click below
click below
Normal Size Small Size show me how
NSAIDS
One liners
Question | Answer |
---|---|
MOA of NSAIDS | inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox) |
Difference between aspirin and other NSAIDS | Aspirin irreversibly inhibits cyclooxygenase |
Four main actions of NSAIDS | Anti-inflammatory, analgesia, antipyretic and antiplatelet activity |
Agent used for closure of patent ductus arteriosus | Indomethacin |
Aspirin is contraindicated in children with viral infection | Potential for development of Reye's syndrome |
SE of salicylates | Tinnitus, GI bleeding |
NSAID also available as an ophthalmic preparation | Diclofenac, ketoralac |
NSAID available orally, IM and ophthalmically | Ketoralac |
NSAID that is used for acute condition, such as pre- op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity | Ketoralac |
Newer NSAID that selectively inhibits COX-2 | Celecoxib |
COX 2 inhibitors may have reduced risk of | Gastric ulcers and GI Bleeding |
COX 2 inhibitors should be used cautiously in pts with | Pre-existing cardiac or renal disease |
Acetaminophen only has | Antipyretic and analgesic activity |
SE of acetaminophen | Hepatotoxicity |
Antidote for acetaminophen toxicity | N-acetylcysteine |
DMARDs are slow acting drugs for | Rheumatic disease |
Initial DMARD of choice for patients with RA | Methotrexate |
Drug ofter used in combination with TNF - alpha inhitors for RA | Methotrexate |
Causes bone marrow suppression | Methotrexate |
SE of penicillamine | Aplastic anemia and renal toxicity |
Interferes with activity of T-lymphocytes | Hydroxychloroquine |
Anti-malarial drug used in rheumatoid arthritis (RA) | Hydroxychloroquine |
SE of hydroxychloroquine | Retinal destruction and dermatitis |
MOA of Leflunomide (newer agent) | Inhibiting dihydroorotate dehydrogenase which leads to decreased pyrimidine synthesis, decreased T cell proliferation and decreased antibody production by B cells |
Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha) | Adalimumab, infliximab and etanercept |
Anti-rheumatic agent also used for ulcerative colitis | Sulfasalazine |
Anti-rheumatic agent also used for Chron's disease | Infliximab |
NSAID used in gout | Indomethacin |
MOA of colchicine (used in acute gout) | Selective inhibitor of microtubule assembly |
SE of colchicine | Kidney and liver toxicity, diarrhea |
Agent used to treat chronic gout by increasing uric acid secretion and excretion | Probenecid and sulfinpyrazone |
Allopurinol treats chronic gout by decreasing uric acid production by inhibiting | Xanthine oxidase |