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Biology 191 Lect. 2
Biology 191 Lecture 2, Exam 1 Study
| Question | Answer |
|---|---|
| State four documented cases of evolution | 1. Drug resistance in HIV<br />2. Industrial melanism in moths<br />3. Sickle Cell anemia allele in A.A. <br />4. Antibiotic resistance in bacteria |
| Falsifiability | Karl Popper's test for scientific validity: to be considered scientific, a theory must be constructed in such a way that it is capable of being disproved |
| Which evolves: pop or individuals | Populations |
| Population | a group of individuals in a particular place that are capable of interbreeding |
| subpopulation, deme, mendelian population | a locally interbreeding group within a geographic population |
| gene pool | the sum total of genetic information present in a population at any given time |
| genotype frequency | the relative porportion of a particular genotype (# from 0 to 1) |
| Allele Frequency | relative proportion of an aleele at a particular gene locus (# from 0 to 1) |
| Formula for calculating allele frequency, result | q = (NAa + 0.5Naa)/N; for two alleles, p + q = 1<br /> Result: 2 populations with very different genotype frequencies can have the same allele frequencies |
| diploid | 2 alleles at each loci (humans are diploid) |
| Hardy-Weinberg Theorem | Specifies the conditions that must be met for the pop. to remain at equilibrium<br /> - no mutation<br /> - large pop. <br /> - random mating <br /> - no migration into/out of pop./ NO GENE FLOW <br /> - All genotypes survive and rep. =ly well (no select) |
| Given freq of aa, calculate AA, Aa genogype | p^2 + 2pq + q^2 = 1 (take 1/10000, square root to find p. Subtract p from 1 to find q) |
| Agents of Evolutionary Change | - Mutation <br /> - Genetic Drift <br /> - Non-random mating <br /> - gene flow (migration) <br /> - selection (sexual and natural) |
| mutations | any change in DNA sequence, from single base substitutions to deletion or addition of tens or hundreds of bases, to duplication or reorganization of entire chromosomes; ultimate source of genetic variation but usually low in rate |
| Transposable elements | Category of non-coding DNA. Parasitic, selfish genetic elements that accumulate by transposition (copying themselves to new locations in the genome |
| Mutations caused by Transposable elements (4) | - inserting into protein-coding genes <br /> - inserting into regulatory sequences <br /> - carrying segments of host DNA sequences to new locations in genome <br /> - hindering precise chromosomal pairing during cell division |
| 45% of human genome is transposable element sequence | (blank) |
| horizontal transfer(2 ways) | gene transfer from one species to another. 3 ways <br />- conjugation (temporary joining of two bacterial cells and one-way transfer of DNA from donor to recipient using sex pilus) <br />- transformation take up dna from surrounding environment |
| horizontal transfer(1 way) | transduction- transfer of genes from one bacterium to another with bacterial virus acting as carrier of the genes |
| Traits acquired through horizontal transfer: | new metabolic capacities, virulence and antibiotic resistance |
| Conjugative transposons: | horizontal transfer of virulence and antibiotic resistance in CDiff |
| Genetic drift: | changes in allele frequencies due to chance; most important in small populations. <br /> bottleneck , Founder Effect |
| bottleneck Effect | type of genetic drift. Sudden change in environment may drastically reduce population size resulting in change in allele frequencies & potential loss of alleles. Bottlenecks have eliminated genetic variation in some species |
| founder effect | type of genetic drift: when a new population is started by a few members of the original population. Can result in reduced genetic variation compared to orig. population and non-random sample of alleles in original population |
| Founder effect examples | - Tristan de Cunha, british settlement founded by 15 colonists in 1814. they have a high incidence of retenitis pigmentosa (10x higher frequency in Tdec than in Britain)<br /> - Amish of Penn. descended from 200 ppl, suffer higher rates of Ellis-van Crev |
| Non-random mating: | inbreeding (depresses fitness, higher mortality rates, excess of homozygotes),<br /> assortative mating (similar phenotypes mate preferentially, increase homozygosity)<br /> disassortative mating - dissimilar mate pref., increases heter. imp at MHC loci |
| Gene Flow | Movement of aleeles from one pop. to another by (1) migration of fertile indiv. (2) mating of indiv. in adjacent pop. <br /> - Tends to reduce differences in allele freq. between pop. over time. Can oppose natural selection and reduce local adaptation |
| benefits of Gene flow | - restoration of lost alleles through genetic drift <br /> - introduction of new, beneficial alleles |
| Natural Selection (vs sexual) | the superior survival and /or reproduction of some phenotypic variants compared to others under the environmental conditions that prevail at the time |
| Sexual selection (vs natural) | differential reproductive success resulting from competition between members of one sex, usually males, to achieve matings and/or fertilizations ( can result in evolution of exaggerated male traits determental to survival) |
| Selection acts on phenotype of individual and indirectly adapts population to itsenvironment by increasing or maintaining favorable genotypes in gene pool | (blank) |
| Difference between natural selection and evolution by natural selection | Natural selection will not produce evolutionary change in a pop. unless phenotypes differ in their genotypes (variation must have genetic basis) |
| What is different about natural selection as an evolutionary force? | - N.S. produces adaptations that + the ability of individ. to survive/repord. in particular environ. (comp. to others lacking traits) vs. other evo. forces can cause maladaptation<br /> - causes allele frequency changes that proceed indep. at diff loci |