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Study Guide Molecule and Location

Molecule/Cell location
ABC nucleated cells
Acute phase proteins plasma
ADCC Adaptive Response Utilizing NK Cells, PMN’s, and Eosinophils
Adjuvent Chemical introduced into the Immune system from external
AID (Activation-Induced Cytidine Deaminase) Activated B Cells
Alpha beta-TCR T cells
Alpha-fetoprotein Fetal Plasma Protein
ANA (AntiNuclear Ab) Cytoplasm and blood serum
Antigen Free-floating or cell surface bound
Artemis Enzyme found in T and B Cells
BCR B cells
-microglobulin All Nucleated Cells
B1 Cells Unconventional polyspecific BCells of the Pleural and Peritoneal Cavities
B2 Cells Conventional B Cells
B7 Activated APC’s
B7-1 (AKA “CD80”) Thymic Dendritic and medullary Epithelial cells
B7-2 (AKA “CD86”) Thymic Dendritic and Medullary Epithelial Cells
c-FLIP (cellular FLICE-like Inhibitory Protein) Lymphocytes and DC’s
C Reactive Protein Acute phase Protein
Calcineurin Intracellular signaling molecule found in T cells
Calmodulin (“CALcium MODULated protein”) All Eukaryotic Cells
C1-inhibitor Acute Phase Protein
C1 (C1qr2s2) Serum as part of the innate response (classical complement)
C1q Serum as a part of the innate response (classical complement)
C1r Serum as part of the innate response (classical complement)
C1s Serum as part of the innate response (classical complement)
C2 Serum as part of the innate response (classical complement)
C3 Serum as part of the innate response (alternative complement)
C3aC4aC5a Serum as part of the innate response (low M.W. cleavage products of the cascade)
C3bBb Serum as part of the innate response (complement)
C5 Serum as part of the innate response (complement)
C6 Serum as part of the innate response (complement)
C7 Serum as part of the innate response (complement)
C8 Serum as part of the innate response (complement)
C9 Serum as part of the innate response (complement)
C5 convertase (C3bBb) Serum as part of the innate response (complement)
CCL 1 Binds CCR8
CCL 2 Binds CCR2
CCL 3 Binds CCR1 and CCR5
CCL4 Binds CCR5
CCL5 Binds CCR1, 3, and 5
CCL7 Binds CCR1, 2, and 3
CCL8 Binds CCR3 and CCR5
CCL9/CCL10 Binds CCR1
CCL11 Binds CCR3
CCL12 Binds CCR2
CCL13 Binds CCR2 and CCR3
CCL14 Binds CCR1 and CCR5
CCL15 Binds CCR1 and CCR3
CCL16 Binds CCR1 and CCR2
CCL17 Binds CCR4
CCL18 ?
CCL19 Binds CCR7
CCL20 Binds CCR6
CCL21 Binds CCR7
CCL22 Binds CCR4
CCL23 Binds CCR1
CCL24 Binds CCR3
CCL25 Binds CCR9
CCL26 Binds CCR3
CCL27 Binds CCR10
CCL28 Binds CCR10
CD1 (a, b, and c) Thymocytes, DC’s
CD1d Thymocytes, DC’s, intestinal epithelial cells,
CD1e DC’s
CD2 T cells and NK cells
CD3 (, or ) T cells
CD4 Class II MHC-restricted T cells, monocytes, and macrophages
CD5 Surface of B1 Cells in Mice
CD8 Class I MHC-restricted T cells
CD11a (LFA-1) Leukocytes
CD11b See “CR3”
CD11c See “CR4”
CD14 Monocytes, macrophages,granulocytes
CD16a NK cells, macrophages
CD16b Neutrophils
CD18 See “CR3” and “CR4”
CD20 Surface of B1 Cells in Humans
CD21 See “CR2”
CD23 Activated B cells, monocytes, and macrophages
CD25 Activated T and B cells; regulatory T cells; activated macrophages
CD28 Thymocytes
CD34 Precursors of hemopoietic cells, endothelial cells in high endothelial venules
CD35 See “CR1”
CD40 B cells, macrophages, DC’s, endothelial cells
CD43 Leukocytes (except circulating B cells)
CD45 Hemapoietic cells
CD49d Lymphocytes, leukocytes, thymocytes
CD54 Endothelial cells and lymphocytes
CD58 Broad cellular distribution
CD59 Blood cells, endothelial and epithelial cells
CD62L (L-selectin) Leukocytes
CD64 See “Fc gamma R1”
CD72 B Cells
CD74 MHC Class II-expressing APC’s
CD80 (B7-1) DC’s, activated B cells and macrophages
CD86 (B7-2) B cells, monocytes, DC’s, and some T cells
CD95 See Fas”
CD95L See “FasL”
CD106 (VCAM-1) Activated endothelial cell surfaces
CD152 (CTLA-4) CD4 cells
CD154 Activated CD4+ T cells
CDR Ig and TCR moleculesCLIP (Class II-associated
Invariant chain Peptide) Endosomes of APC’s
Combinatorial Joining B cells
CR1 (CD35)“Complement Receptor1” Mononuclear phagocytes, neutrophils, lymphocytes, erythrocytes, eosinophils, FDC’s
CR2 (CD21)“Complement Receptor2” B lymphocytes, FDC’s, nasopharyngeal epithelium
CR3 (CD11b /CD18) “Complement Receptor3” Mononuclear phagocytes, neutrophils, NK cells
CR4 (CD11c /CD 18)“Complement Receptor 4” Mononuclear phagocytes, neutrophils, NK cells
CSF Hemopoietic stem cells
CTLA-4 See “CD152”
CXCL1 Attaches to CXCR2
CXCL2 Attaches to CXCR2
CXCL3 Attaches to CXCR2
CXCL4 Attaches to CXCR3B
CXCL5 Attaches to CXCR2
CXCL6 Attaches to CXCR1, CXCR2
CXCL7 Attaches to CXCR2
CXCL8 Attaches to CXCR1, CXCR2
CXCL9 Attaches to CXCR3
CXCL10 Attaches to CXCR3, CXCR3B
CXCL11 Attaches to CXCR3
CXCL12 Attaches to CXCR4
CXCL13 Attaches to CXCR5
CXCL14 ?
CXCL16 Attaches to CXCR6
DAF (Decay AcceleratingFactor) Blood cells, endothelial andmepithelial cells
Dendritic cell Innate system – found in tissues in contact with external environment
Eosinophils Circulating granulocytes
Epitopes Antigenic cell surfaces
Factor B Serum as part of the innate response (complement)
Factor D Serum as part of the innate response (complement)
Factor P (Properdin) Serum protein as part of the innate response (complement)
Fas (CD95)surfaces T cells and many other cell
FasL (APO-1 or APOL) Activated T cells
Fc Ab
Fc-epsilon I receptor IgE
Fc-epsilon II receptor IgE
Fc-gamma receptor(CD64) IgG
FDC (Follicular DendriticCell) Follicles of 2oand 3o lymphoid organs (not true DC’s – originate from a different cell line)
Fyn Cell membrane
Gamma/delta cell(gamma delta TCR) T cell surface markers
G-CSF (Granulocyte – ColonyStimulating Factor) Produced by activated T cells, macrophages, and endothelial cells at site of infection
GM-CSF(Granulocyte-Monocyte- Colony Stimulating Factor) Produced by activated T cells, macrophages, endothelial cells, and stromal fibroblasts at site of infection
Gram (+) Bacterial cell wall
Gram (-) Bacterial cell wall
Hairpin loop Nucleic acids
HLA-B27 All nucleated cells
HLA-B35 All nucleated cells
HLA-B57 All nucleated cells
IFN (Types I and II) Glycoprotein of the non-specific (innate) response
IFN-alpha A Type I IFN produced by virus infected leukocytes
IFN-beta A Type I IFN produced by virus infected fibroblasts
IFN-gamma A Type II IFN produced by activated T cells (TH1 and CD8) and NK cells
IgA Produced primarily by MALT
IgD BCR component
IgE Produced by plasma cells of the specific (adaptive) response
IgG Produced by plasma cells of the specific (adaptive) response
IgM Produced by plasma cells of the specific (adaptive) response; BCR
Ig-and Membrane Ig on B cells (BCR)
Interleukin (IL) Historically meant to be produced by a leukocyte
Il-1 Produced mainly by activated mononuclear phagocytes; innate system
IL-1Ra (Interleukin-1 Recepto antagonist) Produced by mononuclear phagocytes
IL-2 Activated T cells
IL-3 CD4 T cells
IL-4 TH2 Cells
IL-5 TH2 Cells and activated mast cells
IL-6 Many different cell typesincluding: mononuclear phagocytes, endothelial cells, and fibroblasts
IL-7 Bone marrow stromal cells
IL-10 Activated macrophages and some CD4 cells
IL-12 Mononuclear phagocytes and DC’s
IL-15 Mainly produced by mononuclear phagocytes in response to viral infections
IL-17 TH17 cells
IL-18 Macrophages
Immunoglobulin Produced by plasma cells of the specific (adaptive) response
Innate Branch of the immune system involving epithelial barriers, neutrophils and macrophages, NK cells, cytokines, and complement
iNOS (inducible Nitric Oxide Synthetase) Activated macrophages
Invariant chain Endoplasmic reticulum
Isotype Serum or surface of B cell (BCR)
JAK/STAT signaling pathway Cell surfaces and intacellular signaling
Junctional Diversity Serum or surface of B cell (BCR)
Kinase (AKA “phosphotransferase”) Various
Large granular lymphocyte NK cell
Leukotriene Many cell types; mast cells
LFA-1 (Leukocyte Function Associated Antigen 1) (CD11a) See “CD11a”
Lipid A Gram (-) bacteria
LPS (Endotoxin) Gram (-) bacteria
LMP-2 and LMP-7 Intracellular catalytic subunits of the proteasome
LT (Lymphotoxin, TNF-) Produced by T cells
M cells GALT
Macrophage Tissues; innate and adaptive response
MALT Mucosal surfaces
Mannose Pathogen cell surfaces
Mannan Binding Lectin(or Mannose Binding Lectin) Complement Pathway
Mast cell Leukocyte of the adaptive system
MAP Kinase (“Mitogen Activated Protein Kinase”) Protein cascade
Mitogen Externally introduced chemical
MHC-I All nucleated cells
MHC-II Associated with professional APC’s (Antigen presenting Cells)
NKT cells Peripheral blood
N-Region Diversity (N nucleotides) Lymphocyte nucleus
NADPH oxidase Phagocytic cells
NFAT (Nuclear Factor of Activated T cells) Lymphocytes, leukocytes, and nonimmune cells (such as muscle, neuron)
NFKB (“Nuclear Factor kappa B”) Originally thought to be in only mature B cells and plasma cells, now known to exist in all cells types
NK Cell Innate immune system
Papain Cysteine protease produced by papaya
Pepsin Digestive protease from mammalian chief cells
Plasma cell Adaptive immune system
Properdin (Factor P) Serum protein as part of the innate response (complement)
Proteasome Intracellular protein complexes
RAG 1 and 2 Lymphocytes
Rheumatoid Factor Serum
Somatic Hypermutation B cells
Superantigen Originate from bacteria as highly virulent toxin (active in minimal pg/ml amounts)
Superoxide radical Intracellular reactive oxygen species; phagocytic cells
TAP1,2 Cytoplasm of all eukaryotic cells
TCR Surface of T cells
TGF-beta Produced by many cell types
TH0 Periphery; cellular immunity
TH1 Periphery; cellular immunity
TH2 Periphery; cellular immunity
TH17 Periphery; cellular immunity
TLR (Toll-Like Receptors) Surfaces of innate system cells that recognize and respond to antigens
TNF-alpha Activated mononuclear phagocytes
TNF-beta See “Lymphotoxin”
VCAM-1 (Vascular Cell Adhesion Molecule – 1) See “CD 106”
VLA-4 (Very Late Antigen) See “CD49d”
Created by: charliebucket



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