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DIT cancer drugs

QuestionAnswer
forms a complex between topoisomerase II and DNA etoposide
alkylates DNA, toxicity = pulmonary fibrosis Busulfan
fragments DNA, toxicity = pulmonary fibrosis Bleomycin
blocks purine synthesis, metabolized by xanthine oxidase 6 mercaptopurine
cross-links DNA, nephrotoxic, ototoxic cisplatin, carboplatin
nitrogen mustard, alkylates DNA (electrophil which binds DNA) cyclophosphamide
Prevents tubulin assembly vincristine/vinblastine
prevents tubulin disassembly paclitaxel/ taxols
folic acid analog that inhibits dihydrofolate reductase methotrexate
intercalates DNA, produces oxygen free radicals, cardiotoxic doxorubicin
DNA alkylating agents used in brain cancer nitrosoureas
inhibits thymidylate synthase = decreased nucleotide synthesis 5FU
SERM - blocks estrogen binds to ER+ cells tamoxifen, raloxifene
Mechanism similar to antivirals acyclovir and foscarnet Cyterabine
mechanism similar to fluoroquinolones etoposide
mechanism similar to trimethoprim methotrexate
monoclonal ab against HER-2 (erb-B2) trastuzumab
free radical induced DNA strand breakage Doxorubicin, bleomycin
Ihibitor of PRPP synthetase 6 mercaptopurine
reversible with leucovorin methotrexate
treatment for choriocarcinoma methotrexate, vincristine
treatment for AML cyterabine
treatment for CML busulfan, imatinib
prevents breast cancer tamoxifene
treatment for testicular cancer bleomycin, etoposide, cisplatin
applied topically for AKs and Basal cell cancers 5FU
Treatment for childhood tumors (ewings, wilms, rhabdomyosarcoma) dactinomycin
inhibits ribonucleotide reductase hydroxyurea
SE of hemorrhagic cystitis cyclophosphamide
antibody against philadelphia chromosome busulfan
side effects of prednisone cushing-like syndrome, immunosuppression, psychosis, acne, cataracts, osteoporosis, HTN, hyperglycemia, peptic ulcers, insomnia
Created by: kayjames
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