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Immunology
Study Guide Molecule and Location
| Question | Answer |
|---|---|
| Molecule/Cell | location |
| ABC | nucleated cells |
| Acute phase proteins | plasma |
| ADCC | Adaptive Response Utilizing NK Cells, PMN’s, and Eosinophils |
| Adjuvent | Chemical introduced into the Immune system from external |
| AID (Activation-Induced Cytidine Deaminase) | Activated B Cells |
| Alpha beta-TCR | T cells |
| Alpha-fetoprotein | Fetal Plasma Protein |
| ANA (AntiNuclear Ab) | Cytoplasm and blood serum |
| Antigen | Free-floating or cell surface bound |
| Artemis | Enzyme found in T and B Cells |
| BCR | B cells |
| -microglobulin | All Nucleated Cells |
| B1 Cells | Unconventional polyspecific BCells of the Pleural and Peritoneal Cavities |
| B2 Cells | Conventional B Cells |
| B7 | Activated APC’s |
| B7-1 (AKA “CD80”) | Thymic Dendritic and medullary Epithelial cells |
| B7-2 (AKA “CD86”) | Thymic Dendritic and Medullary Epithelial Cells |
| c-FLIP (cellular FLICE-like Inhibitory Protein) | Lymphocytes and DC’s |
| C Reactive Protein | Acute phase Protein |
| Calcineurin | Intracellular signaling molecule found in T cells |
| Calmodulin (“CALcium MODULated protein”) | All Eukaryotic Cells |
| C1-inhibitor | Acute Phase Protein |
| C1 (C1qr2s2) | Serum as part of the innate response (classical complement) |
| C1q | Serum as a part of the innate response (classical complement) |
| C1r | Serum as part of the innate response (classical complement) |
| C1s | Serum as part of the innate response (classical complement) |
| C2 | Serum as part of the innate response (classical complement) |
| C3 | Serum as part of the innate response (alternative complement) |
| C3aC4aC5a | Serum as part of the innate response (low M.W. cleavage products of the cascade) |
| C3bBb | Serum as part of the innate response (complement) |
| C5 | Serum as part of the innate response (complement) |
| C6 | Serum as part of the innate response (complement) |
| C7 | Serum as part of the innate response (complement) |
| C8 | Serum as part of the innate response (complement) |
| C9 | Serum as part of the innate response (complement) |
| C5 convertase (C3bBb) | Serum as part of the innate response (complement) |
| CCL 1 | Binds CCR8 |
| CCL 2 | Binds CCR2 |
| CCL 3 | Binds CCR1 and CCR5 |
| CCL4 | Binds CCR5 |
| CCL5 | Binds CCR1, 3, and 5 |
| CCL7 | Binds CCR1, 2, and 3 |
| CCL8 | Binds CCR3 and CCR5 |
| CCL9/CCL10 | Binds CCR1 |
| CCL11 | Binds CCR3 |
| CCL12 | Binds CCR2 |
| CCL13 | Binds CCR2 and CCR3 |
| CCL14 | Binds CCR1 and CCR5 |
| CCL15 | Binds CCR1 and CCR3 |
| CCL16 | Binds CCR1 and CCR2 |
| CCL17 | Binds CCR4 |
| CCL18 | ? |
| CCL19 | Binds CCR7 |
| CCL20 | Binds CCR6 |
| CCL21 | Binds CCR7 |
| CCL22 | Binds CCR4 |
| CCL23 | Binds CCR1 |
| CCL24 | Binds CCR3 |
| CCL25 | Binds CCR9 |
| CCL26 | Binds CCR3 |
| CCL27 | Binds CCR10 |
| CCL28 | Binds CCR10 |
| CD1 (a, b, and c) | Thymocytes, DC’s |
| CD1d | Thymocytes, DC’s, intestinal epithelial cells, |
| CD1e | DC’s |
| CD2 | T cells and NK cells |
| CD3 (, or ) | T cells |
| CD4 | Class II MHC-restricted T cells, monocytes, and macrophages |
| CD5 | Surface of B1 Cells in Mice |
| CD8 | Class I MHC-restricted T cells |
| CD11a (LFA-1) | Leukocytes |
| CD11b | See “CR3” |
| CD11c | See “CR4” |
| CD14 | Monocytes, macrophages,granulocytes |
| CD16a | NK cells, macrophages |
| CD16b | Neutrophils |
| CD18 | See “CR3” and “CR4” |
| CD20 | Surface of B1 Cells in Humans |
| CD21 | See “CR2” |
| CD23 | Activated B cells, monocytes, and macrophages |
| CD25 | Activated T and B cells; regulatory T cells; activated macrophages |
| CD28 | Thymocytes |
| CD34 | Precursors of hemopoietic cells, endothelial cells in high endothelial venules |
| CD35 | See “CR1” |
| CD40 | B cells, macrophages, DC’s, endothelial cells |
| CD43 | Leukocytes (except circulating B cells) |
| CD45 | Hemapoietic cells |
| CD49d | Lymphocytes, leukocytes, thymocytes |
| CD54 | Endothelial cells and lymphocytes |
| CD58 | Broad cellular distribution |
| CD59 | Blood cells, endothelial and epithelial cells |
| CD62L (L-selectin) | Leukocytes |
| CD64 | See “Fc gamma R1” |
| CD72 | B Cells |
| CD74 | MHC Class II-expressing APC’s |
| CD80 (B7-1) | DC’s, activated B cells and macrophages |
| CD86 (B7-2) | B cells, monocytes, DC’s, and some T cells |
| CD95 | See Fas” |
| CD95L | See “FasL” |
| CD106 (VCAM-1) | Activated endothelial cell surfaces |
| CD152 (CTLA-4) | CD4 cells |
| CD154 | Activated CD4+ T cells |
| CDR | Ig and TCR moleculesCLIP (Class II-associated |
| Invariant chain Peptide) | Endosomes of APC’s |
| Combinatorial Joining | B cells |
| CR1 (CD35)“Complement Receptor1” | Mononuclear phagocytes, neutrophils, lymphocytes, erythrocytes, eosinophils, FDC’s |
| CR2 (CD21)“Complement Receptor2” | B lymphocytes, FDC’s, nasopharyngeal epithelium |
| CR3 (CD11b /CD18) “Complement Receptor3” | Mononuclear phagocytes, neutrophils, NK cells |
| CR4 (CD11c /CD 18)“Complement Receptor 4” | Mononuclear phagocytes, neutrophils, NK cells |
| CSF | Hemopoietic stem cells |
| CTLA-4 | See “CD152” |
| CXCL1 | Attaches to CXCR2 |
| CXCL2 | Attaches to CXCR2 |
| CXCL3 | Attaches to CXCR2 |
| CXCL4 | Attaches to CXCR3B |
| CXCL5 | Attaches to CXCR2 |
| CXCL6 | Attaches to CXCR1, CXCR2 |
| CXCL7 | Attaches to CXCR2 |
| CXCL8 | Attaches to CXCR1, CXCR2 |
| CXCL9 | Attaches to CXCR3 |
| CXCL10 | Attaches to CXCR3, CXCR3B |
| CXCL11 | Attaches to CXCR3 |
| CXCL12 | Attaches to CXCR4 |
| CXCL13 | Attaches to CXCR5 |
| CXCL14 | ? |
| CXCL16 | Attaches to CXCR6 |
| DAF (Decay AcceleratingFactor) | Blood cells, endothelial andmepithelial cells |
| Dendritic cell | Innate system – found in tissues in contact with external environment |
| Eosinophils | Circulating granulocytes |
| Epitopes | Antigenic cell surfaces |
| Factor B | Serum as part of the innate response (complement) |
| Factor D | Serum as part of the innate response (complement) |
| Factor P (Properdin) | Serum protein as part of the innate response (complement) |
| Fas (CD95)surfaces | T cells and many other cell |
| FasL (APO-1 or APOL) | Activated T cells |
| Fc | Ab |
| Fc-epsilon I receptor | IgE |
| Fc-epsilon II receptor | IgE |
| Fc-gamma receptor(CD64) | IgG |
| FDC (Follicular DendriticCell) | Follicles of 2oand 3o lymphoid organs (not true DC’s – originate from a different cell line) |
| Fyn | Cell membrane |
| Gamma/delta cell(gamma delta TCR) | T cell surface markers |
| G-CSF (Granulocyte – ColonyStimulating Factor) | Produced by activated T cells, macrophages, and endothelial cells at site of infection |
| GM-CSF(Granulocyte-Monocyte- Colony Stimulating Factor) | Produced by activated T cells, macrophages, endothelial cells, and stromal fibroblasts at site of infection |
| Gram (+) | Bacterial cell wall |
| Gram (-) | Bacterial cell wall |
| Hairpin loop | Nucleic acids |
| HLA-B27 | All nucleated cells |
| HLA-B35 | All nucleated cells |
| HLA-B57 | All nucleated cells |
| IFN (Types I and II) | Glycoprotein of the non-specific (innate) response |
| IFN-alpha | A Type I IFN produced by virus infected leukocytes |
| IFN-beta | A Type I IFN produced by virus infected fibroblasts |
| IFN-gamma | A Type II IFN produced by activated T cells (TH1 and CD8) and NK cells |
| IgA | Produced primarily by MALT |
| IgD | BCR component |
| IgE | Produced by plasma cells of the specific (adaptive) response |
| IgG | Produced by plasma cells of the specific (adaptive) response |
| IgM | Produced by plasma cells of the specific (adaptive) response; BCR |
| Ig-and Membrane Ig on B cells (BCR) | |
| Interleukin (IL) | Historically meant to be produced by a leukocyte |
| Il-1 | Produced mainly by activated mononuclear phagocytes; innate system |
| IL-1Ra (Interleukin-1 Recepto antagonist) | Produced by mononuclear phagocytes |
| IL-2 | Activated T cells |
| IL-3 | CD4 T cells |
| IL-4 | TH2 Cells |
| IL-5 | TH2 Cells and activated mast cells |
| IL-6 | Many different cell typesincluding: mononuclear phagocytes, endothelial cells, and fibroblasts |
| IL-7 | Bone marrow stromal cells |
| IL-10 | Activated macrophages and some CD4 cells |
| IL-12 | Mononuclear phagocytes and DC’s |
| IL-15 | Mainly produced by mononuclear phagocytes in response to viral infections |
| IL-17 | TH17 cells |
| IL-18 | Macrophages |
| Immunoglobulin | Produced by plasma cells of the specific (adaptive) response |
| Innate | Branch of the immune system involving epithelial barriers, neutrophils and macrophages, NK cells, cytokines, and complement |
| iNOS (inducible Nitric Oxide Synthetase) | Activated macrophages |
| Invariant chain | Endoplasmic reticulum |
| Isotype | Serum or surface of B cell (BCR) |
| JAK/STAT signaling pathway | Cell surfaces and intacellular signaling |
| Junctional Diversity | Serum or surface of B cell (BCR) |
| Kinase (AKA “phosphotransferase”) | Various |
| Large granular lymphocyte | NK cell |
| Leukotriene | Many cell types; mast cells |
| LFA-1 (Leukocyte Function Associated Antigen 1) (CD11a) | See “CD11a” |
| Lipid A | Gram (-) bacteria |
| LPS (Endotoxin) | Gram (-) bacteria |
| LMP-2 and LMP-7 | Intracellular catalytic subunits of the proteasome |
| LT (Lymphotoxin, TNF-) | Produced by T cells |
| M cells | GALT |
| Macrophage | Tissues; innate and adaptive response |
| MALT | Mucosal surfaces |
| Mannose | Pathogen cell surfaces |
| Mannan Binding Lectin(or Mannose Binding Lectin) | Complement Pathway |
| Mast cell | Leukocyte of the adaptive system |
| MAP Kinase (“Mitogen Activated Protein Kinase”) | Protein cascade |
| Mitogen | Externally introduced chemical |
| MHC-I | All nucleated cells |
| MHC-II | Associated with professional APC’s (Antigen presenting Cells) |
| NKT cells | Peripheral blood |
| N-Region Diversity (N nucleotides) | Lymphocyte nucleus |
| NADPH oxidase | Phagocytic cells |
| NFAT (Nuclear Factor of Activated T cells) | Lymphocytes, leukocytes, and nonimmune cells (such as muscle, neuron) |
| NFKB (“Nuclear Factor kappa B”) | Originally thought to be in only mature B cells and plasma cells, now known to exist in all cells types |
| NK Cell | Innate immune system |
| Papain | Cysteine protease produced by papaya |
| Pepsin | Digestive protease from mammalian chief cells |
| Plasma cell | Adaptive immune system |
| Properdin (Factor P) | Serum protein as part of the innate response (complement) |
| Proteasome | Intracellular protein complexes |
| RAG 1 and 2 | Lymphocytes |
| Rheumatoid Factor | Serum |
| Somatic Hypermutation | B cells |
| Superantigen | Originate from bacteria as highly virulent toxin (active in minimal pg/ml amounts) |
| Superoxide radical | Intracellular reactive oxygen species; phagocytic cells |
| TAP1,2 | Cytoplasm of all eukaryotic cells |
| TCR | Surface of T cells |
| TGF-beta | Produced by many cell types |
| TH0 | Periphery; cellular immunity |
| TH1 | Periphery; cellular immunity |
| TH2 | Periphery; cellular immunity |
| TH3 | GALT |
| TH17 | Periphery; cellular immunity |
| TLR (Toll-Like Receptors) | Surfaces of innate system cells that recognize and respond to antigens |
| TNF-alpha | Activated mononuclear phagocytes |
| TNF-beta | See “Lymphotoxin” |
| VCAM-1 (Vascular Cell Adhesion Molecule – 1) | See “CD 106” |
| VLA-4 (Very Late Antigen) | See “CD49d” |
Created by:
charliebucket
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