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Pharm 20 Volume Reg

LECOm Pharm Ch 20 Volume Regulation

(1) ACE-I given as an active drug with active metabolite captopril
(2) ACE-I given as ester prodrug converted to active metabolite enalapril and ramipril
(1) ACE-I given as active drug, excreted unchanged lisinopril
Class causing angioedema, agranulocytosis, neutropenia ACE inhibitors
2 classes used in diabetic neuropathy ACE-I and AT2 R antagonist
Class that can cause rhabdo-, angioedema and rare thrombocytopenia AT-II R blockers
Used in Acutely decompensated heart failure nesiritide
BNP analogue nesiritide
Nesiritide with an ACE inhibitor can cause severe hypotension
Used in SIADH, ADPCKD, and Euvolemic hyponatremia, can cause afib conivaptan
MOA of acetazolamide CA 2 and 4 inhibitor
Can be used in glaucoma acetazolamide
Used as 1st line for edema states loop diuretics
Most potent loop diuretic bumetanide
Used to treat hyper-calcemic and kalemic states loop diuretics
Diuretics help treat hypercalcinuria Thiazides
Diuretics useful with renal cysts? -vaptans
Diuretics that help treat calcium wasting in osteoporosis? Thiazides
Loop diuretic that can be used in Pt’s with sulfa allergy ethycrinic acid
2 Diuretic used for primary aldosteronism? spironolactone and eplerone
Diuretic that may uncover diabetes in a Pt? HCTZ
Diuretic that may induce hypernatremia? mannitol
4 diuretics acting in the collecting duct spirinalactone, eplernone, Amiloride, triamterene
2 Diuretic the inhibits myocardial fibrosis? spirinilactone, eplernone
2 Diuretics used to treat Liddle Syndrome amiloride and triampterine
Diuretic used in nephrogenic diabetes insipidus? thiazides
Diuretic used to treat glaucoma, mountain sickness, and gout? acetazolamide
What type of diuretic can cause hyperkalemia and hyperkalemic metabolic acidosis potassium sparing
Which diuretics are potassium sparing spironolactone, eplernone, amiloride, triamterene
MOA of Amiloride and triamterene inhibit ENaC in collecting ducts
DOC for ascites and edema due to decreased plasma protein/hepatic failure? spironolactone and eplerenone
Diuretic that can cause torsade de pointes? Thiazides
Created by: csheck