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NSAIDS

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QuestionAnswer
MOA of NSAIDS inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)
Difference between aspirin and other NSAIDS Aspirin irreversibly inhibits cyclooxygenase
Four main actions of NSAIDS Anti-inflammatory, analgesia, antipyretic and antiplatelet activity
Agent used for closure of patent ductus arteriosus Indomethacin
Aspirin is contraindicated in children with viral infection Potential for development of Reye's syndrome
SE of salicylates Tinnitus, GI bleeding
NSAID also available as an ophthalmic preparation Diclofenac, ketoralac
NSAID available orally, IM and ophthalmically Ketoralac
NSAID that is used for acute condition, such as pre- op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity Ketoralac
Newer NSAID that selectively inhibits COX-2 Celecoxib
COX 2 inhibitors may have reduced risk of Gastric ulcers and GI Bleeding
COX 2 inhibitors should be used cautiously in pts with Pre-existing cardiac or renal disease
Acetaminophen only has Antipyretic and analgesic activity
SE of acetaminophen Hepatotoxicity
Antidote for acetaminophen toxicity N-acetylcysteine
DMARDs are slow acting drugs for Rheumatic disease
Initial DMARD of choice for patients with RA Methotrexate
Drug ofter used in combination with TNF - alpha inhitors for RA Methotrexate
Causes bone marrow suppression Methotrexate
SE of penicillamine Aplastic anemia and renal toxicity
Interferes with activity of T-lymphocytes Hydroxychloroquine
Anti-malarial drug used in rheumatoid arthritis (RA) Hydroxychloroquine
SE of hydroxychloroquine Retinal destruction and dermatitis
MOA of Leflunomide (newer agent) Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis, decreased T cell proliferation and decreased antibody production by B cells
Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha) Adalimumab, infliximab and etanercept
Anti-rheumatic agent also used for ulcerative colitis Sulfasalazine
Anti-rheumatic agent also used for Chron's disease Infliximab
NSAID used in gout Indomethacin
MOA of colchicine (used in acute gout) Selective inhibitor of microtubule assembly
SE of colchicine Kidney and liver toxicity, diarrhea
Agent used to treat chronic gout by increasing uric acid secretion and excretion Probenecid and sulfinpyrazone
Allopurinol treats chronic gout by decreasing uric acid production by inhibiting Xanthine oxidase
Created by: tessah10
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