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DIT immunosuppressan

precursor of 6-mercaptopurine azathioprine
may prevent nephrotoxicity with mannitol diuresis cyclosporine
ab that binds to CD3 on T cells muromonab CD3
ab that binds IL-2 receptor on activated T cells daclizumab
inhibits inosine monophosphate dehydrogenase mycophenylate
inhibits calcineurin = loss of IL-2 production = blockage of T cell differentiation and activation cyclosporin
binds FK-binding proteins = loss of IL-2 production tacrolimus
bind FKBP-12 = inhibition of mTOR = inhibition of T cell proliferation sirolimus
used for lupus nephritis mycophenylate
metabolized by xanthine oxidase, therefore allopurinol increases its toxicity azathioprine
Created by: kayjames



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