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Pharm 35

antihyperlipidemic drugs

QuestionAnswer
HMG-CoA reductase Inhibitors: Action inhibits the manufacture of cholesterol or promotes the breakdown of cholesterol
HMG-CoA reductase Inhibitors: Adverse reaction Headache, insomnia, photosensitivity, constipation
HMG-CoA reductase Inhibitors: contraindication with serious liver disorders
Who are at risk for myopathy? patients taking cyclosporine, Asian patients, and patients with severe renal insufficiency
HMG-CoA reductase Inhibitors interaction with macrolides, erythromycin, clarithromycin increased risk of severe myopathy or rhabdomyolysis
HMG-CoA reductase Inhibitors interaction with Amiodarone increased risk for myopathy and for severe myopathy or rhabdomyolysis
HMG-CoA reductase Inhibitors interaction with Niacin increased risk for severe myopathy or rhabdomyolysis
HMG-CoA reductase Inhibitors interaction with Protease inhibitors elevated plasma levels of HMG-CoA reductase inhibitors
HMG-CoA reductase Inhibitors interaction with Verapamil increased risk for myopathy
HMG-CoA reductase Inhibitors interaction with Warfarin increased anticoagulant effect
Bile manufactured and secreted by the liver and stored in the gallbladder, emulsifies fat and lipids as these products pass through the intestine
Cholestyramine powder preparation mixed in 2 to 6 fluid ounces of water or noncarbonated beverage and shaken vigorously; can be mixed with highly fluid soups or pulpy fruits
Colestipol granules must be mixed in liquids, soup, cereals, carbonated beverages, or pulpy fruits; 90 mL of liquid and stir slowly, granules will not dissolve, rinse glass with water and drink all med
Colestipol tablets swallow whole, one at a time, with a full glass of water or other fluid; not chewed, cut or crushed
Bile Acid Resin precautions sipping or holding the liquid preparations in the mouth can cause tooth discoloration or enamel decay
Bile Acid Resin side effects constipation, nausea, abdominal pain, and distention; may subside with continued therapy
Bile Acid Sequestrants:Adverse Reactions Aggravation of hemorrhoids; flatulence; nausea; vitamin K malabsorption
Bile Acid Sequestrants: Precautions with liver disease and kidney disease
Bile Acid Sequestrants interaction with Anticoagulants Decreased effect of the anticoagulant (cholestyramine)
Bile Acid Sequestrants interaction with Thyroid hormone Loss of efficacy of thyroid; also hypothyroidism (particularly with cholestyramine)
Bile Acid Sequestrants interaction with Ursodiol Reduced absorption of ursodiol (particularly cholestyramine and colestipol)
Bile Acid Sequestrants interaction with Aspirin, clindamycin, penicillin G, tetracycline, clofibrate, niacin, digitalis glycosides decresed serum level or decreased GI absorption
Bile Acid Sequestrants interaction with Furosemide, thiazide diuretics, hydrocortisone, methyldopa propranolol, phenytoin decresed serum level or decreased GI absorption
Fibric Acid Derivatives: Action increases escretion of cholesterol in the feces; reduces the production of triglycerides
Fibric Acid Derivatives: Adverse Reactions observe caution while driving
Fibric Acid derivatives: Contraindications in patients with significant hepatic or renal dysfunction or primary biliary cirrhosis
Miscellaneous Antihyperlipidemic Drugs: Action Ezetimibe inhibits absorption of cholesterol
Miscellaneous Antihyperlipidemic Drugs: Adverse Reactions severe generalized flushing of the skin, sensation of warmth, severe itching or tingling
Nursing preadministration assessment of a patient receiving an antihyperlipidemic drug take a dietary history; vital signs; weight
Nursing ongoing assessment of a patient receiving an antihyperlipidemic drug glucose and vital signs
Nursing process: Implementation for Constipation increase fluid intake, eat foods high in dietary fiber, exercise daily, may need to add a stool softener
When should statins be taken? evening
Created by: laotracuata