropathy megaloblastic anemia
abacavir rash
peripheral neuropathy didanosine stavudine
megaloblastic anemia zidovudine
rash NNRTI - nevirapine, efavirenz, delaviridine
hyperglycemia, DM, lipid abnormalities sawuinavir, ritonavir, amprenavir protease inhibitors
protease inhibitors assembly of virions depends on HIV 1 protease (pol gene), which cleaves the polypeptide products of HIV mRNA into their functional parts. THus, protease inhbitiors prevent maturation of new viruses.
rinavir can boost other drug concentrations by inhibitng cytochrome P450
NRTI competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3OH group
NRTI must be phosphrylated by thymidine kinase to be active
pregnancy in HIV zidovudine
NNRTI bind to reverse transcriptase at site different from NRTI. Do not require phosphrylation to be active or compete with nucleotides
integrase inhibitor inhibits HIV genome integration into host cell chromsome by reversibly inhibiting HIV integrase
Created by: ilovemusic007