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pharm 46

male and female hormones

Secondary sex characteristics facial hair, body fat distribution, muscle development
What are drugs that inhibit the conversion of testosterone into potent androgen 5-alpha (a)-dihydrotestosterone (DHT) Androgen Hormone Inhibitors
Androgen therapy is used as replacement therapy for testosterone deficiency, hypogonadism, delayed puberty, postmenopausal metastatic breast carcinoma, premenopausal hormone-dependent metastatic breast carcinoma
Androgen: Adverse Reactions in Men impotence, male pattern baldness
Androgen: Adverse Reactions in Women Amenorrhea; virilization produces male pattern baldness, enlargement of clitoris, acne, deepening of the voice, facial hair growth
Anabolic Steroids: Adverse Reaction in Women fluid and electrolyte imbalances, acne, jaundice, “ ’roid rage”, severe depression, inability to concentrate
Saw palmetto used to relieve the symptoms of BPH, may delay the need for prostate surgery
Saw palmetto actions reduces urinary frequency, increases the flow of urine, and decreases the incidence of nocturia
Saw palmetto dosage 160mg twice daily of standardized extract; one 585-mg capsule or tablet up to three times daily; 20-30 drops up to four times a day (tincture, 1:2 liquid extract)
Saw palmetto considerations not recommended to take as a tea because the active constituents are not water soluble
How soon can improvement be seen with Saw palmetto? 1-3 months; recommended to be taken for 6 months
Male hormone preadministration assessment weight
Anabolic steroids preadministration assessment weight, blood test results for liver function and lipids
Ongoing assessment for androgen or anabolic steroid weigh daily, notify PHCP if significant increase or decrease in weight
Androgen hormone inhibitors and meals can be given without regard to meals
Androgen or anabolic steroid implementation of excess fluid volume monitor fluid and electrolyte disturbances, sodium and water retention, weight; report signs and symptoms of puffy eyelids, dependent edema
Anabolic steroids teaching take drug with food or meals, keep PHCP or clinic visits
Androgen hormone inhibitor teaching pregnant women or those who may become pregnant should not handle these medications (Proscar, Avodart)
Action of estrogens include fluid retention, protein anabolism, thinning of the cervical mucus
Estrogens contribute to conservation of calcium and phosphorus
Estrogens stimulate contraction of fallopian tubes
Estrogen is safer in use with women who have high triglycerides, HTN, diabetes, and migraines
Progestins: Uses treatment of amenorrhea, endometriosis, functional uterine bleeding, and as oral contraceptives
Estrogen dermatologic adverse reaction chloasma and melasma
Estrogen warning hepatic adenoma
Estrogen signs of Excess nausea, bloating, cervical mucorrhea, polyposis, hypertension, migraine headache, breast fullness or tenderness, edema
Estrogen signs of deficiency early or midcycle breakthrough bleeding, increased spotting, hypomenorrhea melasma (discoloration of the skin)
Progestin signs of Excess increased appetite, weight gain, tiredness, fatigue, hypomenorrhea, acne, oily scalp, hair loss, hirsutism (excessive growth of hair), depression, monilial vaginitis, breast regression
Progestin signs of deficiency late breakthrough bleeding, amenorrhea, hypermenorrhea
Female hormone ongoing assessment obtain blood pressure, pulse, respiratory rate and weight, question patient regarding any adverse drug effects, as well as, the result of drug therapy therapeutic effects
Monitoring and managing patient’s needs with excess fluid volume may need to decrease dietary intake of sodium; occasional bloating with meals can be treated with limiting fluids at meals
Monitoring and managing patient’s needs with imbalanced nutrition encourage diet with adequate amounts of protein and carbohydrates, low in fats
Monitoring and managing patient’s needs with ineffective tissue perfusion monitor patient for signs of thrombolic effects; increased risk with patients who have venous insufficiency and who smoke; elevate legs, ambulation
Created by: laotracuata