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Local Anesthetics

One liners Local Anesthetics

QuestionAnswer
MOA of local anesthetics (LA's) Block voltage-dependent sodium channels
This may enhance activity of local anesthetics Hyperkalemia
This may antagonize activity of local anesthetics Hypercalcemia
Almost all local anesthetics have this property and sometimes require the administration of vasoconstrictors (ex. Epinephrine) to prolong activity Vasodilation
Local anesthetic with vasoconstrictive property, favored for head, neck, and pharyngeal surgery Cocaine
Longer acting local anesthetics which are less dependent on vasoconstrictors Tetracaine and bupivacaine
These LA's have surface activity Cocaine and benzocaine
Most important toxic effects of most local anesthetics CNS toxicity
Commonly abused LA which has cardiovascular toxicity including severe hypertension with cerebral hemorrhage, cardiac arrhythmias, and myocardial infarction Cocaine
LA causing methemoglobinemia Prilocaine
Created by: tessah10