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DIT mycobac agents

QuestionAnswer
what drug cocktail is used to treat tb? Rifampin, Isoniazid, Pyrazinamide, ethambutol
What is the only agent used as solo prophylaxis in TB? INH
What antibiotic is used for prevention of MAI in AIDS pts? When should this begin? Azithromycin, when CD4<50
What is an important side effect of ethambutol? (eye) Optic neuropathy, Re/Gr color blindness, decreased visual acuity
What is the mecahnism of isoniazid? Decreased synthesis of mycolic acid
What are the side effects of isonizid? Neurotoxicity, Nephrotoxicity, Lupus.
What drugss cause drug induced lupus? (SHIPP) Sulfonamides, Hydralazine, INH, Procainamide, Phenytoin
For which infections is rifampin used? TB, Leprosy. Meningococcal prophylaxis. Chemoprophylaxis in kids for H. flu
What are the R's of Rifampin RNA pol inhibitor, Revs up P450, Red-Orange secretions Rapid resistance if used alone
What drugs induce cyt p450 (BCG PQRS) Barbituates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St John's wort
Which drugs inhibit cyt p450 (PICK EGS) Protease Inhibitors, INH, Cimetidine, Ketoconazole, Erythromycin, GF juice, Sulfonamides
Gonorrhea tx ceftriaxone
syphillis tx Benzathine Pen G.
Recurrent UTIs TMP-SMX
P jiroveci pneumonia TMP-SMX
exposure to meningococcal or H flu type B meningitis Rifampin
Endocarditis prevention in pt with turbulent flow heart disease Penicillin
Created by: kayjames