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DIT molecularbio
DNA/RNA/proteins
| Question | Answer |
|---|---|
| location, pathway and nitrogen source of CPS I | mitochondria, urea cycle, ammonia |
| location, pathway and nitrogen source of CPS II | cytosol, pyrimidine synthesis, glutamine |
| rate limiting step in purine synthesis | glutamine-PRPP amidotransferase |
| rate limiting step in pyrimidine synthesis | CPS II |
| sources of carbons in the formation of purines | CO2, THF, glycine |
| sources of carbon in pyrimidine synthesis | CO2, aspartate |
| what accounts for the positive charge of histones? | Arg and Lys |
| what accounts for the negative charge of DNA? | phosphate groups |
| inhibits ribonucleotide reductase | hydroxyurea |
| inhibits dihydrofolate reductase | methotrexate, trimethoprim |
| inhibits thymidylate synthase | 5FU |
| inhibits inosine monophosphate dehydrogenase | mycophenolate |
| inhibits PRPP synthetase | 6 mercaptopurine |
| FTT, megaloblastic anemia that doesn't improve with B12 or folate | orotic aciduria |
| how does UV light damage DNA | creates a thymine dimer on the same strand of DNA |
| replicates lagging strand, synthesizes RNA primer (euk) | DNA pol alpha |
| repairs DNA (euk) | beta, epsilon DNA pol |
| replicates mitochondrial DNA (Euk) | gamma DNA pol |
| replicates leading strand DNA (euk) | delta DNA pol |
| DNA repair defect. hypersensitivy to UV light | xeroderma pigmentosum |
| DNA repair defect. sensitivity to ionizing radiation, immunodeficiency, ataxia beginning at 1-2 yo | ataxia-telangiectasia |
| DNA repair defect. hypersensitivty to sunlight, leukemia and lymphoma, onset at 25yo | bloom's syndrome |
| inhibits 50s peptidyltransferase | chloramphenicol and streptogranins |
| blocks 50s, blocking translocation | macrolides, linezolid |
| binds 30s, preventing attachment of tRNA | tetracycline |
| inhibits prokaryotic RNA polymerase | rifampin |
| inhibits prokaryotic topoisomerase | flouroquinolones |
| inhibits prokaryotic dihydrofolate reductase | trimethoprim |
| 3 ways cells break down proteins | ubiquitin, lysosomes, ca dependent enzymes |
| catalyzes peptide bond formation during protein synthesis | peptidyl transferase |
| what enzyme matches amino acids to tRNA | aminoacyl tRNA synthestase |
| mRNA stop codons | UAG, UAA< UGA |
| RNA pol in eukaryotes | 1 rRNA, 2 mRNA, 3tRNA |
| what amino acid frequently has more coding sequences in the mRNA than are represented in the peptide that is created from that mRNA | methionine |
| How is hnRNA processed before it leaves the nucleus | 5' cap, poly-A tail, intron splice |
| What is the characteristic sequence of the promotor region? | RNA pol, TFs, 25 TATA 75 CAAT |
| what does a mutation in the promotor sequence cause? | decrease in the amount of gene transcribed |
| What enzyme is deficient in Lesch-Nyhan syndrome? | HGPRT |
| What is the treatment for lesch-nyhan | you can treat the gout with allopurinol |
| what structural motifs allow for proteins to bind to DNA? | helix loop heliz, helix turn helix, zinc finger, leucine zipper |
Created by:
kayjames
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