Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

NURS 572 Ch 34

Pharm Ch 34 Sedative, hypnotics, BNZ

QuestionAnswer
MOA of true BNZ Bnz binds WITH GABA at receptor-->activates Cl- channel-->Cl- rushes in to make cell more negative (hyperpolarized) --> decreased firing --> inhibitory effect
do BNZs activate GABA receptors? no - BNZ ONLY POTENTIATE the actions of GABA, which must be present
do BNZ cross BBB yes, lipid soluble with long-acting metabolitesw
low dose of BNZ used in treatment of anxiety, panic disorder, muscle spasms
higher dose of BNZ used in reatment of insomnia, pre-op (+ anterograde amnesia), seizures
BNZ ADRs CNS depression, resp depression, anterograde amnesia
unusual ADRs BNZ paradoxical sundowning effect, esp in elderly
Special concerns BNZ Category D, Interacts with CNS depressants, CYP 450 enzyme interactions
what is are BNZ-like that binds WITH GABA resulting in a built-in anti-overdose feature zolpidem (zaleplon & eszoplicone ACT like BNZs but use different MOA)
zolpidem indicated for ONLY sleep latency, prolongs duration somewhat. lacks muscle relaxant, anxiolytic, anti-seizure
zaleplon MOA diff chemical class with MOA similar to BNZ
zaleplon indicated for latency ONLY ---muscle relax, anxiolytic, anti-seizure
unique to zaleplon half-life is 1 hour, very short acting, only for sleep latency
eszopiclone MOA not chemically related to others in class, but has similar MOA at GABA receptor
indication for eszopiclone sleep DURATION only - half-life of 6 hours
Class of drug - ramelteon Melatonin-receptor agonist M1M2 in SCN suprachiasmatic nucleus (body's master circadian clock). Pineal gland increases melatonin at dark. this drug has 15 fold increase in affinity for MT1 receptors than melatonin
Unusual features ramelteon Category C, metabolites half-life 2-5 hours where drug half life only 1-3 hours
Unusual ADRs ramelteon potential for decreased testosterone, increase in prolactin
Barbiturates - why no longer used can bind WITHOUT GABA which means OD possible which depresses CNS --> decreased resp --> coma, death
name one atypical antidepressent, with ADR of priaprism, used for hypnotic SE trazadone
name 2 first generation antihistamines used for their sedative SE diphenhydramine, doxylamine
Created by: lorrelaws
Popular Nursing sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards