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DIT heme quiz
| Question | Answer |
|---|---|
| age distribution of Hodgkin's lymphoma | bimodal distribution |
| age distribution of non-Hodgkin's lymphoma | 20-40s |
| most common type of non-hodgkin's lymphoma in adults | Diffuse large B cell lymphoma |
| most common type of non-Hodgkin's lymphoma in kids | lymphoblastic lymphoma |
| lab findings in DIC | decreased platelet count, increased Bleeding Time, PT, PTT, and D-dimer |
| What is the structure of HbH | beta4 |
| what disease results in HbH production | alpha thalassemia w/ 3 deletions |
| what is the structure of Hb Barts | gamma4 |
| what disease results in Hb Barts production | alpha thalassemia w/ 4 deletions |
| + Ham's test | PNH |
| Heinz bodies | G6PD deficiency |
| basophilic stippling | (TAIL) Thalassemia, ACD, iron def, LEAD POISONING |
| + osmotic fragility test | hereditary spherocytosis |
| + DEB test | Fanconi anemia |
| D-dimers | DIC, DVT, Budd-chiari |
| + coombs | a/i hemolytic anemia |
| - coombs | nL hemolytic anemia |
| + ristocetin test | von willebrands disease |
| causes of aplastic anemia | RADIATION, drugs(benzene, chlorpromazine, alkylating agents), viruses(PVB19, EBV, HIV, HCV), fanconi's anemia, idiopathic |
| A pt has hypercalcemia from the most common primary tumor in the bones of adults. Lab findings? | (MM) M spike, bence jones protein, anemia, roleaux, punched out lytic bone lesions |
| findings a/w hereditary spheroctosis | osmotic fragility, sm RBCs with no central pallor, increased MCHC, increased RDW, splenomegaly, aplastic crisis, pigmented gallstones, jaundince, cooombs negative |
| Lab findings in iron def anemia | increased TIBC, decreased ferritin, decreased FE/TIBC |
| Lab findings in thalassemia | Fe NL, target cells |
| a child anemic since birth has now been cured with splenectomy. what did it have? | hereditary spherocytosis |
| danger of giving folate alone to a pt with macrocytic megaloblastic anemia | it'll mask B12 deficiency |
| anemia, hypercalcemia, bone pain and plasma cells (lg, round off center nucleus) in bone marrow biopsy | MM, nothing in urinalysis, M spike on UPEP |
| neoplasms a/w AIDS | kaposi sarcoma, HPV, primary CNS lymphoma, NOn-hodgkins lymphoma |
| A HF failure gets cancer. What can't you give em for chemotheraphy | Doxorubicin or daunorubicin b/c they are cardiotoxic |
| Chromosomal analysis of a leukemia pt reveals the presence of the philadelphia chromosome (t9;22)what is the tx? | CML = imatinib |
| after makin a baby, a mom bleeds a lot from vagina and gums. What are the abn lab values? | (DIC from amniotic fluid embolus) = increased BT, PT, PTT, decreased platelets, increased D dimer |
| 11 yo kid with chronic non healing ulcer on foot and a calcified spleen. Drug? | (SCA) hydroxyurea (makes HgF) |
| NSAIDs inhibit the production of which substance important in platelet aggregation? | thromboxane |
| HbF and 2,3-bisphosphoglycerate | Less affinity than HbA |
| aids conversion of plasminogen to plasmin. cleaves fibrin, breaks down clots. | streptokinase, urokinase, tPA |
| acetylates and irreversibly inhibits COX1/2 to prevent conversion of arachadonic acid to TX | aspirin |
| inibits aggregation by blocking ADP ribosylation. Inhibits fibrinogen binding by preventing expression of gp IIb/IIIa | clopidigrel, ticlopidine |
| inhibits aggregation by binding to gpIIb/IIIA on platelets | abciximab, tirofiban, eptifibatide |
| catalyzes antithrombin II formation and activation (low MW heparin) | enoxaparin |
Created by:
kayjames
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