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DIT DM drugs

oral agents to control type 2 diabetes

QuestionAnswer
lactic acidosis is a rare but worrisome side effect Metformin
most common side effect is hypoglycemia sulfonylureas
often used in combo with any other oral agent Metformin
also helps lower triglycerides and LDL cholesterol Metformin
not safe in settings of hepatic dysfunction or CHF metformin/glitazones
should not be used in pts with elevated serum creatinine Metformin
should not be used in pts with liver cirrhosis, elevated serum creatinine or IBD alpha glucosidase inhibitors
Hepatic serum transaminase levels should be carefully monitored when using these agents metformin/glitazones
not associated with weigt gain, often used in overweight diabetics Metformin
metabolized by liver; excellent choice in pts with renal disease glitazones
primarily effects postprandial hyperglycemia alpha glucosidase inhibitors
MOA: closes K channel on beta cells --> depolarization --> Ca influx --> insulin release sulfonylureas
MOA: inhibits alpha-glucosidase at intestinal brush border alpha glucosidase inhibitors
MOA: agonist at PPARgamma receptors --> improved target cell response to insulin TZDs
28 yo with well managed IDDM comes in with DKA. Recently had a cold and took OTC meds. Why does he have DKA? infections can cause DKA
How is hemoglobin glycosylated in DM to form HbA1c non enzymatic glycosylation
Created by: kayjames