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DIT musculoskeletal
| Question | Answer |
|---|---|
| zona occludens | tight junction |
| prevents diffusion across paracellular space | zona occludens |
| compsed of claudins and occludins | zona occludens |
| zona adherens | intermediate junction |
| just below zona occludens | zona adherens |
| cadhereins connect to actin | zona adherens |
| calcium dependent adhesion molecules | cadherins |
| macula adherens | desmosome |
| small discrete sties of attachment | macula adherens |
| cadherins connect to intermediate filaments | macula adherens |
| pemphigus vulgaris | macula adherens/desmosome |
| allows adjacent cells to communicate for electric and metabolic functions | gap junctions |
| keratin | mactula adherens |
| connects cells to underlying extracellular matrix | hemidesmosome |
| bullous pemphigoid | hemidesmosome |
| integrins | hemidesmosome |
| maintains integrity of basement membrane | integrin |
| binds to laminin in basement membrane | integrin |
| where does new bone formation take place in growing long bones? | epiphyseal plate |
| football player kicked in the leg ahs a damaged medial meniscus. What else is likely messed up? | ACL and MCL = unhappy triad |
| initial 15 degrees of arm abduction | supraspinatous |
| lateral rotation of arm | infraspinatus/teres minor |
| medial rotation of arm | subscapularis |
| head of humerus rotates out of glenoid cavity | dislocated shoulder |
| clavicle separates from acromion and coaracoid process of the scapula | separated shoulder |
| damaged in anterior shoulder dislocation | axillary n, post circumflex a, supraspinatous tendon |
| contains only thick fibers | H band |
| contains only thin fibers | I band |
| actin | thin |
| myosin | thick |
| never changes | A band |
| smaller during contraction | I band |
| Reversible when vit d is replaced | osteomalacia/rickets |
| excess osteoclastic activity results in disorganized bony architecture | pagets |
| bone is replaced by fibroblasts, collagen, and irregular bony trabeculae | polyosteitis fibrous dysplasi |
| soft bones due to defective mineralization of osteoid | osteomalacia/rickets |
| failure of bone resorption causing thickened and dense bones | osteopetrosis |
| genetic deficiency of carbonic anhydrase II | osteopetrosis |
| Alk Phos is very elevated, everything else is normal | pagets disease |
| most common malignant primary bone tumor of children | osteosarcoma |
| most common malignant primary bone tumor in adults | multiple myeloma |
| most common benign bone tumor | osteochondroma |
| 11;22 translocation | Ewing's sarcoma |
| soap-bubble appearnace on x ray | giant cell tumor (osteoclastoma |
| Onion skin appearance of bone | Ewings |
| May actually be a hamartoma | osteochondroma |
| codman's triange on x ray | osteosarcoma |
| associated with gardner's syndrome | osteoma |
| knee pain and swelling, subcutaneous nodules around joins and achilles tendon, pain in the MTP joint of big toes. needle like crystals on biopsy | Gout |
| treatment of acute gout exacerbation | NSAID, colchicine, steroids |
| difficulty swallowing, distal cyanosis in cold temperatures, and anti-centromere antibodes. What else would you see in this pt? | (CREST scleroderma) + calcinosis, sclerodactyly, telangiectasias |
| photosensitivity, arthritis, renal disease, recurrent oral ulcers on primaquine and NSAIDS. What type of check up should she get twice a year? | Lupus. check for nephropathy. Proteinuria, creatinine, dsDNA |
| Blood test to confirm Lupus | anti dsDNA antibodies. ANA as a screen |
| bilateral hilar lympadenopathy | sarcoidosis |
| acute knee pain and swelling. absesnse of erosion. calcium in the menisci. | Pseudogout = calcium pyrophosphate crystals |
| Hyperkeratosis, sebum overproduction, propionibacterium proliferation, inflammation | acne |
| pruritic, purple, polygonal papules | lichen planus |
| life threatening rash with bulla | pemphigus vulgaris/ steven johnson/ TEN |
| pruritis a/w asthma | atopic dermatitis (eczema) |
| pruritic vesicles a/w celiac disease | dermatitis herpeteformis |
| allergy to nickel | allergic contact dermatitis (type 4 HS) |
| thickened scar, esp. around face/chest | keloid |
| abs against epidermal basement membrane | bullous pemphigoid |
| abs against epidermal cell surface | pemphigus vulgaris |
| parakeratotic scaling | psoriasis |
| keratin-filled cysts | sebhorric keratosis |
| sand-paper; predisposition to squamous cell cancer | actinic keratosis |
| skin rash and proximal muscle weakness | dermatomyositis |
| honey-crusting lesions common about the nose an d lips | impetigo |
| hyperkeratosis and koilocytosis | verrucae with HPV |
| histology shows palisading nuclei | basal cell carcinoma |
Created by:
kayjames
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