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DIT RBC path
Question | Answer |
---|---|
basophilic stippling | lead poisoning |
heinz and bite cells | G6PD deficiency |
schistocytes | DIC |
acanthocytes (spur cells) | abetalipoproteinemia |
howell-jolly bodies | asplenia |
microcytic anemia + swallowing difficulty + glossitis | iron deficiency (plummer vinson) |
microcytic anemia + >3.5% HbA2 | beta thal minor |
megaloblastic anemia not correctable by B12 or folate | orotic aciduria |
megaloblastic anemia along with peripheral neuropathyy | B12 deficiency |
microcytic anemia + basophilic stippling | lead poisoning |
microcytic anemia reversible with B6 | sideroblastic anemia |
HIV positive pt with macrocytic anemia | AZT |
Normocytic anemia + red urine in the morning | PNH |
normocytic anemia and elevated creatinine | CKD --> decreased EPo |
nearly always IgM | cold agglutinins |
occur regularly in infx with M.pn, EBV, some malignancies | cold agglutinins |
disease occurs when there is circulation to a cold extremity. IgM binds RBC antigen --> complement cascade | cold agglutinins |
Nearly always IgG | warm agglutinins |
seen in viruses (EBV, HIV), SLE, malignancies, congenital immune abn | warm agglutinins |
rate limiting step of heme synthesis | alpha aminolevulinic acid synthase |
cause of ITP | decreased platelet survival d2 Gp IIb/IIIa abs |
what is the defect in bernard-soulier disease | GpIb (platelet to collagen adhesion) |
what is the most common inherited bleeding disorder? | VWD |
whate are some of the hereditary syndromes of thrombosis? | Factor V Leiden, Prothrombin gene mutation, ATIII def, protein C/S def |
Hams test | PNH |
DEB test | Fanconi's anemia |
Heinz bodies | G6PD def |
D dimers | DIC |
basophilic stippling | lead poisoning, thalassemia, iron def, ACD |
osmotic fragility test | hereditary spherocytosis |
+ ristocetin test | VWD |