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DIT fuel usage
in feeding vs. fasting states
| Question | Answer |
|---|---|
| What fuels are produced in the post absorptive period? | glucose from liver, FA from adipose tissue |
| What fuels are used in post absorptive period | mm, brain, and tissues use GLUCOSE |
| when does gluconeogenesis begin? | 4 - 6 hrs after the last meal |
| when does gluconeogenesis become fully active? | when gllycogen stores are depleted - 10 to 18 hours after the last meal. |
| What fuels are produced in early starvation (24 hours after last meal) | glucose from gluconeogenesis, with some glycogen from glycogenolysis; FA from adipose |
| What fuels are used in early starvation (24 hrs post) | brain uses glucose, mm + use some glucose but mostly FA |
| 48 hrs post meal what fuels are produced? | Glucose from gluconeogenesis, FA from adipose, KB from liver |
| 48 hrs post meal what fuel is used? | Brain uses glucose and some KBs; mm + use mostly FA and some KBs |
| what metabolic scenario favors the synthesis of KBs | excess acetyl CoA from FA metabolism |
| What can't use KBs? | RBCs |
| in prolonged starvation, what fuel is produced? | glucose, FA, KBs |
| in prolonged starvation what fuel is used | brain uses KBs, mm + use FA and some KBs |
| 95% of energy from glucose (2/3 glycogen, 1/3 gluconeogenesis); 5% of energy from ketone bodies | overnight fast |
| 60% of energy from ketone bodes, 40% from glucosee (gluconeogenesis) | 3 day fast |