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DIT heme quiz

QuestionAnswer
age distribution of Hodgkin's lymphoma bimodal distribution
age distribution of non-Hodgkin's lymphoma 20-40s
most common type of non-hodgkin's lymphoma in adults Diffuse large B cell lymphoma
most common type of non-Hodgkin's lymphoma in kids lymphoblastic lymphoma
lab findings in DIC decreased platelet count, increased Bleeding Time, PT, PTT, and D-dimer
What is the structure of HbH beta4
what disease results in HbH production alpha thalassemia w/ 3 deletions
what is the structure of Hb Barts gamma4
what disease results in Hb Barts production alpha thalassemia w/ 4 deletions
+ Ham's test PNH
Heinz bodies G6PD deficiency
basophilic stippling (TAIL) Thalassemia, ACD, iron def, LEAD POISONING
+ osmotic fragility test hereditary spherocytosis
+ DEB test Fanconi anemia
D-dimers DIC, DVT, Budd-chiari
+ coombs a/i hemolytic anemia
- coombs nL hemolytic anemia
+ ristocetin test von willebrands disease
causes of aplastic anemia RADIATION, drugs(benzene, chlorpromazine, alkylating agents), viruses(PVB19, EBV, HIV, HCV), fanconi's anemia, idiopathic
A pt has hypercalcemia from the most common primary tumor in the bones of adults. Lab findings? (MM) M spike, bence jones protein, anemia, roleaux, punched out lytic bone lesions
findings a/w hereditary spheroctosis osmotic fragility, sm RBCs with no central pallor, increased MCHC, increased RDW, splenomegaly, aplastic crisis, pigmented gallstones, jaundince, cooombs negative
Lab findings in iron def anemia increased TIBC, decreased ferritin, decreased FE/TIBC
Lab findings in thalassemia Fe NL, target cells
a child anemic since birth has now been cured with splenectomy. what did it have? hereditary spherocytosis
danger of giving folate alone to a pt with macrocytic megaloblastic anemia it'll mask B12 deficiency
anemia, hypercalcemia, bone pain and plasma cells (lg, round off center nucleus) in bone marrow biopsy MM, nothing in urinalysis, M spike on UPEP
neoplasms a/w AIDS kaposi sarcoma, HPV, primary CNS lymphoma, NOn-hodgkins lymphoma
A HF failure gets cancer. What can't you give em for chemotheraphy Doxorubicin or daunorubicin b/c they are cardiotoxic
Chromosomal analysis of a leukemia pt reveals the presence of the philadelphia chromosome (t9;22)what is the tx? CML = imatinib
after makin a baby, a mom bleeds a lot from vagina and gums. What are the abn lab values? (DIC from amniotic fluid embolus) = increased BT, PT, PTT, decreased platelets, increased D dimer
11 yo kid with chronic non healing ulcer on foot and a calcified spleen. Drug? (SCA) hydroxyurea (makes HgF)
NSAIDs inhibit the production of which substance important in platelet aggregation? thromboxane
HbF and 2,3-bisphosphoglycerate Less affinity than HbA
aids conversion of plasminogen to plasmin. cleaves fibrin, breaks down clots. streptokinase, urokinase, tPA
acetylates and irreversibly inhibits COX1/2 to prevent conversion of arachadonic acid to TX aspirin
inibits aggregation by blocking ADP ribosylation. Inhibits fibrinogen binding by preventing expression of gp IIb/IIIa clopidigrel, ticlopidine
inhibits aggregation by binding to gpIIb/IIIA on platelets abciximab, tirofiban, eptifibatide
catalyzes antithrombin II formation and activation (low MW heparin) enoxaparin
Created by: kayjames