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DIT Heme A&P

QuestionAnswer
what allows RBCs to change shape as they pass through vessels? spectrin
What are some of the different causes of polycythemia? (excess EPo) RCC, HCC, pheoCC, hemangioblastoma, Down's, Polycythemia Vera, Hypoxia (COPD, OSA, high alt)
What coag factor is deficient in hemophilia A VIII
what coag factor is deficient in hemophilia B IX
what clotting factors require vit K for synthesis 10, 9, 7, 2, protein C, protein S
Tx for heparin overdose protamine sulfate
Tx for warfarin overdose Vit K and FFP
lab value used to monitor heparin PTT
lab value used to monitor warfarmin PT/INR
lab value used to monitor enoxaparin Factor Xa activity
Tx for heparin induced thrombocytopenia? Stop heparin. Lepirudin, Bivalirudin
cofactor for the activation of antithrombin. decreases thrombin and Xa heparin
interferes with gamma carboxlation of vit K dependent lotting factors Warfarin
Has effect on extrinsic pathway and increases PT warfarin
accelerating factors V, VIII
inhibit accelerating factors protein C and S
clot buster plasmin
converts fibrinogen to fibrin thrombin
converts prothrombin to thrombin Va
converts Plasminogen to plasmin kallikrein
activates extrinsic coagulation pathway thromboplastin converts VII-->VIIa
activates intrinsic coagulation pathway collagen, basement membrane and activated platelets convert XII--> XIIa
inhibits thrombin and factors IXa, Xa, XIa, and XIIa antithrombin
proaggregation TXA2
antiaggregation PGI2 and NO
inhibits COX (TXA2 synthesis) aspirin
inhibits ADP induced expression of GpIIb/IIIa Ticlopidine and clopigrel
inhibits GpIIb/IIIa directl abciximab
Created by: kayjames